Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. NMR studies of the covalent binding of the 13C-labeled skin sensitizers 2-[13C]- and 3-[13C]hex-1-ene- and 3-[13C]hexanes-1,3-sultones to human serum albumin

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 118-126

  Meschkat, Emmanuel ^a   Barratt, Martin D ^b,c   Lepoittevin, Jean Pierre ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b UNILEVER RESEARCH   (United Kingdom)

^c Marlin Consultancy   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HEX 1 ENE 1,3 SULTONE; 3 HEX 1 ENE 1,3 SULTONE; 3 HEXANE 1,3 SULTONE; CARBON 13; HAPTEN; HUMAN SERUM ALBUMIN; SULTONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; COVALENT BOND; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SKIN SENSITIZATION;

ACETYLATION; BINDING, COMPETITIVE; BUTYLAMINES; CARBON ISOTOPES; HAPTENS; HYDROLYSIS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHALENESULFONATES; PHENOLS; PROTEIN BINDING; SERUM ALBUMIN;

EID: 0035156321     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000226f     Document Type: Article

References (5)

1. Rycroft, R. J. G., Menné, T., and Frosch, P. J., Eds. (1995) Textbook of contact dermatitis, Springer-Verlag,.
2. Lepoittevin, J. P., Basketter, D. A., Goossens, A., and Karlberg, A. T., Eds. (1997) Allergic contact dermatitis: the molecular basis, Springer, Berlin.
3. 13C-labeled skin sensitizers hex-1-ene- and hexane-1,3-sultones. Chem. Res. Toxicol. 14, 110-117.
4. Pearson, R. G. (1963) Hard and soft acids and bases. J. Am. Chem. Soc. 85, 3533-3539.
5. Kurono, Y., Maki, T., Yotsuyanagi, T., and Ikeda, K. (1979) Esterase-like activity of human serum albumin: Structure-activity relationships for the reactions with phenyl acetates and p-nitrophenyl esters. Chem. Pharm. Bull. 27, 2781-2786.