Sm16, a major component of Schistosoma mansoni cercarial excretory/secretory products, prevents macrophage classical activation and delays antigen processing

Parasites and Vectors

Volumn 8, Issue 1, 2015, Pages

  Sanin, David E ^a   Mountford, Adrian P ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Cercarial excretory secretory products; Helminths; Macrophage activation; Macrophages; Schistosoma mansoni; Toll like receptors

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P40; RECOMBINANT PROTEIN; SM16; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; HELMINTH PROTEIN; LIGAND; PARASITE ANTIGEN; SM16 PROTEIN, SCHISTOSOMA MANSONI; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL MIGRATION; CERCARIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; FEMALE; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SIGNAL TRANSDUCTION; SKIN; ULTRACENTRIFUGATION; ANIMAL; DRUG EFFECTS; GENETICS; MACROPHAGE; METABOLISM;

MURINAE; SCHISTOSOMA MANSONI; VERMES;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, HELMINTH; HELMINTH PROTEINS; LIGANDS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; SCHISTOSOMA MANSONI; TOLL-LIKE RECEPTORS;

EID: 84925349518     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/s13071-014-0608-1     Document Type: Article

References (37)

1. Curwen RS, Ashton PD, Sundaralingam S, Wilson RA: Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Mol Cell Proteomics 2006, 5:835-844.
2. Wilson RA: Virulence factors of schistosomes. Microbes Infect 2012, 14:1442-1450.
3. Paveley RA, Aynsley SA, Cook PC, Turner JD, Mountford AP: Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells. PLoS Negl Trop Dis 2009, 3: e528.
4. McKerrow JH, Salter J: Invasion of skin by Schistosoma cercariae. Trends Parasitol 2002, 18:193-195.
5. Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH: Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. J Biol Chem 2000, 275:38667-38673.
6. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH: Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics 2005, 4:1862-1875.
7. Jenkins SJ, Hewitson JP, Ferret-Bernard S, Mountford AP: Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways. Int Immunol 2005, 17:1409-1418.
8. Jenkins SJ, Hewitson JP, Jenkins GR, Mountford AP: Modulation of the host's immune response by schistosome larvae. Parasite Immunol 2005, 27:385-393.
9. Holmfeldt P, Brannstrom K, Sellin ME, Segerman B, Carlsson SR, Gullberg M: The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 is a membrane-binding protein that lacks the proposed microtubuleregulatory activity. Mol Biochem Parasitol 2007, 156:225-234.
10. Brännström K, Sellin ME, Holmfeldt P, Brattsand M, Gullberg M: The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 assembles into a nine-subunit oligomer with potential To inhibit Toll-like receptor signaling. Infect Immun 2009, 77:1144-1154.
11. Valle C, Festucci A, Calogero A, Macri P, Mecozzi B, Liberti P, Cioli D: Stage-specific expression of a Schistosoma mansoni polypeptide similar to the vertebrate regulatory protein stathmin. J Biol Chem 1999, 274:33869-33874.
12. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999, 11:443-451.
13. Bailey MJ, Lacey DC, de Kok BV, Veith PD, Reynolds EC, Hamilton JA: Extracellular proteomes of M-CSF (CSF-1) and GM-CSF-dependent macrophages. Immunol Cell Biol 2011, 89:283-293.
14. Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP: The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNgamma production. Int J Parasitol 2011, 41:1335-1345.
15. Medina EA, Morris IR, Berton MT: Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain. J Immunol 2010, 185:7562-7572.
16. Saraiva M, Christensen JR, Tsytsykova AV, Goldfeld AE, Ley SC, Kioussis D, O'Garra A: Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol 2005, 175:1041-1046.
17. Beas AO, Taupin V, Teodorof C, Nguyen LT, Garcia-Marcos M, Farquhar MG: Galphas promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell 2012, 23:4623-4634.
18. Humphries WH, Szymanski CJ, Payne CK: Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran. PLoS One 2011, 6: e26626.
19. de Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, Wierenga EA, Yazdanbakhsh M, Kapsenberg ML: Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 2002, 168:1704-1709.
20. Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T, Pulendran B: Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 2003, 171:4984-4989.
21. Hogg KG, Kumkate S, Anderson S, Mountford AP: Interleukin-12 p40 secretion by cutaneous CD11c + and F4/80+ cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni. Infect Immun 2003, 71:3563-3571.
22. Yang Z, Zhang X, Darrah P, Mosser D: The regulation of Th1 responses by the p38 MAPK. J Immunol 2010, 185:6205-6213.
23. Cook PC, Aynsley SA, Turner JD, Jenkins GR, Van Rooijen N, Leeto M, Brombacher F, Mountford AP: Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog 2011, 7: e1001323.
24. Dvorak J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR: Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol 2010, 170:37-40.
25. Barron L, Wynn TA: Macrophage activation governs schistosomiasisinduced inflammation and fibrosis. Eur J Immunol 2011, 41:2509-2514.
26. Benoit M, Desnues B, Mege JL: Macrophage polarization in bacterial infections. J Immunol 2008, 181:3733-3739.
27. Hokke CH, Deelder AM: Schistosome glycoconjugates in host-parasite interplay. Glycoconj J 2001, 18:573-587.
28. Hokke CH, Yazdanbakhsh M: Schistosome glycans and innate immunity. Parasite Immunol 2005, 27:257-264.
29. Tundup S, Srivastava L, Harn DA Jr: Polarization of host immune responses by helminth-expressed glycans. Ann N Y Acad Sci 2012, 1253: E1-E13.
30. Jang-Lee J, Curwen RS, Ashton PD, Tissot B, Mathieson W, Panico M, Dell A, Wilson RA, Haslam SM: Glycomics analysis of Schistosoma mansoni egg and cercarial secretions. Mol Cell Proteomics 2007, 6:1485-1499.
31. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511.
32. Pineda MA, Lumb F, Harnett MM, Harnett W: ES-62, a therapeutic antiinflammatory agent evolved by the filarial nematode Acanthocheilonema viteae. Mol Biochem Parasitol 2014, 194:1-8.
33. Schmerk CL, Valvano MA: Burkholderia multivorans survival and trafficking within macrophages. J Med Microbiol 2013, 62:173-184.
34. Johnston SA, May RC: The human fungal pathogen Cryptococcus neoformans escapes macrophages by a phagosome emptying mechanism that is inhibited by Arp2/3 complex-mediated actin polymerisation. PLoS Pathog 2010, 6: e1001041.
35. Blander JM, Medzhitov R: Regulation of phagosome maturation by signals from toll-like receptors. Science 2004, 304:1014-1018.
36. Kagan JC, Iwasaki A: Phagosome as the organelle linking innate and adaptive immunity. Traffic 2012, 13:1053-1061.
37. Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC: A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell 2014, 156:705-716.