Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia

Schizophrenia Bulletin

Volumn 39, Issue 2, 2013, Pages 396-406

  Wong, Jenny ^a,b,c   Duncan, Carlotta E ^a,b   Beveridge, Natalie J ^a,d   Webster, Maree J ^e   Cairns, Murray J ^a,d   Shannon Weickert, Cynthia ^a,b,c  

^a SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^b NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF NEWCASTLE   (Australia)

^e Stanley Medical Research Institute   (United States)

Author keywords

cortex; development; DLPFC; GABAergic; human; interneurons; miRNA; NPAS3; postmortem; schizophrenia

Indexed keywords

LUCIFERASE; MESSENGER RNA; MICRORNA; MICRORNA 17; NEURONAL PER ARNT SIM DOMAIN PROTEIN 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; BRAIN DEVELOPMENT; CASE REPORT; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; POSTNATAL DEVELOPMENT; PREFRONTAL CORTEX; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SCHOOL CHILD; UNTRANSLATED REGION; WESTERN BLOTTING;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFANT; MALE; MICRORNAS; MIDDLE AGED; NERVE TISSUE PROTEINS; PREFRONTAL CORTEX; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SCHIZOPHRENIA; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84874509113     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbr177     Document Type: Article

References (29)

1. Kamnasaran D, Muir WJ, Ferguson-Smith MA, Cox DW. Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J Med Genet. 2003;40:325-332. (Pubitemid 36613468)
2. Gilles-Gonzalez MA, Gonzalez G. Signal transduction by heme-containing PAS-domain proteins. J Appl Physiol. 2004;96:774-783. (Pubitemid 38140186)
3. Gilles-Gonzalez MA, Gonzalez G. Heme-based sensors: defining characteristics, recent developments, and regulatory hypotheses. J Inorg Biochem. 2005;99:1-22. (Pubitemid 39642968)
4. DeLisi LE, Craddock NJ, Detera-Wadleigh S, et al. Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999. Am J Med Genet. 2000;96:434-449.
5. Craddock N, Lendon C. Chromosome Workshop: chromosomes 11, 14, and 15. Am J Med Genet. 1999;88:244-254.
6. Chiu YF, McGrath JA, Thornquist MH, et al. Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q. Mol Psychiatry. 2002;7:658-664.
7. Pickard BS, Christoforou A, Thomson PA, et al. Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol Psychiatry. 2009;14:874-884.
8. Huang J, Perlis RH, Lee PH, et al. Cross-Disorder Genomewide Analysis of Schizophrenia, Bipolar Disorder, and Depression. Am J Psychiatry. 2010;167:1254-1263.
9. Brunskill EW, Ehrman LA, Williams MT, et al. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur J Neurosci. 2005;22:1265-1276. (Pubitemid 41442400)
10. Pickard BS, Malloy MP, Porteous DJ, Blackwood DH, Muir WJ. Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. Am J Med Genet B Neuropsychiatr Genet. 2005;136B:26-32. (Pubitemid 40917524)
11. Erbel-Sieler C, Dudley C, Zhou Y, et al. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci USA. 2004;101:13648-13653. (Pubitemid 39238457)
12. Guidotti A, Auta J, Davis JM, et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry. 2000;57:1061-1069.
13. Impagnatiello F, Guidotti AR, Pesold C, et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci USA. 1998;95:15718-15723. (Pubitemid 29018766)
14. Fung SJ, Webster MJ, Sivagnanasundaram S, Duncan C, Weickert CS. Expression of interneuron markers in the dorsolateral prefrontal cortex of the developing human and in schizophrenia. Am J Psychiatry. 2010;167:1479-1488.
15. Eastwood SL, Harrison PJ. Cellular basis of reduced cortical reelin expression in schizophrenia. Am J Psychiatry. 2006;163:540-542. (Pubitemid 44469402)
16. Brunskill EW, Witte DP, Shreiner AB, Potter SS. Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system. Mech Dev 1999;88:237-241. (Pubitemid 29479311)
17. Weickert CS, Sheedy D, Rothmond DA, et al. Selection of reference gene expression in a schizophrenia brain cohort. Aust N Z J Psychiatry 2010;44:59-70.
18. Wong J, Webster MJ, Cassano H, Weickert CS. Changes in alternative brain-derived neurotrophic factor transcript expression in the developing human prefrontal cortex. Eur J Neurosci 2009;29:1311-1322.
19. Duncan CE, Webster MJ, Rothmond DA, Bahn S, Elashoff M, Shannon Weickert C. Prefrontal GABA(A) receptor alpha-subunit expression in normal postnatal human development and schizophrenia. J Psychiatr Res 2010;44:673-681.
20. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;3: RESEARCH0034.
21. Beveridge NJ, Gardiner E, Carroll AP, Tooney PA, Cairns MJ. Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol Psychiatry 2010;15: 1176-1189.
22. Kozlovsky N, Shanon-Weickert C, Tomaskovic-Crook E, Kleinman JE, Belmaker RH, Agam G. Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients. J Neural Transm 2004;111: 1583-1592. (Pubitemid 40064475)
23. Weickert CS, Hyde TM, Lipska BK, Herman MM, Weinberger DR, Kleinman JE. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry 2003;8:592-610. (Pubitemid 36898018)
24. Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ. Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation. Cell Signal 2009;21:1837-1845.
25. Sha L, MacIntyre L, Machell JA, et al. Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Mol Psychiatry 2011; Epub.
26. Fung SJ, Webster MJ, Sivagnanasundaram S, Duncan C, Weickert CS. Expression of interneuron markers in the dorsolateral prefrontal cortex of the developing human and in schizophrenia. Am J Psychiatry 2009;167:1479-1488.
27. Hashimoto T, Volk DW, Eggan SM, et al. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci. 2003;23:6315-6326. (Pubitemid 36875633)
28. Beasley CL, Zhang ZJ, Patten I, Reynolds GP. Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins. Biol Psychiatry. 2002;52:708-715.
29. Daviss SR, Lewis DA. Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons. Psychiatry Res. 1995;59:81-96. (Pubitemid 26024505)