메뉴 건너뛰기




Volumn 62, Issue 3, 2007, Pages 246-255

Stress chaperones, mortalin, and Pex19p mediate 5-Aza-2′ deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CHAPERONE; MORTALIN; PROTEIN P16INK4A; PROTEIN P53; PROTEIN PEX19P; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; AZACITIDINE; BIOLOGICAL MARKER; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; LIPOPROTEIN; MEMBRANE PROTEIN; PEX19 PROTEIN, HUMAN; TUMOR MARKER;

EID: 34248568103     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/62.3.246     Document Type: Article
Times cited : (26)

References (76)
  • 1
    • 12344330351 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
    • Sakajiri S, Kumagai T, Kawamata N, Saitoh T, Said JW, Koeffler HP. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp Hematol 2005;33:53-61.
    • (2005) Exp Hematol , vol.33 , pp. 53-61
    • Sakajiri, S.1    Kumagai, T.2    Kawamata, N.3    Saitoh, T.4    Said, J.W.5    Koeffler, H.P.6
  • 2
    • 4344633280 scopus 로고    scopus 로고
    • CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer
    • Enokida H, Shiina H, Igawa M, et al. CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer. Cancer Res. 2004;64:5956-5962.
    • (2004) Cancer Res , vol.64 , pp. 5956-5962
    • Enokida, H.1    Shiina, H.2    Igawa, M.3
  • 3
    • 0037431507 scopus 로고    scopus 로고
    • Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma
    • Huang Y, de la Chapelle A, Pellegata NS. Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. Int J Cancer. 2003;104:735-744.
    • (2003) Int J Cancer , vol.104 , pp. 735-744
    • Huang, Y.1    de la Chapelle, A.2    Pellegata, N.S.3
  • 4
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood. 2004;103:1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3
  • 6
    • 0033179375 scopus 로고    scopus 로고
    • Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
    • Melki JR, Vincent PC, Clark SJ. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res. 1999;59: 3730-3740.
    • (1999) Cancer Res , vol.59 , pp. 3730-3740
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 7
    • 1042263110 scopus 로고    scopus 로고
    • Promoter methylation of cyclin D2 gene in gastric carcinoma
    • Oshimo Y, Nakayama H, Ito R, et al. Promoter methylation of cyclin D2 gene in gastric carcinoma. Int J Oncol. 2003;23:1663-1670.
    • (2003) Int J Oncol , vol.23 , pp. 1663-1670
    • Oshimo, Y.1    Nakayama, H.2    Ito, R.3
  • 8
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria JC, Lee HY, Lee JI, et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res. 2002;8:1178-1184.
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-1184
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3
  • 9
    • 9144258612 scopus 로고    scopus 로고
    • Expression and regulation of tumor suppressor gene maspin in human bladder cancer
    • Sugimoto S, Maass N, Takimoto Y, et al. Expression and regulation of tumor suppressor gene maspin in human bladder cancer. Cancer Lett. 2004;203:209-215.
    • (2004) Cancer Lett , vol.203 , pp. 209-215
    • Sugimoto, S.1    Maass, N.2    Takimoto, Y.3
  • 10
    • 0035392955 scopus 로고    scopus 로고
    • Promoter hypermethylation: A common cause of reduced p16(INK4a) expression in uveal melanoma
    • van der Velden PA, Metzelaar-Blok JA, Bergman W, et al. Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma. Cancer Res. 2001;61:5303-5306.
    • (2001) Cancer Res , vol.61 , pp. 5303-5306
    • van der Velden, P.A.1    Metzelaar-Blok, J.A.2    Bergman, W.3
  • 11
    • 0142059070 scopus 로고    scopus 로고
    • Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers
    • Virmani A, Rathi A, Heda S, et al. Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers. Int J Cancer. 2003;107:341-345.
    • (2003) Int J Cancer , vol.107 , pp. 341-345
