GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing ras prenylation

American Journal of Pathology

Volumn 179, Issue 6, 2011, Pages 2740-2750

  Shen, Ning ^a   Shao, Yue ^c   Lai, Shan Shan ^c   Qiao, Long ^c   Yang, Run Lin ^c   Xue, Bin ^a   Pan, Fei Yan ^c   Chen, Hua Qun ^c   Li, Chao Jun ^a,b,c  

^a NANJING UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c NANJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; EARLY GROWTH RESPONSE FACTOR 1; FARNESYL TRANS TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAS PROTEIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PRENYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; EARLY GROWTH RESPONSE PROTEIN 1; FARNESYLTRANSTRANSFERASE; FEEDBACK, PHYSIOLOGICAL; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, MUTANT STRAINS; PNEUMONIA; PRENYLATION; RAS PROTEINS; RNA, SMALL INTERFERING; SMOKE; SMOKING; TRANSCRIPTION, GENETIC;

EID: 81255124285     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.08.011     Document Type: Article

References (49)

1. X.M. Cao, G.R. Guy, V.P. Sukhatme, and Y.H. Tan Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts J Biol Chem 267 1992 1345 1349
2. P. Chavrier, M. Zerial, P. Lemaire, J. Almendral, R. Bravo, and P. Charnay A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells EMBO J 7 1988 29 35
3. A. Gashler, and V.P. Sukhatme Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors Prog Nucleic Acid Res Mol Biol 50 1995 191 224
4. S.F. Yan, D.J. Pinsky, N. Mackman, and D.M. Stern Egr-1: is it always immediate and early? J Clin Invest 105 2000 553
5. S.F. Yan, J. Lu, Y.S. Zou, J. Soh-Won, D.M. Cohen, P.M. Buttrick, D.R. Cooper, S.F. Steinberg, N. Mackman, D.J. Pinsky, and D.M. Stern Hypoxia-associated induction of early growth response-1 gene expression J Biol Chem 274 1999 15030 15040
6. M. Rolli, A. Kotlyarov, K.M. Sakamoto, M. Gaestel, and A. Neininger Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner J Biol Chem 274 1999 19559 19564
7. K.J. O'Donovan, W.G. Tourtellotte, J. Millbrandt, and J.M. Baraban The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience Trends Neurosci 22 1999 167 173 (Pubitemid 29166785)
8. C. Liu, V.M. Rangnekar, E. Adamson, and D. Mercola Suppression of growth and transformation and induction of apoptosis by EGR-1 Cancer Gene Ther 5 1998 3 28 (Pubitemid 128639987)
9. C.P. Lim, N. Jain, and X. Cao Stress-induced immediate-early gene, egr-1, involves activation of p 38/JNK 1 Oncogene 16 1998 2915 2926 (Pubitemid 28383276)
10. R.P. Huang, and E.D. Adamson A biological role for Egr-1 in cell survival following ultra-violet irradiation Oncogene 10 1995 467 475
11. R. Datta, N. Taneja, V.P. Sukhatme, S.A. Qureshi, R. Weichselbaum, and D.W. Kufe Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation Proc Natl Acad Sci USA 90 1993 2419 2422 (Pubitemid 23078638)
12. C. Skerka, E.L. Decker, and P.F. Zipfel A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1 J Biol Chem 270 1995 22500 22506
13. B. Kramer, A. Meichle, G. Hensel, P. Charnay, and M. Kronke Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter Biochim Biophys Acta 1219 1994 413 421 (Pubitemid 24319701)
14. J.X. Lin, and W.J. Leonard The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites Mol Cell Biol 17 1997 3714 3722 (Pubitemid 27281846)
15. A. Dinkel, W.K. Aicher, C. Haas, P.F. Zipfel, H.H. Peter, and H. Eibel Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells J Immunol 159 1997 2678 2684 (Pubitemid 127681286)
16. J.S. Maltzman, J.A. Carmen, and J.G. Monroe Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1 J Exp Med 183 1996 1747 1759
17. W. Ning, Y. Dong, J. Sun, C. Li, M.A. Matthay, C.A. Feghali-Bostwick, and A.M. Choi Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts Am J Respir Cell Mol Biol 36 2007 480 490 (Pubitemid 46623007)
18. C.J. Li, W. Ning, M.A. Matthay, C.A. Feghali-Bostwick, and A.M.K. Choi MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production Am J Physiol Lung Cell Mol Physiol 292 2007 L1297 L1303
19. W. Ning, C.J. Li, N. Kaminski, C.A. Feghali-Bostwick, S.M. Alber, Y.P. Di, S.L. Otterbein, R. Song, S. Hayashi, and Z. Zhou Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease Proc Natl Acad Sci U S A 101 2004 14895 14900 (Pubitemid 39410771)
20. H.C. Rilling, E. Breunger, W.W. Epstein, and P.F. Crain Prenylated proteins: the structure of the isoprenoid group Science 247 1990 318 320 (Pubitemid 120031322)
21. C.C. Farnsworth, M.H. Gelb, and J.A. Glomset Identification of geranylgeranyl-modified proteins in HeLa cells Science 247 1990 320 322
22. C.C. Farnsworth, S.L. Wolda, M.H. Gelb, and J.A. Glomset Human lamin B contains a farnesylated cysteine residue J Biol Chem 264 1989 20422 20429 (Pubitemid 20009228)
