Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers

Toxicological Sciences

Volumn 142, Issue 1, 2014, Pages 239-249

  Parkinson, Erika ^a   Boyd, Pete ^a   Aleksic, Maja ^b   Cubberley, Richard ^b   O'Connor, David ^c   Skipp, Paul ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c XI AN JIAOTONG LIVERPOOL UNIVERSITY   (China)

Author keywords

Contact allergy; GeLC MS MS; Proteomics; Sensitizer; Skin

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; 6 METHYLCOUMARIN; CINNAMALDEHYDE; HUMAN SERUM ALBUMIN; LYSINE; PROTEIN; STABLE ISOTOPE; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; 6-METHYLCOUMARIN; ACROLEIN; COUMARIN DERIVATIVE; HAPTEN; PROTEIN BINDING; SERUM ALBUMIN; THIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; ELECTROPHILICITY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; NUCLEOPHILICITY; OXIDATION; PROTEIN ANALYSIS; PROTEIN HAPTENATION; PROTEIN MODIFICATION; REACTION ANALYSIS; SKIN SENSITIZATION; ANALOGS AND DERIVATIVES; CHEMISTRY; CONTACT DERMATITIS; HUMAN; METABOLISM; SKIN; TANDEM MASS SPECTROMETRY;

ACROLEIN; CHROMATOGRAPHY, LIQUID; COUMARINS; DERMATITIS, CONTACT; DINITROCHLOROBENZENE; HAPTENS; HUMANS; ISOTOPE LABELING; PROTEIN BINDING; SERUM ALBUMIN; SKIN; TANDEM MASS SPECTROMETRY; THIAZOLES;

EID: 84937562080     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu168     Document Type: Article

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