An analysis of p16 protein expression in sporadic malignant melanoma

Melanoma Research

Volumn 8, Issue 3, 1998, Pages 267-272

  Grover, R ^a   Chana, J S ^a   Wilson, G D ^a   Richman, P I ^a   Sanders, R ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

CDKN2; Flow cytometry; Malignant melanoma; Metastasis; Naevus; P16

Indexed keywords

PROTEIN P16;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; FEMALE; FLOW CYTOMETRY; GENE REPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MELANOCYTIC NEVUS; MELANOMA; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN METASTASIS; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNE SERA; MALE; MELANOMA; MIDDLE AGED; NEVUS, PIGMENTED; NUCLEAR PROTEINS; SKIN NEOPLASMS; SURVIVAL RATE; TISSUE DISTRIBUTION;

EID: 0031809584     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-199806000-00010     Document Type: Article

References (21)

1. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368(6473): 753-756.
2. Kamb A, Gruis NA, Weaver Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264(5157): 436-440.
3. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366(6456): 704-707.
4. Guan KL, Jenkins CW, Li Y, et al. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 1994; 8(24): 2939-2952.
5. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323-330.
6. Liu Q, Neuhausen S, McClure M, et al. CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines. Oncogene 1995; 10(6): 1061-1067.
7. Cairns P, Mao L, Merlo A, et al. Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science 1994; 265(5170): 415-417(letter).
8. Marx J. A challenge to p16 gene as a major tumor suppressor. Science 1994; 264(5167): 1846.
9. Spruck CH 3rd, Gonzalez Zulueta M, Shibata A, et al. p16 gene in uncultured tumours. Nature 1994; 370(6486): 183-184(letter).
10. INK4b genes, as well as neighbouring 9p21 markers, in sporadic melanoma. Cancer Res 1996; 56: 5023-5032.
11. Merlo A, Herman JG, Mao L, et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1(7): 686-692.
12. Gonzalez Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995; 55(20): 4531-4535.
13. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333-1335.
14. Reed JA, Loganzo F Jr, Shea CR, et al. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res 1995; 55(13): 2713-2718.
15. Watson JV. Introduction to Flow Cytometry. Cambridge: Cambridge University Press, 1991: 271.
16. Kaplan EL, Meier P. Nonparametric estimation of incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
17. Maelandsmo GM, Florenes VA, Hovig E, et al. Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br J Cancer 1996; 73(8): 909-916.
18. Thompson FH, Emerson J, Olson S, et al. Cytogenetics of 158 patients with regional or disseminated melanoma. Cancer Genet Cytogenet 1995; 83: 93-104.
19. Healy E, Belgaid CE, Takata M, et al. Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res 1996; 56: 589-593.
20. Jin X, Nguyen D, Zhang WW, Kyritsis AP, Roth JA. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res 1995; 55(15): 3250-3253.
21. Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJ. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res 1995; 55(6): 1351-1354.