-
1
-
-
34548805504
-
Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions
-
Kalgutkar, A. S., Obach, R. S., and Maurer, T. S. (2007) Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Curr. Drug Metab. 8, 407-447.
-
(2007)
Curr. Drug Metab
, vol.8
, pp. 407-447
-
-
Kalgutkar, A.S.1
Obach, R.S.2
Maurer, T.S.3
-
2
-
-
33847081148
-
Idiosyncratic drug reactions: Current understanding
-
Uetrecht, J. (2007) Idiosyncratic drug reactions: current understanding. Annu. Rev. Pharmacol. Toxicol. 47, 513-539.
-
(2007)
Annu. Rev. Pharmacol. Toxicol
, vol.47
, pp. 513-539
-
-
Uetrecht, J.1
-
3
-
-
18944401259
-
Elucidating mechanisms of drug-induced toxicity
-
Liebler, D. C., and Guengerich, F. P. (2005) Elucidating mechanisms of drug-induced toxicity. Nat. Rev. Drug Discovery 4, 410-420.
-
(2005)
Nat. Rev. Drug Discovery
, vol.4
, pp. 410-420
-
-
Liebler, D.C.1
Guengerich, F.P.2
-
4
-
-
0035793373
-
Metabolic activation in drug allergies
-
Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., and Pirmohamed, M. (2001) Metabolic activation in drug allergies. Toxicology 158, 11-23.
-
(2001)
Toxicology
, vol.158
, pp. 11-23
-
-
Park, B.K.1
Naisbitt, D.J.2
Gordon, S.F.3
Kitteringham, N.R.4
Pirmohamed, M.5
-
5
-
-
33744496005
-
The poisons within: Application of toxicity mechanisms to fundamental disease processes
-
Liebler, D. C. (2006) The poisons within: Application of toxicity mechanisms to fundamental disease processes. Chem. Res. Toxicol. 19, 610-613.
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 610-613
-
-
Liebler, D.C.1
-
6
-
-
13844319935
-
Drug bioactivation, covalent binding to target proteins and toxicity relevance
-
Zhou, S., Chan, E., Duan, W., Huang, M., and Chen, Y. Z. (2005) Drug bioactivation, covalent binding to target proteins and toxicity relevance. Drug Metab. Rev. 37, 41-213.
-
(2005)
Drug Metab. Rev
, vol.37
, pp. 41-213
-
-
Zhou, S.1
Chan, E.2
Duan, W.3
Huang, M.4
Chen, Y.Z.5
-
7
-
-
37849042912
-
Minimizing metabolic activation during pharmaceutical lead optimization: Progress, knowledge gaps and future directions
-
Kumar, S., Kassahun, K., Tschirret-Guth, R. A., Mitra, K., and Baillie, T. A. (2008) Minimizing metabolic activation during pharmaceutical lead optimization: Progress, knowledge gaps and future directions. Curr. Opin. Drug Discovery Dev. 11, 43-52.
-
(2008)
Curr. Opin. Drug Discovery Dev
, vol.11
, pp. 43-52
-
-
Kumar, S.1
Kassahun, K.2
Tschirret-Guth, R.A.3
Mitra, K.4
Baillie, T.A.5
-
8
-
-
1642281756
-
Drug-protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
-
Evans, D. C., Watt, A. P., Nicoll-Griffith, D. A., and Baillie, T. A. (2004) Drug-protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development. Chem. Res. Toxicol. 17, 3-16.
-
(2004)
Chem. Res. Toxicol
, vol.17
, pp. 3-16
-
-
Evans, D.C.1
Watt, A.P.2
Nicoll-Griffith, D.A.3
Baillie, T.A.4
-
9
-
-
0027205012
-
Mass spectrometry in the analysis of glutathione conjugates
-
Baillie, T. A., and Davis, M. R. (1993) Mass spectrometry in the analysis of glutathione conjugates. Biol. Mass Spectrom. 22, 319-325.
