Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

Developmental Cell

Volumn 33, Issue 6, 2015, Pages 729-736

  Gordon, Wendy R ^a,b   Zimmerman, Brandon ^a,c   He, Li ^a   Miles, Laura J ^a,c   Huang, Jiuhong ^a,f   Tiyanont, Kittichoat ^c   McArthur, Debbie G ^c   Aster, Jon C ^d   Perrimon, Norbert ^a,e   Loparo, Joseph J ^a   Blacklow, Stephen C ^a,c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL RECEPTOR; FK 506 BINDING PROTEIN; NOTCH1 RECEPTOR; ADAM PROTEIN; LIGAND; NOTCH RECEPTOR; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOCYTOSIS; GENE EXPRESSION; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; ARTIFICIAL CELL; BIOLOGICAL MODEL; BIOMECHANICS; CELL LINE; CHEMISTRY; HEK293 CELL LINE; HUMAN; METABOLISM;

ADAM PROTEINS; ALLOSTERIC REGULATION; ANIMALS; ARTIFICIAL CELLS; BIOMECHANICAL PHENOMENA; CELL LINE; ENDOCYTOSIS; HEK293 CELLS; HUMANS; LIGANDS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; PROTEOLYSIS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84937638491     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2015.05.004     Document Type: Article

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