Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 3383-3392

  Donnelly, Sheila ^a,b   O'Neill, Sandra M ^c   Stack, Colin M ^a,d   Robinson, Mark W ^a   Turnbull, Lynne ^a   Whitchurch, Cynthia ^a   Dalton, John P ^a,e  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c DUBLIN CITY UNIVERSITY   (Ireland)

^d UNIVERSITY OF WESTERN SYDNEY   (Australia)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; CELL MEMBRANES; MACROPHAGES; MAMMALS; MOLECULES; NITRIC OXIDE; SAMARIUM COMPOUNDS;

HELMINTH PARASITES; INFLAMMATORY MEDIATORS; INNATE IMMUNE RESPONSE; LIPOPOLYSACCHARIDES; SCHISTOSOMA MANSONI; SIGNALING PATHWAYS; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

BORON COMPOUNDS;

CYSTEINE PROTEINASE; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR DOMAIN CONTAINING ADAPTER INDUCING INTERFERON BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; ENDOTOXIN; MYD88 PROTEIN, MOUSE; NITRITE; RECOMBINANT PROTEIN; TICAM 1 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; TLR3 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOSOME; FASCIOLA HEPATICA; HELMINTH; INNATE IMMUNITY; LETHALITY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCHISTOSOMA MANSONI; SIGNAL TRANSDUCTION; TH1 CELL; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; ENZYMOLOGY; FEMALE; METABOLISM; MOUSE;

FASCIOLA HEPATICA; MUS; SCHISTOSOMA MANSONI; VERMES;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CYSTEINE PROTEASES; CYTOKINES; ENDOTOXINS; FEMALE; HELMINTHS; MACROPHAGES; MICE; MICE, INBRED BALB C; MYELOID DIFFERENTIATION FACTOR 88; NITRITES; RECOMBINANT PROTEINS; TH1 CELLS; TOLL-LIKE RECEPTOR 3;

EID: 77449122333     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.060368     Document Type: Article

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