-
(1993)
Biol. Mass Spectrom
, vol.22
, pp. 319-325
-
-
Baillie, T.A.1
Davis, M.R.2
-
10
-
-
17644404394
-
Negative ion tandem mass spectrometry for the detection of glutathione conjugates
-
Dieckhaus, C. M., Fernandez-Metzler, C. L., King, R., Krolikowski, P. H., and Baillie, T. A. (2005) Negative ion tandem mass spectrometry for the detection of glutathione conjugates. Chem. Res. Toxicol. 18, 630-638.
-
(2005)
Chem. Res. Toxicol
, vol.18
, pp. 630-638
-
-
Dieckhaus, C.M.1
Fernandez-Metzler, C.L.2
King, R.3
Krolikowski, P.H.4
Baillie, T.A.5
-
11
-
-
41149180635
-
High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry
-
Wen, B., Ma, L., Nelson, S. D., and Zhu, M. (2008) High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry. Anal. Chem. 80, 1788-1799.
-
(2008)
Anal. Chem
, vol.80
, pp. 1788-1799
-
-
Wen, B.1
Ma, L.2
Nelson, S.D.3
Zhu, M.4
-
12
-
-
0037435030
-
Mass spectrometry-based proteomics
-
Aebersold, R., and Mann, M. (2003) Mass spectrometry-based proteomics. Nature 422, 198-207.
-
(2003)
Nature
, vol.422
, pp. 198-207
-
-
Aebersold, R.1
Mann, M.2
-
14
-
-
4444335470
-
The ABC's (and XYZ's) of peptide sequencing
-
Steen, H., and Mann, M. (2004) The ABC's (and XYZ's) of peptide sequencing. Nat. Rev. Mol. Cell Biol. 5, 699-711.
-
(2004)
Nat. Rev. Mol. Cell Biol
, vol.5
, pp. 699-711
-
-
Steen, H.1
Mann, M.2
-
15
-
-
38949089246
-
Protein damage by reactive electrophiles: Targets and consequences
-
Liebler, D. C. (2008) Protein damage by reactive electrophiles: targets and consequences. Chem. Res. Toxicol. 21, 117-128.
-
(2008)
Chem. Res. Toxicol
, vol.21
, pp. 117-128
-
-
Liebler, D.C.1
-
16
-
-
0242412200
-
Separation and detection methods for covalent drugprotein adducts
-
Zhou, S. (2003) Separation and detection methods for covalent drugprotein adducts. J. Chromatogr. B 797, 63-90.
-
(2003)
J. Chromatogr. B
, vol.797
, pp. 63-90
-
-
Zhou, S.1
-
17
-
-
0032504193
-
Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry
-
Qiu, Y., Benet, L. Z., and Burlingame, A. L. (1998) Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J. Biol. Chem. 273, 17940-17953.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 17940-17953
-
-
Qiu, Y.1
Benet, L.Z.2
Burlingame, A.L.3
-
18
-
-
0029862643
-
Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital
-
He, K., Falick, A. M., Chen, B., Nilsson, F., and Correia, M. A. (1996) Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital. Chem. Res. Toxicol. 9, 614-622.
-
(1996)
Chem. Res. Toxicol
, vol.9
, pp. 614-622
-
-
He, K.1
Falick, A.M.2
Chen, B.3
Nilsson, F.4
Correia, M.A.5
-
19
-
-
0033596707
-
Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9
-
Koenigs, L. L., Peter, R. M., Hunter, A. P., Haining, R. L., Rettie, A. E., Friedberg, T., Pritchard, M. P., Shou, M., Rushmore, T. H., and Trager, W. F. (1999) Electrospray ionization mass spectrometric analysis of intact cytochrome P450: Identification of tienilic acid adducts to P450 2C9. Biochemistry 38, 2312-2319.
-
(1999)
Biochemistry
, vol.38
, pp. 2312-2319
-
-
Koenigs, L.L.1
Peter, R.M.2
Hunter, A.P.3
Haining, R.L.4
Rettie, A.E.5
Friedberg, T.6
Pritchard, M.P.7
Shou, M.8
Rushmore, T.H.9
Trager, W.F.10
-
20
-
-
0034681931
-
Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394
-
Lightning, L. K., Jones, J. P., Friedberg, T., Pritchard, M. P., Shou, M., Rushmore, T. H., and Trager, W. F. (2000) Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394. Biochemistry 39, 4276-4287.