23. L.P. Wright, and M.R. Philips Thematic review series: lipid posttranslational modifications CAAX modification and membrane targeting of Ras J Lipid Res 47 2006 883 891
24. F.L. Zhang, and P.J. Casey Protein prenylation: molecular mechanisms and functional consequences Annu Rev Biochem 65 1996 241 269 (Pubitemid 26250610)
25. J.A. Glomset, and C.C. Farnsworth Role of protein modification reactions in programming interactions between Ras-related GTPases and cell membranes Annu Rev Cell Biol 10 1994 181 205 (Pubitemid 24372820)
26. N. Shen, T. Gong, J.D. Wang, F.L. Meng, L. Qiao, R.L. Yang, B. Xue, F.Y. Pan, X.J. Zhou, and H.Q. Chen Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling The Am J Pathol 178 2011 110 118
27. M. Vayssier-Taussat, T. Camilli, Y. Aron, C. Meplan, P. Hainaut, B.S. Polla, and B. Weksler Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses Am J Physiol Heart Circ Physiol 280 2001 H1293 H1300
28. Y. Levkovitz, and J.M. Baraban A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation J Neurosci 21 2001 5893 5901 (Pubitemid 32737722)
29. A.M. Wang, M.V. Doyle, and D.F. Mark Quantitation of mRNA by the polymerase chain reaction Proc Natl Acad Sci U S A 86 1989 97171921
30. C.B. Chiribau, L. Cheng, I.C. Cucoranu, Y.S. Yu, R.E. Clempus, and D. Sorescu FoxO3A regulates peroxiredoxin III expression in human cardiac fibroblasts J Biol Chem 283 2008 8211 8217
31. E. Kim, P. Ambroziak, J.C. Otto, B. Taylor, M. Ashby, K. Shannon, P.J. Casey, and S.G. Young Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells J Biol Chem 274 1999 8383 8390 (Pubitemid 29164626)
32. M.L. Goalstone, J.W. Leitner, I. Golovchenko, M.R. Stjernholm, M. Cormont, Y. Le Marchand-Brustel, and B. Draznin Insulin promotes phosphorylation and activation of geranylgeranyltransferase II Studies with geranylgeranylation of rab-3 and rab-4 J Biol Chem 274 1999 2880 2884 (Pubitemid 29075373)
33. S. Mishra, T. Fujita, V.N. Lama, D. Nam, H. Liao, M. Okada, K. Minamoto, Y. Yoshikawa, H. Harada, and D.J. Pinsky Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes Proc Natl Acad Sci USA 103 2006 5191 5196
34. I. Rahman Oxidative stress in pathogenesis of chronic obstructive pulmonary disease Cell Biochem Biophys 43 2005 167 188 (Pubitemid 41095282)
35. L.K. McNeil, T.K. Starr, and K.A. Hogquist A requirement for sustained ERK signaling during thymocyte positive selection in vivo Proc Natl Acad Sci USA 102 2005 13574 13579 (Pubitemid 41420890)
36. L.O. Murphy, J.P. MacKeigan, and J. Blenis A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration Mol Cell Biol 24 2004 144 153 (Pubitemid 38010042)
37. B.A. Mercer, N. Kolesnikova, J. Sonett, and J. D'Armiento Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke J Biol Chem 279 2004 17690 17696 (Pubitemid 38568101)
38. V. Baron, S. Duss, J. Rhim, and D. Mercola Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice Ann NY Acad Sci 1002 2003 197 216 (Pubitemid 38253343)
39. P.J. Roberts, and C.J. Der Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 2007 3291 3310 (Pubitemid 46763022)
40. J.A. McCubrey, L.S. Steelman, W.H. Chappell, S.L. Abrams, E.W. Wong, F. Chang, B. Lehmann, D.M. Terrian, M. Milella, and A. Tafuri Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance Biochim Biophys Acta 1773 2007 1263 1284 (Pubitemid 47125967)
41. A.A. Adjei The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy Clin Lung Cancer 7 2005 221 223 (Pubitemid 43279873)
42. S.E. Kim, T.T.T. Thuy, J.H. Lee, J.Y. Ro, Y.A. Bae, Y. Kong, J.Y. Ahn, D.S. Lee, Y.M. Oh, and S.D. Lee Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract Exp Mol Med 41 2009 277 287
43. N. Shen, X. Yu, F.Y. Pan, X. Gao, B. Xue, and C.J. Li An early response transcription factor Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism J Biol Chem 286 2011 14508 14515
44. L.F. Black, and F. Kueppers Alpha1-antitrypsin deficiency in nonsmokers Am Rev Respir Dis 117 1978 421
45. J.E. Gadek, G.A. Fells, and R.G. Crystal Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans Science 206 1979 1315 1316 (Pubitemid 10170021)
46. G.W. Hunninghake, and R.G. Crystal Cigarette smoking and lung destruction Accumulation of neutrophils in the lungs of cigarette smokers Am Rev Respir Dis 128 1983 833 838 (Pubitemid 14231334)
47. E.D. Janus, N.T. Phillips, and R.W. Carrell Smoking, lung function, and alpha 1-antitrypsin deficiency Lancet 1 1985 152 154 (Pubitemid 15152477)
48. J.W. Park, J.Y. Yoon, Y.J. Kim, S.Y. Kyung, S.P. Lee, S.H. Jeong, and C. Moon Extracellular signal-regulated kinase (ERK) inhibition attenuates cigarette smoke extract (CSE) induced-death inducing signaling complex (DISC) formation in human lung fibroblasts (MRC-5) cells J Toxicol Sci 35 2010 33 39
49. H. Chen, L. Wang, T. Gong, Y. Yu, C. Zhu, F. Li, L. Wang, and C. Li EGR-1 regulates Ho-1 expression induced by cigarette smoke Biochem Biophys Res Commun 396 2010 388 393