IL-10 production in macrophages is regulated by a TLR-driven CREB-mediated mechanism that is linked to genes involved in cell metabolism

Journal of Immunology

Volumn 195, Issue 3, 2015, Pages 1218-1232

  Sanin, David E ^a,b   Prendergast, Catriona T ^a,c   Mountford, Adrian P ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EARLY ENDOSOME ANTIGEN 1; INTERLEUKIN 10; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN P105; S6 KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; CREB1 PROTEIN, MOUSE; DNA BINDING PROTEIN; IL10 PROTEIN, MOUSE; IL12A PROTEIN, MOUSE; INTERLEUKIN 12P35; MAP3K8 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MYD88 PROTEIN, MOUSE; ONCOPROTEIN; RELA PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOINFORMATICS; BONE MARROW DERIVED MACROPHAGE; CELL METABOLISM; CELL STIMULATION; CERCARIA; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GLYCOLYSIS; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE; MICROENVIRONMENT; MOLECULAR DYNAMICS; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SKIN RESIDENT TISSUE MACROPHAGE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; ENERGY METABOLISM; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PARASITOLOGY; PHOSPHORYLATION;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; ENERGY METABOLISM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERLEUKIN-10; INTERLEUKIN-12 SUBUNIT P35; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

EID: 84937697237     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500146     Document Type: Article

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