-
(2000)
Biochemistry
, vol.39
, pp. 4276-4287
-
-
Lightning, L.K.1
Jones, J.P.2
Friedberg, T.3
Pritchard, M.P.4
Shou, M.5
Rushmore, T.H.6
Trager, W.F.7
-
21
-
-
33644536707
-
Identification of 17-R-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6
-
Kent, U. M., Lin, H. L., Mills, D. E., Regal, K. A., and Hollenberg, P. F. (2006) Identification of 17-R-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6. Chem. Res. Toxicol. 19, 279-287.
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 279-287
-
-
Kent, U.M.1
Lin, H.L.2
Mills, D.E.3
Regal, K.A.4
Hollenberg, P.F.5
-
22
-
-
34447133553
-
Time-dependent inactivation of P450 3A4 by raloxifene: Identification of Cys239 as the site of apoprotein alkylation
-
Baer, B. R., Wienkers, L. C., and Rock, D. A. (2007) Time-dependent inactivation of P450 3A4 by raloxifene: Identification of Cys239 as the site of apoprotein alkylation. Chem. Res. Toxicol. 20, 954-964.
-
(2007)
Chem. Res. Toxicol
, vol.20
, pp. 954-964
-
-
Baer, B.R.1
Wienkers, L.C.2
Rock, D.A.3
-
23
-
-
35848962726
-
Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry
-
Yukinaga, H., Takami, T., Shioyama, S. H., Tozuka, Z., Masumoto, H., Okazaki, O., and Sudo, K. (2007) Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry. Chem. Res. Toxicol. 20, 1373-1378.
-
(2007)
Chem. Res. Toxicol
, vol.20
, pp. 1373-1378
-
-
Yukinaga, H.1
Takami, T.2
Shioyama, S.H.3
Tozuka, Z.4
Masumoto, H.5
Okazaki, O.6
Sudo, K.7
-
24
-
-
55949124190
-
Modification of serine 360 by a reactive intermediate of 17-α- ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6
-
Kent, U. M., Sridar, C., Spahlinger, G., and Hollenberg, P. F. (2008) Modification of serine 360 by a reactive intermediate of 17-α- ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6. Chem. Res. Toxicol. 21, 1956-1963.
-
(2008)
Chem. Res. Toxicol
, vol.21
, pp. 1956-1963
-
-
Kent, U.M.1
Sridar, C.2
Spahlinger, G.3
Hollenberg, P.F.4
-
25
-
-
34447127578
-
Protein targets of reactive electrophiles in human liver microsomes
-
Shin, N. Y., Liu, Q., Stamer, S. L., and Liebler, D. C. (2007) Protein targets of reactive electrophiles in human liver microsomes. Chem. Res. Toxicol. 20, 859-867.
-
(2007)
Chem. Res. Toxicol
, vol.20
, pp. 859-867
-
-
Shin, N.Y.1
Liu, Q.2
Stamer, S.L.3
Liebler, D.C.4
-
26
-
-
34548183872
-
Protocol for micropurification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
-
Rappsilber, J., Mann, M., and Ishihama, Y. (2007) Protocol for micropurification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat. Protoc. 2, 1896-1906.
-
(2007)
Nat. Protoc
, vol.2
, pp. 1896-1906
-
-
Rappsilber, J.1
Mann, M.2
Ishihama, Y.3
-
27
-
-
29244448703
-
Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
-
Olsen, J. V., de Godoy, L. M., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S., and Mann, M. (2005) Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol. Cell. Proteomics 4, 2010-2021.
-
(2005)
Mol. Cell. Proteomics
, vol.4
, pp. 2010-2021
-
-
Olsen, J.V.1
de Godoy, L.M.2
Li, G.3
Macek, B.4
Mortensen, P.5
Pesch, R.6
Makarov, A.7
Lange, O.8
Horning, S.9
Mann, M.10
-
28
-
-
34548336772
-
Higher-energy C-trap dissociation for peptide modification analysis
-
Olsen, J. V., Macek, B., Lange, O., Makarov, A., Horning, S., and Mann, M. (2007) Higher-energy C-trap dissociation for peptide modification analysis. Nat. Methods 4, 709-712.
