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Volumn 75, Issue 8, 2007, Pages 3868-3876

Clostridium difficile toxins A and B directly stimulate human mast cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANTIBIOTIC AGENT; BETA N ACETYLHEXOSAMINIDASE; BIOLOGICAL MARKER; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; CYTOKINE; INTERLEUKIN 8; LATRUNCULIN B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN D2; PROSTAGLANDIN E2; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 34547626991     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00195-07     Document Type: Article
Times cited : (49)

References (48)
  • 1
    • 0030930693 scopus 로고    scopus 로고
    • Mast cells in infection and immunity
    • Abraham, S. N., and R. Malaviya. 1997. Mast cells in infection and immunity. Infect. Immun. 65:3501-3508.
    • (1997) Infect. Immun , vol.65 , pp. 3501-3508
    • Abraham, S.N.1    Malaviya, R.2
  • 3
    • 0037129306 scopus 로고    scopus 로고
    • Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway
    • Arai, A., E. Kanda, and O. Miura. 2002. Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway. Oncogene 21:2641-2651.
    • (2002) Oncogene , vol.21 , pp. 2641-2651
    • Arai, A.1    Kanda, E.2    Miura, O.3
  • 5
    • 0023950976 scopus 로고
    • Establishment of an immature mast cell line from a patient with mast cell leukemia
    • Butterfield, J. H., D. Weiler, G. Dewald, and G. J. Gleich. 1988. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 12:345-355.
    • (1988) Leuk. Res , vol.12 , pp. 345-355
    • Butterfield, J.H.1    Weiler, D.2    Dewald, G.3    Gleich, G.J.4
  • 8
    • 0035253356 scopus 로고    scopus 로고
    • Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells
    • Djouder, N., G. Schmidt, M. Frings, A. Cavalié, M. Thelen, and K. Aktories. 2001. Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. J. Immunol. 166:1627-1634.
    • (2001) J. Immunol , vol.166 , pp. 1627-1634
    • Djouder, N.1    Schmidt, G.2    Frings, M.3    Cavalié, A.4    Thelen, M.5    Aktories, K.6
  • 9
    • 0034705437 scopus 로고    scopus 로고
    • Inhibition of calcium release-activated calcium current by Rac/Cdc42- inactivating clostridial cytotoxins in RBL cells
    • Djouder, N., U. Prepens, K. Aktories, and A. Cavalié. 2000. Inhibition of calcium release-activated calcium current by Rac/Cdc42- inactivating clostridial cytotoxins in RBL cells. J. Biol. Chem. 275:18732-18738.
    • (2000) J. Biol. Chem , vol.275 , pp. 18732-18738
    • Djouder, N.1    Prepens, U.2    Aktories, K.3    Cavalié, A.4
  • 10
    • 0038466330 scopus 로고    scopus 로고
    • Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome
    • Dobson, G., C. Hickey, and J. Trinder. 2003. Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome. Intensive Care Med. 29:1030.
    • (2003) Intensive Care Med , vol.29 , pp. 1030
    • Dobson, G.1    Hickey, C.2    Trinder, J.3
  • 11
    • 0041659182 scopus 로고    scopus 로고
    • Actin remodeling to facilitate membrane fusion
    • Eitzen, G. 2003. Actin remodeling to facilitate membrane fusion. Biochim. Biophys. Acta 1641:175-181.
    • (2003) Biochim. Biophys. Acta , vol.1641 , pp. 175-181
    • Eitzen, G.1
  • 12
    • 0033558012 scopus 로고    scopus 로고
    • The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells
    • Frigeri, L., and J. R. Apgar. 1999. The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells. J. Immunol. 162:2243-2250.
    • (1999) J. Immunol , vol.162 , pp. 2243-2250
    • Frigeri, L.1    Apgar, J.R.2
  • 13
    • 0033000657 scopus 로고    scopus 로고
    • Mast cells as sentinels of innate immunity
    • Galli, S. J., M. Maurer, and C. S. Lantz. 1999. Mast cells as sentinels of innate immunity. Curr. Opin. Immunol. 11:53-59.
    • (1999) Curr. Opin. Immunol , vol.11 , pp. 53-59
    • Galli, S.J.1    Maurer, M.2    Lantz, C.S.3
  • 14
    • 0034042599 scopus 로고    scopus 로고
    • The F-actin cytoskeleton modulates slow secretory components rather than readily releasable vesicle pools in bovine chromaffin cells
    • Gil, A., J. Rueda, S. Viniegra, and L. M. Gutierrez. 2000. The F-actin cytoskeleton modulates slow secretory components rather than readily releasable vesicle pools in bovine chromaffin cells. Neuroscience 98:605-614.
