Mechanoenzymatic cleavage of the ultralarge vascular protein von willebrand factor

Science

Volumn 324, Issue 5932, 2009, Pages 1330-1334

  Zhang, Xiaohui ^a,c   Halvorsen, Kenneth ^b   Zhang, Cheng Zhong ^a   Wong, Wesley P ^b   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMER; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

AGGREGATION; BLOOD; ENZYME; ENZYME ACTIVITY; PROTEIN; SECRETION; SHEAR STRESS; SIZE DISTRIBUTION;

ARTERIOLE; ARTICLE; BLEEDING; HEMOSTASIS; HYDRODYNAMICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SHEAR FLOW; SHEAR STRENGTH; TENSILE STRENGTH; THROMBOCYTE AGGREGATION; THROMBOSIS; VASCULARIZATION;

ADAM PROTEINS; BINDING SITES; BLOOD COAGULATION; HEMOSTASIS; HUMANS; KINETICS; MECHANICAL PHENOMENA; OPTICAL TWEEZERS; PLATELET AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL; THERMODYNAMICS; VON WILLEBRAND FACTOR;

EID: 66749099068     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1170905     Document Type: Article

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