-
(2007)
Nat. Methods
, vol.4
, pp. 709-712
-
-
Olsen, J.V.1
Macek, B.2
Lange, O.3
Makarov, A.4
Horning, S.5
Mann, M.6
-
29
-
-
0034201441
-
EMBOSS: The european molecular biology open software suite
-
Rice, P., Longden, I., and Bleasby, A. (2000) EMBOSS: The european molecular biology open software suite. Trends Genet. 16, 276-277.
-
(2000)
Trends Genet
, vol.16
, pp. 276-277
-
-
Rice, P.1
Longden, I.2
Bleasby, A.3
-
30
-
-
67649971324
-
-
Fontana, E. , Bona, V., Hartung, T., Fowler, S., Norcross, R., Riemer, C., and Poli, S. M. In A New in Vitro Approach to Detect Cytochrome P450 Time Dependent Inhibition in Early Drug Discovery: A Case Study, Abstracts of the 2004 EUFEPS Meeting, Brussels, Belgium, October 17-20, 2004.
-
Fontana, E. , Bona, V., Hartung, T., Fowler, S., Norcross, R., Riemer, C., and Poli, S. M. In A New in Vitro Approach to Detect Cytochrome P450 Time Dependent Inhibition in Early Drug Discovery: A Case Study, Abstracts of the 2004 EUFEPS Meeting, Brussels, Belgium, October 17-20, 2004.
-
-
-
-
31
-
-
24944510505
-
Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity
-
Fontana, E., Dansette, P. M., and Poli, S. M. (2005) Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity. Curr. Drug Metab. 6, 413-454.
-
(2005)
Curr. Drug Metab
, vol.6
, pp. 413-454
-
-
Fontana, E.1
Dansette, P.M.2
Poli, S.M.3
-
32
-
-
0021235725
-
Reactive metabolites from the bioactivation of toxic methylfurans
-
Ravindranath, V., Burka, L. T., and Boyd, M. R. (1984) Reactive metabolites from the bioactivation of toxic methylfurans. Science 224, 884-886.
-
(1984)
Science
, vol.224
, pp. 884-886
-
-
Ravindranath, V.1
Burka, L.T.2
Boyd, M.R.3
-
33
-
-
0026510560
-
Reactive intermediates in the oxidation of menthofuran by cytochromes P-450
-
Thomassen, D., Knebel, N., Slattery, J. T., McClanahan, R. H., and Nelson, S. D. (1992) Reactive intermediates in the oxidation of menthofuran by cytochromes P-450. Chem. Res. Toxicol. 5, 123-130.
-
(1992)
Chem. Res. Toxicol
, vol.5
, pp. 123-130
-
-
Thomassen, D.1
Knebel, N.2
Slattery, J.T.3
McClanahan, R.H.4
Nelson, S.D.5
-
34
-
-
0037027003
-
Protein adducts: Quantitative and qualitative aspects of their formation, analysis and applications
-
Törnqvist, M., Fred, C., Haglund, J., Helleberg, H., Paulsson, B., and Rydberg, P. (2002) Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J. Chromatogr. B 778, 279-308.
-
(2002)
J. Chromatogr. B
, vol.778
, pp. 279-308
-
-
Törnqvist, M.1
Fred, C.2
Haglund, J.3
Helleberg, H.4
Paulsson, B.5
Rydberg, P.6
-
35
-
-
0035987523
-
Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: Cytochromes P450 and other membrane proteins
-
Galeva, N., and Altermann, M. (2002) Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: cytochromes P450 and other membrane proteins. Proteomics 2, 713-722.
-
(2002)
Proteomics
, vol.2
, pp. 713-722
-
-
Galeva, N.1
Altermann, M.2
-
36
-
-
0035106351
-
Largescale analysis of the yeast proteome by multidimensional protein identification technology
-
Washburn, M. P., Wolters, D., and Yates, J. R., 3rd (2001) Largescale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242-247.
