Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products

Parasite Immunology

Volumn 35, Issue 5-6, 2013, Pages 147-156

  Turner, J D ^a   Meurs, L ^b   Dool, P ^a   Bourke, C D ^a   Mbow, M ^c   Dieye T N ^c   Mboup, S ^c   Polman, K ^b   Mountford, A P ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c Immunology Unit of the Laboratory of Bacteriology and Virology of Aristide Le Dantec Univ Hospital   (Senegal)

Author keywords

Cercariae; Excretory seretory antigens; Human disease; IL 10 cytokine; Schistosomiasis

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 8; MEBENDAZOLE; PRAZIQUANTEL; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BLOOD CULTURE; CERCARIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; INNATE IMMUNITY; MALE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHISTOSOMA; SCHISTOSOMA HEMATOBIUM; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHOOL CHILD;

ADOLESCENT; ADULT; ANIMALS; ANTIGENS, HELMINTH; CERCARIA; CHILD; COINFECTION; CYTOKINES; EOSINOPHILS; FEMALE; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-10; INTERLEUKIN-8; LEUKOCYTE COUNT; MALE; MIDDLE AGED; SCHISTOSOMA HAEMATOBIUM; SCHISTOSOMA MANSONI; SCHISTOSOMATIDAE; SCHISTOSOMIASIS HAEMATOBIA; SCHISTOSOMIASIS MANSONI; SENEGAL; SKIN; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84877131917     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12028     Document Type: Article

References (37)

1. Steinmann P, Keiser J, Bos R, Tanner M & Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis 2006; 6: 411-425.
2. Chitsulo L, Loverde P & Engels D. Schistosomiasis. Nat Rev Microbiol 2004; 2: 12-13.
3. Gryseels B, Polman K, Clerinx J & Kestens L. Human schistosomiasis. Lancet 2006; 368: 1106-1118.
4. Paveley RA, Aynsley SA, Cook PC, Turner JD & Mountford AP. Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells. PLoS Negl Trop Dis 2009; 3: e528.
5. Jenkins SJ, Hewitson JP, Jenkins GR & Mountford AP. Modulation of the host's immune response by schistosome larvae. Parasite Immunol 2005; 27: 385-393.
6. Curwen RS, Ashton PD, Sundaralingam S & Wilson RA. Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Mol Cell Proteomics 2006; 5: 835-844.
7. Jang-Lee J, Curwen RS, Ashton PD, et al. Glycomics analysis of Schistosoma mansoni egg and cercarial secretions. Mol Cell Proteomics 2007; 6: 1485-1499.
8. Jenkins SJ, Hewitson JP, Ferret-Bernard S & Mountford AP. Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways. Int Immunol 2005; 17: 1409-1418.
9. Paveley RA, Aynsley SA, Turner JD, et al. The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNgamma production. Int J Parasitol 2011; 41: 1335-1345.
10. Cook PC, Aynsley SA, Turner JD, et al. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog 2011; 7: e1001323.
11. Todd CW, Goodgame RW & Colley DG. Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent/phagocytic cells. J Immunol 1979; 122: 1440-1446.
12. Colley DG, Garcia AA, Lambertucci JR, et al. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. The Am Journal Trop Med Hyg 1986; 35: 793-802.
13. Contigli C, Silva-Teixeira DN, Del Prete G, et al. Phenotype and cytokine profile of Schistosoma mansoni specific T cell lines and clones derived from schistosomiasis patients with distinct clinical forms. Clin Immunol 1999; 91: 338-344.
14. Gazzinelli G, Katz N, Rocha RS & Colley DG. Immune responses during human Schistosomiasis mansoni. VIII. Differential in vitro cellular responsiveness to adult worm and schistosomular tegumental preparations. The Am Journal Trop Med Hyg 1983; 32: 326-333.
15. Bourke CD, Nausch N, Rujeni N, et al. Integrated analysis of innate, Th1, Th2, Th17 and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. J of Infect Dis 2012; doi: 10.1093/infdis/jis524.
16. Meurs L, Labuda L, Amoah AS, et al. Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon. PLoS ONE 2011; 6: e24393.
17. WHO. Preventive chemotherapy in human helminthiasis - coordinated use of anthelminthic drugs in control interventions). 2006.
18. Talla I, Kongs A, Verle P, Belot J, Sarr S & Coll AM. Outbreak of intestinal schistosomiasis in the Senegal River Basin. Ann Soc Belg Med Trop 1990; 70: 173-180.
19. Talla I, Kongs A & Verle P. Preliminary study of the prevalence of human schistosomiasis in Richard-Toll (the Senegal river basin). Trans R Soc Trop Med Hyg 1992; 86: 182.
20. Picquet M, Ernould JC & Vercruysse J, Society Royal of Tropical Medicine and Hygiene meeting at Manson House, London, 18, et al. The epidemiology of human schistosomiasis in the Senegal river basin. Trans R Soc Trop Med Hyg May 1995; 1996(90): 340-346.
21. Verle P, Stelma F, Desreumaux P, et al. Preliminary study of urinary schistosomiasis in a village in the delta of the Senegal river basin, Senegal. Trans R Soc Trop Med Hyg 1994; 88: 401-405.
22. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S & Polman K. Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal. Int J Parasitol 2012; 42: 305-311.
23. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S & Polman K. Bladder Morbidity and Hepatic Fibrosis in Mixed Schistosoma haematobium and S. mansoni Infections: A Population-Wide Study in Northern Senegal. PLoS Neg Trop Dis 2012; 6: e1829.
24. Katz N, Chaves A & Pellegrino J. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 1972; 14: 397-400.
25. Jenkins SJ & Mountford AP. Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation. Infect Immun 2005; 73: 395-402.
26. Tawill S, Le Goff L, Ali F, Blaxter M & Allen JE. Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans. Infect Immun 2004; 72: 398-407.
27. Mountford AP & Trottein F. Schistosomes in the skin: a balance between immune priming and regulation. Trends in Parasitol 2004; 20: 221-226.
28. King CL, Malhotra I, Mungai P, et al. Schistosoma haematobium-induced urinary tract morbidity correlates with increased tumor necrosis factor-alpha and diminished interleukin-10 production. J Infect Dis 2001; 184: 1176-1182.
29. McManus DP, Ross AGP, Sleigh AC, et al. Production of interleukin-10 by peripheral blood mononuclear cells from residents of a marshland area in China endemic for Schistosoma japonicum. Parasitol Int 1999; 48: 169-177.
30. Silveira AMS, Gazzinelli G, Alves-Oliveira LF, et al. Human schistosomiasis mansoni: Intensity of infection differentially affects the production of interleukin-10, interferon-gamma and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures. Trans R Soc Trop Med Hyg 2004; 98: 514-519.
31. Mutapi F, Winborn G, Midzi N, Taylor M, Mduluza T & Maizels RM. Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age. BMC Infect Dis 2007; 7: 139.
32. Thorne KJ & Mazza G. Eosinophilia, activated eosinophils and human schistosomiasis. J Cell Sci 1991; 98(Pt 3): 265-270.
33. Rothenberg ME & Hogan SP. The eosinophil. Ann R Immunol 2006; 24: 147-174.
34. Spencer LA, Szela CT, Perez SA, et al. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J of Leuk Biol 2009; 85: 117-123.
35. Hokke CH & Yazdanbakhsh M. Schistosome glycans and innate immunity. Parasite Immunol 2005; 27: 257-264.
36. Robijn ML, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH. Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs. Parasitology 2005; 130: 67-77.
37. Everts B, Hussaarts L, Driessen NN, et al. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med 2012; 209(1753-1767): S1751.