Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro

Neurochemistry International

Volumn 87, Issue , 2015, Pages 66-76

  Hu, Xiao Long ^a,b   Guo, Li Ping ^b   Song, Qi ^b   Zhang, Qiao ^b   Chen, Ying ^a   Wang, Jian ^b   Meng, Wei Hong ^a   Zhao, Qing Chun ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Kukoamine B; Molecular docking; NADPH oxidase; NMDA receptors; Oxidative stress; SH SY5Y cells

Indexed keywords

ALKALOID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HERBACEOUS AGENT; KUKOAMINE B; LACTATE DEHYDROGENASE; MALONALDEHYDE; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; APOCYNIN; CAFFEIC ACID DERIVATIVE; CALCIUM; DIZOCILPINE MALEATE; N METHYLASPARTIC ACID; SPERMINE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CELL DEATH; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME RELEASE; IN VITRO STUDY; MOLECULAR DOCKING; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANALOGS AND DERIVATIVES; DRUG EFFECTS; ENZYMOLOGY; HUMAN; ION TRANSPORT; METABOLISM; NERVE CELL; TUMOR CELL LINE;

ACETOPHENONES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CAFFEIC ACIDS; CALCIUM; CELL LINE, TUMOR; DIZOCILPINE MALEATE; HUMANS; IN VITRO TECHNIQUES; ION TRANSPORT; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MATRIX METALLOPROTEINASES; N-METHYLASPARTATE; NEURONS; REACTIVE OXYGEN SPECIES; SPERMINE; SUPEROXIDE DISMUTASE;

EID: 84937640643     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.06.001     Document Type: Article

References (37)

1. S.M. Aamodt, and M. Constantine-Paton The role of neural activity in synaptic development and its implications for adult brain function Adv. Neurol 79 1998 133 144
2. R.M. Adibhatla, and J.F. Hatcher Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia Free Radic. Biol. Med 40 2006 376 387
3. R.S. Akundi, and et al. 1-Trichloromethy 1, 2, 3, 4-tetrahydro-β-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines Ann. N. Y. Acad. Sci 1010 2003 304 306
4. C.N. Anderson, and A.M. Tolkovsky A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside J. Neurosci 19 1999 664 673
5. J.L. Banko, and et al. NMDA receptor activation results in PKA-and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1 J. Neurochem 91 2004 462 470
6. C. Barkus, and et al. Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion Eur. J. Pharmacol 626 2010 49 56
7. T.V. Bliss, and G.L. Collingridge A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 1993 31 39
8. T. Borsello, and G. Forloni JNK signalling: a possible target to prevent neurodegeneration Curr. Pharm. Des 13 2007 1875 1886
9. A.M. Brennan, and et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation Nat. Neurosci 12 2009 857 863
10. Chen W., and et al. Macrophage polarization induced by neuropeptide methionine enkephalin (MENK) promotes tumoricidal responses Cancer Immunol. Immunother 61 2012 1755 1768
11. M.T. Corasaniti, and et al. Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro Br. J. Pharmacol 151 2007 518 529
12. P. Delgado, and et al. Computational approaches for evaluating the effect of sequence variations and the intrinsically disordered C-terminal region of the Helicobacter pylori CagA protein on the interaction with tyrosine kinase Src J. Mol. Model 20 2014 2406
13. G. Deuschl, and et al. A randomized trial of deep-brain stimulation for Parkinson's disease N. Engl. J. Med 355 2006 1289
14. M. Enari, and et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 391 1998 43 50
15. Fang Y.Q., and et al. Investigating dynamic structural and mechanical changes of neuroblastoma cells associated with glutamate-mediated neurodegeneration Sci. Rep 4 2014 7074
16. A.P. Halestrap, and C. Brenner The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death Curr. Med. Chem 10 2003 1507 1525
17. G.E. Hardingham, and H. Bading The Yin and Yang of NMDA receptor signaling Trends Neurosci 26 2003 81 89
18. G.E. Hardingham, and et al. A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication Nat. Neurosci 4 2001 565 566
19. H. Kaphzan, and et al. NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus PLoS ONE 1 2006 e138
20. E. Karakas, and et al. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors Nature 475 2011 249 253
21. I.I. Kruman, and M.P. Mattson Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis J. Neurochem 72 1999 529 540
22. M. Lasa, and et al. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol. Cell. Biol 22 2002 7802 7811
23. P. Malherbe, and et al. Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket J. Pharmacol. Exp. Ther 307 2003 897 905
24. L. Marinelli, and et al. Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding ChemMedChem 2 2007 1498 1510
25. L. Meijer, and et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins Chem. Biol 10 2003 1255 1266
26. V. Miquel, and P. Serge Targeting programmed cell death in neurodegenerative diseases Nat. Rev. Neurosci 4 2003 365 375
27. J. Naarala, and et al. Blocking of carbachol-induced calcium mobilization by glutamate receptor antagonists Neurosci. Res. Commun 30 2006 1 6
28. S. Nakanishi Molecular diversity of glutamate receptors and implications for brain function Science 258 1992 597 603
29. D.A. Nita, and et al. Oxidative damage following cerebral ischemia depends on reperfusion-a biochemical study in rat J. Cell. Mol. Med 5 2001 163 170
30. S. Paul, and J.A. Connor NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling J. Neurochem 114 2010 1107 1118
31. S. Paul, and et al. The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala Biol. Psychiatry 61 2007 1049 1061
32. D. Petroni, and et al. Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-asparate receptor antagonist in human neuroblastoma (SH-SY5Y) cells Environ. Toxicol 28 2013 700 706
33. S. Sugunadevi, and et al. Pharmacophore based virtual screening, molecular docking studies to design potent heat shock protein 90 inhibitors Eur. J. Med. Chem 46 2011 2937 2947
34. Tan J.W., and et al. Neuroprotective effects of biochanin A against glutamate-induced cytotoxicity in PC12 cells via apoptosis inhibition Neurochem. Res 38 2013 512 518
35. R.J. Wenthold, and et al. Trafficking of NMDA receptors Annu. Rev. Pharmacol. Toxicol 43 2003 335 358
36. Zhao L., and et al. Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice Brain Res 1503 2013 78 88
37. Zhou F., and et al. MLK3-MKK316-P38MAPK cascades following N-methyl-D-asparate receptor contributes to amyloid-β-peptide induced apoptosis in SH-SY5Y cells J. Neurosci. Res 92 2014 808 817