    • (2000) Neuroscience , vol.98 , pp. 605-614
    • Gil, A.1    Rueda, J.2    Viniegra, S.3    Gutierrez, L.M.4
  • 15
    • 0036207579 scopus 로고    scopus 로고
    • Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation
    • He, D., S. Sougioultzis, S. Hagen, J. Liu, S. Keates, A. C. Keates, C. Pothoulakis, and J. T. LaMont. 2002. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology 122:1048-1057.
    • (2002) Gastroenterology , vol.122 , pp. 1048-1057
    • He, D.1    Sougioultzis, S.2    Hagen, S.3    Liu, J.4    Keates, S.5    Keates, A.C.6    Pothoulakis, C.7    LaMont, J.T.8
  • 17
    • 0035970065 scopus 로고    scopus 로고
    • Activated Cdc42/Rac reconstitutes Fcepsilon Rl-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells
    • Hong-Geller, E., D. Holowka, R. P. Siraganian, B. Baird, and R. A. Cerione. 2001. Activated Cdc42/Rac reconstitutes Fcepsilon Rl-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells. Proc. Natl. Acad. Sci. USA 98:1154-1159.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1154-1159
    • Hong-Geller, E.1    Holowka, D.2    Siraganian, R.P.3    Baird, B.4    Cerione, R.A.5
  • 18
    • 1342345853 scopus 로고    scopus 로고
    • Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis
    • Ishida, Y., T. Maegawa, T. Kondo, A. Kimura, Y. Iwakura, S. Nakamura, and N. Mukaida. 2004. Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis. J. Immunol. 172:3018-3025.
    • (2004) J. Immunol , vol.172 , pp. 3018-3025
    • Ishida, Y.1    Maegawa, T.2    Kondo, T.3    Kimura, A.4    Iwakura, Y.5    Nakamura, S.6    Mukaida, N.7
  • 19
    • 0028177598 scopus 로고    scopus 로고
    • Just, I., G. Fritz, K. Aktories, M. Giry, M. R. Popoff, P. Boquet, S. Hegenbarth, and C. Von Eichel-Streiber. 1994. Clostridium difficile toxin B acts on the GTP-binding protein Rho. J. Biol. Chem. 269:10706- 10712.
    • Just, I., G. Fritz, K. Aktories, M. Giry, M. R. Popoff, P. Boquet, S. Hegenbarth, and C. Von Eichel-Streiber. 1994. Clostridium difficile toxin B acts on the GTP-binding protein Rho. J. Biol. Chem. 269:10706- 10712.
  • 23
    • 20444395071 scopus 로고    scopus 로고
    • Clostridium difficile toxin A regulates inducible COX-2 and PGE2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAP kinase
    • Kim, H., S. H. Rhee, E. Kokkotou, X. Na, T. Savidge, M. P. Moyer, C. Pothoulakis, and J. T. LaMont. 2005. Clostridium difficile toxin A regulates inducible COX-2 and PGE2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAP kinase. J. Biol. Chem. 280:21237-21245.
    • (2005) J. Biol. Chem , vol.280 , pp. 21237-21245
    • Kim, H.1    Rhee, S.H.2    Kokkotou, E.3    Na, X.4    Savidge, T.5    Moyer, M.P.6    Pothoulakis, C.7    LaMont, J.T.8
  • 24
    • 0035992642 scopus 로고    scopus 로고
    • Differential expression and polarized secretion of CXC and CC chemokines by human intestinal epithelial cancer cell lines in response to Clostridium difficile toxin A
    • Kim, J. M., J. S. Kim, H. C. Jun, Y. K. Oh, I. S. Song, and C. Y. Kim. 2002. Differential expression and polarized secretion of CXC and CC chemokines by human intestinal epithelial cancer cell lines in response to Clostridium difficile toxin A. Microbiol. Immunol. 46:333-342.
    • (2002) Microbiol. Immunol , vol.46 , pp. 333-342
    • Kim, J.M.1    Kim, J.S.2    Jun, H.C.3    Oh, Y.K.4    Song, I.S.5    Kim, C.Y.6
  • 25
    • 33745536745 scopus 로고    scopus 로고
    • NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
    • Kim, J. M., J. Y. Lee, Y. M. Yoon, Y. K. Oh, J. Youn, and Y. J. Kim. 2006. NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A. Scand. J. Immunol. 63:453-460.