-
(2001)
Nat. Biotechnol
, vol.19
, pp. 242-247
-
-
Washburn, M.P.1
Wolters, D.2
Yates 3rd, J.R.3
-
37
-
-
0037277179
-
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: The yeast proteome
-
Peng, J., Elias, J. E., Thoreen, C. C., Licklider, L. J., and Gygi, S. P. (2003) Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: The yeast proteome. J. Proteome Res. 2, 43-50.
-
(2003)
J. Proteome Res
, vol.2
, pp. 43-50
-
-
Peng, J.1
Elias, J.E.2
Thoreen, C.C.3
Licklider, L.J.4
Gygi, S.P.5
-
38
-
-
33749009806
-
Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry
-
Ma, S., and Subramanian, R. (2006) Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry. J. Mass Spectrom. 41, 1121-1139.
-
(2006)
J. Mass Spectrom
, vol.41
, pp. 1121-1139
-
-
Ma, S.1
Subramanian, R.2
-
39
-
-
1842536853
-
A proteomic approach to the identification of cytochrome P450 isoforms in male and female rat liver by nanoscale liquid chromatography-electrospray ionizationtandem mass spectrometry
-
Nisar, S., Lane, C. S., Wilderspin, A. F., Welham, K. J., Griffiths, W. J., and Patterson, L. H. (2004) A proteomic approach to the identification of cytochrome P450 isoforms in male and female rat liver by nanoscale liquid chromatography-electrospray ionizationtandem mass spectrometry. Drug Metab. Dispos. 32, 382-386.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 382-386
-
-
Nisar, S.1
Lane, C.S.2
Wilderspin, A.F.3
Welham, K.J.4
Griffiths, W.J.5
Patterson, L.H.6
-
40
-
-
34248639064
-
Proteomic analysis of cytochromes P450: A mass spectrometry approach
-
Wang, Y., Al-Gazzar, A., Seibert, C., Sharif, A., Lane, C., and Griffiths, W. J. (2006) Proteomic analysis of cytochromes P450: a mass spectrometry approach. Biochem. Soc. Trans. 34, 1246-1251.
-
(2006)
Biochem. Soc. Trans
, vol.34
, pp. 1246-1251
-
-
Wang, Y.1
Al-Gazzar, A.2
Seibert, C.3
Sharif, A.4
Lane, C.5
Griffiths, W.J.6
-
41
-
-
33947658874
-
The reactive metabolite target protein database (TPDB)-A web-accessible resource
-
Hanzlik, R. P., Koen, Y. M., Theertham, B., Dong, Y., and Fang, J. (2007) The reactive metabolite target protein database (TPDB)-A web-accessible resource. BMC Bioinf. 8, 95.
-
(2007)
BMC Bioinf
, vol.8
, pp. 95
-
-
Hanzlik, R.P.1
Koen, Y.M.2
Theertham, B.3
Dong, Y.4
Fang, J.5
-
42
-
-
0030992926
-
Cytochrome P4502C11 is a target of diclofenac covalent binding in rats
-
Shen, S., Hargus, S. J., Martin, B. M., and Pohl, L. R. (1997) Cytochrome P4502C11 is a target of diclofenac covalent binding in rats. Chem. Res. Toxicol. 10, 420-423.
-
(1997)
Chem. Res. Toxicol
, vol.10
, pp. 420-423
-
-
Shen, S.1
Hargus, S.J.2
Martin, B.M.3
Pohl, L.R.4
-
43
-
-
0034642187
-
Reactivity of cysteine-49 and its influence on the activation of microsomal glutathione transferase 1: Evidence for subunit interaction
-
Svensson, R., Rinaldi, R., Swedmark, S., and Morgenstern, R. (2000) Reactivity of cysteine-49 and its influence on the activation of microsomal glutathione transferase 1: Evidence for subunit interaction. Biochemistry 39, 15144-15149.
-
(2000)
Biochemistry
, vol.39
, pp. 15144-15149
-
-
Svensson, R.1
Rinaldi, R.2
Swedmark, S.3
Morgenstern, R.4
-
44
-
-
4444316044
-
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1
-
Busenlehner, L. S., Codreanu, S. G., Holm, P. J., Bhakat, P., Hebert, H., Morgenstern, R., and Armstrong, R. N. (2004) Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1. Biochemistry 43, 11145-11152.
