Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-aspartate antagonist in human neuroblastoma (SHSY5Y) cells

Environmental Toxicology

Volumn 28, Issue 12, 2013, Pages 700-706

  Petroni, Daniel ^a   Tsai, Jeffrey ^a   Mondal, Debasis ^a   George, William ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxicity; Glutamate; Methylmercury; SH SY5Y cells; Tau hyperphosphorylation

Indexed keywords

GLUTAMATE; INTRACELLULAR CALCIUM; METHYL MERCURY; N-METHYL-D-ASPARTATE; NEUROBLASTOMA CELL (SH SY5Y); NEUROLOGICAL DISEASE; SH-SY5Y CELLS; TAU HYPERPHOSPHORYLATION;

CELL CULTURE; CHELATION; CYTOTOXICITY; NEUROLOGY; NEURONS; PHOSPHORYLATION; PLANTS (BOTANY); TOXICITY;

CELLS;

DIZOCILPINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTAMIC ACID; METHYLMERCURY; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TAU PROTEIN;

CALCIUM; CELL ORGANELLE; DISEASE; GROWTH; HOMEOSTASIS; METHYLMERCURY; PROTEIN; SURVIVAL; TOXICITY;

ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL GROWTH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NERVE CELL LESION; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TAUOPATHY;

CYTOTOXICITY; GLUTAMATE; METHYLMERCURY; SH-SY5Y CELLS; TAU HYPERPHOSPHORYLATION;

CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; CHELATING AGENTS; DIZOCILPINE MALEATE; EGTAZIC ACID; GLUTAMIC ACID; HUMANS; METHYLMERCURY COMPOUNDS; NEUROBLASTOMA; PHOSPHORYLATION; RECEPTORS, N-METHYL-D-ASPARTATE; TAU PROTEINS;

EID: 84887167472     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20765     Document Type: Article

References (24)

1. Adamec E, Mohan P, Vonsattel JP, Nixon RA. 2002. Calpain activation in neurodegenerative diseases: Confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathol 104:92-104.
2. Atchison WD, Hare MF. 1994. Mechanisms of methylmercury-induced neurotoxicity. FASEB J 8:622-629.
3. Blandini F, Greenamyre JT, Nappi G. 1996a. The role of glutamate in the pathophysiology of Parkinson's disease. Funct Neurol 11:3-15.
4. Blandini F, Porter RH, Greenamyre JT. 1996b. Glutamate and Parkinson's disease. Mol Neurobiol 12:73-94.
5. Dorea JG. 2008. Persistent, bioaccumulative and toxic substances in fish: Human health considerations. Sci Total Environ 400:93-114.
6. Ermak G, Davies KJ. 2002. Calcium and oxidative stress: From cell signaling to cell death. Mol Immunol 38:713-721.
7. U.S. Food and Drug Administration (FDA). 2004. Mercury levels in commercial fish and shellfish (1990-2010). http://www.fda.gov/food/foodsafety/product-specificinformation/seafood/foodbornepathogenscontaminants/methylmercury/ucm115644.htm.
8. Grynspan F, Griffin WB, Mohan PS, Shea TB, Nixon RA. 1997. Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: Comparison with the human brain calpain system. J Neurosci Res 48:181-191.
9. Hynd MR, Scott HL, Dodd PR. 2004. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 45:583-595.
10. Jamsa A, Backstrom A, Gustafsson E, Dehvari N, Hiller G, Cowburn RF, Vasange M. 2006. Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. Biochem Biophys Res Commun 345:324-331.
11. Juarez BI, Portillo-Salazar H, Gonzalez-Amaro R, Mandeville P, Aguirre JR, Jimenez ME. 2005. Participation of N-methyl-D-aspartate receptors on methylmercury-induced DNA damage in rat frontal cortex. Toxicology 207:223-229.
12. Lafon-Cazal M, Pietri S, Culcasi M, Bockaert J. 1993. NMDA-dependent superoxide production and neurotoxicity. Nature 364:535-537.
13. Limke TL, Otero-Montanez JK, Atchison WD. 2003. Evidence for interactions between intracellular calcium stores during methylmercury-induced intracellular calcium dysregulation in rat cerebellar granule neurons. J Pharmacol Exp Ther 304:949-958.
14. Monaco EAIII. 2004. Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease. Curr Alzheimer Res 1:33-38.
15. Moretto MB, Funchal C, Santos AQ, Gottfried C, Boff B, Zeni G, Pureur RP, Souza DO, Wofchuk S, Rocha JB. 2005. Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+. Toxicology.214:57-66.
16. Naarala J, Nykvist P, Tuomala M, Savolainen K. 1993. Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells. FEBS Lett 330:222-226.
17. Ndountse LT, Chan HM. 2008. Methylmercury increases N-methyl-D-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity. Toxicology 249:251-255.
18. Petroni D, Tsai J, Agrawal K, Mondal D, George W. 2011Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells. Environ Toxicol. Jan 20. doi: 10.1002/tox.20672. [Epub ahead of print] PubMed PMID: 21254321.
19. Shipp AM, Gentry PR, Lawrence G, Van Landingham C, Covington T, Clewell HJ, Gribben K, Crump K. 2000. Determination of a site-specific reference dose for methylmercury for fish-eating populations. Toxicol Ind Health 16:335-438.
20. Sun ZW, Zhang L, Zhu SJ, Chen WC, Mei B. 2010. Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage. Neurosci Bull 26:8-16.
21. Taylor JR. 1984. Neurotoxicity of certain environmental substances. Clin Lab Med 4:489-497.
22. Tchounwou PB, Ayensu WK, Ninashvili N, Sutton D. 2003. Environmental exposure to mercury and its toxicopathologic implications for public health. Environ Toxicol 18:149-175.
23. USGS. 2001. Mercury in US Coal-Abundance, Distribution and Modes of Occurene. USGS Fact Sheet FS-095-01.
24. Zeron MM, Chen N, Moshaver A, Lee AT, Wellington CL, Hayden MR, Raymond LA. 2001. Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci 17:41-53.