    • (2006) Scand. J. Immunol , vol.63 , pp. 453-460
    • Kim, J.M.1    Lee, J.Y.2    Yoon, Y.M.3    Oh, Y.K.4    Youn, J.5    Kim, Y.J.6
  • 26
    • 0023388361 scopus 로고
    • Purification of Clostridium difficile toxin A by affinity chromatography on immobilized thyroglobulin
    • Krivan, H. C., and T. D. Wilkins. 1987. Purification of Clostridium difficile toxin A by affinity chromatography on immobilized thyroglobulin. Infect. Immun. 55:1873-1877.
    • (1987) Infect. Immun , vol.55 , pp. 1873-1877
    • Krivan, H.C.1    Wilkins, T.D.2
  • 27
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis, J. M., and J. Avruch. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:807-869.
    • (2001) Physiol. Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 28
    • 0032476593 scopus 로고    scopus 로고
    • Fc receptor-mediated phagocytosis requires Cdc42 and Rac1
    • Massol, P., P. Montcourrier, J.-C. Guillemot, and P. Chavrier. 1998. Fc receptor-mediated phagocytosis requires Cdc42 and Rac1. EMBO J. 17: 6219-6229.
    • (1998) EMBO J , vol.17 , pp. 6219-6229
    • Massol, P.1    Montcourrier, P.2    Guillemot, J.-C.3    Chavrier, P.4
  • 30
    • 0344406175 scopus 로고    scopus 로고
    • Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells
    • Neco, P., O. Rosetto, A. Gil, C. Montecucco, and L. M. Gutierrez. 2003. Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells. J. Neurochem. 85:329-337.
    • (2003) J. Neurochem , vol.85 , pp. 329-337
    • Neco, P.1    Rosetto, O.2    Gil, A.3    Montecucco, C.4    Gutierrez, L.M.5
  • 31
    • 2642515740 scopus 로고    scopus 로고
    • Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells
    • Németh, Z. H., E. A. Deitch, M. T. Davidson, C. Szabo, E. S. Vizi, and G. Hasko. 2004. Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells. J. Cell Physiol. 200:71-81.
    • (2004) J. Cell Physiol , vol.200 , pp. 71-81
    • Németh, Z.H.1    Deitch, E.A.2    Davidson, M.T.3    Szabo, C.4    Vizi, E.S.5    Hasko, G.6
  • 33
    • 0037515668 scopus 로고    scopus 로고
    • Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells
    • Pendleton, A., B. Pope, A. Weeds, and A. Koffer. 2003. Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells. J. Biol. Chem. 278:14394-14400.
    • (2003) J. Biol. Chem , vol.278 , pp. 14394-14400
    • Pendleton, A.1    Pope, B.2    Weeds, A.3    Koffer, A.4
  • 34
    • 4444382260 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: A changing pattern of disease severity
    • Pépin, J., L. Valiquette, M. E. Alary, P. Villemure, A. Pelletier, K. Forget, K. Pepin, and D. Chouinard. 2004. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 171:466-472.
    • (2004) CMAJ , vol.171 , pp. 466-472
    • Pépin, J.1    Valiquette, L.2    Alary, M.E.3    Villemure, P.4    Pelletier, A.5    Forget, K.6    Pepin, K.7    Chouinard, D.8
  • 35
    • 2942672691 scopus 로고    scopus 로고
    • Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells
    • Petry, C., G. Fritz, J. Pfeilschifter, and A. Huwiler. 2004. Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells. Biochim. Biophys. Acta 1638:108-118.
    • (2004) Biochim. Biophys. Acta , vol.1638 , pp. 108-118
    • Petry, C.1    Fritz, G.2    Pfeilschifter, J.3    Huwiler, A.4
  • 36
    • 0032390474 scopus 로고    scopus 로고
    • Nerves and intestinal mast cells modulate responses to enterotoxins
    • Pothoulakis, C., I. Castagliuolo, and J. T. LaMont. 1998. Nerves and intestinal mast cells modulate responses to enterotoxins. News Physiol. Sci. 13: 58-63.
    • (1998) News Physiol. Sci , vol.13 , pp. 58-63
    • Pothoulakis, C.1    Castagliuolo, I.2    LaMont, J.T.3
  • 37
    • 0029665076 scopus 로고    scopus 로고
    • Inhibition of Fc εRI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)
    • Prepens, U., I. Just, C. Von Eichel-Streiber, and K. Aktories. 1996. Inhibition of Fc εRI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase). J. Biol. Chem. 271:7324-7329.