-
(2004)
Biochemistry
, vol.43
, pp. 11145-11152
-
-
Busenlehner, L.S.1
Codreanu, S.G.2
Holm, P.J.3
Bhakat, P.4
Hebert, H.5
Morgenstern, R.6
Armstrong, R.N.7
-
45
-
-
0036127307
-
Biotransformation reactions of five-membered aromatic heterocyclic rings
-
Dalvie, D. K., Kalgutkar, A. S., Khojasteh-Bakht, S. C., Obach, R. S., and O'Donnell, J. P. (2002) Biotransformation reactions of five-membered aromatic heterocyclic rings. Chem. Res. Toxicol. 15, 269-299.
-
(2002)
Chem. Res. Toxicol
, vol.15
, pp. 269-299
-
-
Dalvie, D.K.1
Kalgutkar, A.S.2
Khojasteh-Bakht, S.C.3
Obach, R.S.4
O'Donnell, J.P.5
-
46
-
-
33748656068
-
Thiazolidinedione bioactivation: A comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry
-
Alvarez-Sanchez, R., Montavon, F., Hartung, T., and Pähler, A. (2006) Thiazolidinedione bioactivation: A comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry. Chem. Res. Toxicol. 19, 1106-1116.
-
(2006)
Chem. Res. Toxicol
, vol.19
, pp. 1106-1116
-
-
Alvarez-Sanchez, R.1
Montavon, F.2
Hartung, T.3
Pähler, A.4
-
47
-
-
20844454730
-
Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4
-
Kalgutkar, A. S., Vaz, A. D., Lame, M. E., Henne, K. R., Soglia, J., Zhao, S. X., Abramov, Y. A., Lombardo, F., Collin, C., Hendsch, Z. S., and Hop, C. E. (2005) Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4. Drug Metab. Dispos. 33, 243-253.
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 243-253
-
-
Kalgutkar, A.S.1
Vaz, A.D.2
Lame, M.E.3
Henne, K.R.4
Soglia, J.5
Zhao, S.X.6
Abramov, Y.A.7
Lombardo, F.8
Collin, C.9
Hendsch, Z.S.10
Hop, C.E.11
-
48
-
-
20644438440
-
Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinoneimine and epoxide intermediates in human liver microsomes and recombinant P4503A4
-
Kalgutkar, A. S., Henne, K. R., Lame, M. E., Vaz, A. D., Collin, C., Soglia, J. R., Zhao, S. X., and Hop, C. E. (2005) Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinoneimine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem.-Biol. Interact. 155, 10-20.
-
(2005)
Chem.-Biol. Interact
, vol.155
, pp. 10-20
-
-
Kalgutkar, A.S.1
Henne, K.R.2
Lame, M.E.3
Vaz, A.D.4
Collin, C.5
Soglia, J.R.6
Zhao, S.X.7
Hop, C.E.8
-
49
-
-
67649949488
-
. Drug-induced hepatotoxicity: Learning from recent cases of drug attrition
-
Fishbein, J. C, Ed, pp, Elsevier, Amsterdam
-
Pähler, A., and Funk, C. (2008) Chapter 2. Drug-induced hepatotoxicity: Learning from recent cases of drug attrition. In Advances in Molecular Toxicology (Fishbein, J. C., Ed.) pp 25-56, Elsevier, Amsterdam.
-
(2008)
Advances in Molecular Toxicology
, pp. 25-56
-
-
Pähler, A.1
Funk, C.2
-
50
-
-
53549100467
-
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose
-
Obach, R. S., Kalgutkar, A. S., Soglia, J. R., and Zhao, S. X. (2008) Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem. Res. Toxicol. 21, 1814-1822.
-
(2008)
Chem. Res. Toxicol
, vol.21
, pp. 1814-1822
-
-
Obach, R.S.1
Kalgutkar, A.S.2
Soglia, J.R.3
Zhao, S.X.4
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