    • (1996) J. Biol. Chem , vol.271 , pp. 7324-7329
    • Prepens, U.1    Just, I.2    Von Eichel-Streiber, C.3    Aktories, K.4
  • 38
    • 0030987740 scopus 로고    scopus 로고
    • Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: Role of interleukin-1β, tumor necrosis factor alpha, and leukotrienes
    • Rocha, M. F. G., M. E. T. Maia, L. R. P. S. Bezerra, D. M. Lyerly, R. L. Guerrant, R. A. Ribeiro, and A. A. M. Lima. 1997. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1β, tumor necrosis factor alpha, and leukotrienes. Infect. Immun. 65:2740-2746.
    • (1997) Infect. Immun , vol.65 , pp. 2740-2746
    • Rocha, M.F.G.1    Maia, M.E.T.2    Bezerra, L.R.P.S.3    Lyerly, D.M.4    Guerrant, R.L.5    Ribeiro, R.A.6    Lima, A.A.M.7
  • 39
    • 0019416681 scopus 로고
    • Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells
    • Schwartz, L. B., C. Riedel, J. P. Caulfield, S. I. Wasserman, and K. F. Austen. 1981. Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells. J. Immunol. 1226: 2071-2078.
    • (1981) J. Immunol , vol.1226 , pp. 2071-2078
    • Schwartz, L.B.1    Riedel, C.2    Caulfield, J.P.3    Wasserman, S.I.4    Austen, K.F.5
  • 40
    • 28044441113 scopus 로고    scopus 로고
    • Human mucosa/submucosa interactions during intestinal inflammation: Involvement of the enteric nervous system in interleukin-8 secretion
    • Tixier, E., F. Lalanne, I. Just, J. P. Galmiche, and M. Neunlist. 2005. Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin-8 secretion. Cell. Microbiol. 7:1798-1810.
    • (2005) Cell. Microbiol , vol.7 , pp. 1798-1810
    • Tixier, E.1    Lalanne, F.2    Just, I.3    Galmiche, J.P.4    Neunlist, M.5
  • 41
    • 3242694466 scopus 로고    scopus 로고
    • Involvement of filamentous actin in setting the threshold for degranulation in mast cells
    • Tolarova, H., L. Draberova, P. Heneberg, and P. Draber. 2004. Involvement of filamentous actin in setting the threshold for degranulation in mast cells. Eur. J. Immunol. 34:1627-1636.
    • (2004) Eur. J. Immunol , vol.34 , pp. 1627-1636
    • Tolarova, H.1    Draberova, L.2    Heneberg, P.3    Draber, P.4
  • 42
    • 0031714791 scopus 로고    scopus 로고
    • Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans
    • Tsikas, D. 1998. Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans. J. Chromatogr. 717:201-245.
    • (1998) J. Chromatogr , vol.717 , pp. 201-245
    • Tsikas, D.1
  • 43
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322.
    • (1997) Genes Dev , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 44
    • 0031967123 scopus 로고    scopus 로고
    • Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice
    • Wershil, B. K., I. Castagliuolo, and C. Pothoulakis. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114:956-964.
    • (1998) Gastroenterology , vol.114 , pp. 956-964
    • Wershil, B.K.1    Castagliuolo, I.2    Pothoulakis, C.3
  • 45
    • 0030938299 scopus 로고    scopus 로고
    • Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells
    • Wex, C. B. A., G. Koch, and K. Aktories. 1997. Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 355:328-334.
    • (1997) Naunyn-Schmiedeberg's Arch. Pharmacol , vol.355 , pp. 328-334
    • Wex, C.B.A.1    Koch, G.2    Aktories, K.3
  • 46
    • 0043193467 scopus 로고    scopus 로고
    • Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts
    • Woo, C. H., and J. H. Kim. 2002. Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Mol. Cells 13:470-475.
    • (2002) Mol. Cells , vol.13 , pp. 470-475
    • Woo, C.H.1    Kim, J.H.2
  • 47
    • 4644305046 scopus 로고    scopus 로고
    • Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-κB pathway
    • Wu, S., J. Powell, N. Mathioudakis, S. Kane, E. Fernandez, and C. L. Sears. 2004. Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-κB pathway. Infect. Immun. 72: 5832-5839.
    • (2004) Infect. Immun , vol.72 , pp. 5832-5839
    • Wu, S.1    Powell, J.2    Mathioudakis, N.3    Kane, S.4    Fernandez, E.5    Sears, C.L.6
  • 48
    • 0141996311 scopus 로고    scopus 로고
    • Rho GTPases as therapeutic targets for the treatment of inflammatory dieseases
    • Zhao, D., and C. Pothoulakis. 2003. Rho GTPases as therapeutic targets for the treatment of inflammatory dieseases. Expert Opin. Ther. Targets 7:583-592.
    • (2003) Expert Opin. Ther. Targets , vol.7 , pp. 583-592
    • Zhao, D.1    Pothoulakis, C.2


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