    • Virmani, A.1    Rathi, A.2    Heda, S.3
  • 12
    • 0037431542 scopus 로고    scopus 로고
    • Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers
    • Yu MY, Tong JH, Chan PK, et al. Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers. Int J Cancer. 2003;105:204-209.
    • (2003) Int J Cancer , vol.105 , pp. 204-209
    • Yu, M.Y.1    Tong, J.H.2    Chan, P.K.3
  • 13
    • 0035324425 scopus 로고    scopus 로고
    • 5′ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer
    • Zochbauer-Muller S, Fong KM, Maitra A, et al. 5′ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res. 2001;61:3581-3585.
    • (2001) Cancer Res , vol.61 , pp. 3581-3585
    • Zochbauer-Muller, S.1    Fong, K.M.2    Maitra, A.3
  • 14
    • 16544395591 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004;22:4632-4642.
    • (2004) J Clin Oncol , vol.22 , pp. 4632-4642
    • Das, P.M.1    Singal, R.2
  • 15
    • 0035989528 scopus 로고    scopus 로고
    • DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
    • Hiltunen MO, Turunen MP, Hakkinen TP, et al. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med. 2002;7:5-11.
    • (2002) Vasc Med , vol.7 , pp. 5-11
    • Hiltunen, M.O.1    Turunen, M.P.2    Hakkinen, T.P.3
  • 16
    • 0035872493 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in hepatocellular carcinogenesis
    • Lin CH, Hsieh SY, Sheen IS, et al. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res. 2001;61:4238-4243.
    • (2001) Cancer Res , vol.61 , pp. 4238-4243
    • Lin, C.H.1    Hsieh, S.Y.2    Sheen, I.S.3
  • 17
    • 0141839825 scopus 로고    scopus 로고
    • Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts
    • Casillas MA Jr, Lopatina N, Andrews LG, Tollefsbol TO. Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol Cell Biochem. 2003;252:33-43.
    • (2003) Mol Cell Biochem , vol.252 , pp. 33-43
    • Casillas Jr, M.A.1    Lopatina, N.2    Andrews, L.G.3    Tollefsbol, T.O.4
  • 18
    • 0028080422 scopus 로고
    • Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts
    • Vertino PM, Issa JP, Pereira-Smith OM, Baylin SB. Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts. Cell Growth Differ. 1994;5:1395-1402.
    • (1994) Cell Growth Differ , vol.5 , pp. 1395-1402
    • Vertino, P.M.1    Issa, J.P.2    Pereira-Smith, O.M.3    Baylin, S.B.4
  • 19
    • 0033563083 scopus 로고    scopus 로고
    • CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
    • Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV, Laird PW. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 1999;59:2302-2306.
    • (1999) Cancer Res , vol.59 , pp. 2302-2306
    • Eads, C.A.1    Danenberg, K.D.2    Kawakami, K.3    Saltz, L.B.4    Danenberg, P.V.5    Laird, P.W.6
  • 20
    • 0141995080 scopus 로고    scopus 로고
    • Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas
    • Girault I, Tozlu S, Lidereau R, Bieche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res. 2003;9:4415-4422.
    • (2003) Clin Cancer Res , vol.9 , pp. 4415-4422
    • Girault, I.1    Tozlu, S.2    Lidereau, R.3    Bieche, I.4
  • 22
    • 0031907905 scopus 로고    scopus 로고
    • Increased DNA methyltransferase expression in leukaemia
    • Melki JR, Warnecke P, Vincent PC, Clark SJ. Increased DNA methyltransferase expression in leukaemia. Leukemia. 1998;12:311-316.
    • (1998) Leukemia , vol.12 , pp. 311-316
    • Melki, J.R.1    Warnecke, P.2    Vincent, P.C.3    Clark, S.J.4
  • 23
    • 0242523715 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder
    • Nakagawa T, Kanai Y, Saito Y, Kitamura T, Kakizoe T, Hirohashi S. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. J Urol. 2003;170:2463-2466.
    • (2003) J Urol , vol.170 , pp. 2463-2466
    • Nakagawa, T.1    Kanai, Y.2    Saito, Y.3    Kitamura, T.4    Kakizoe, T.5    Hirohashi, S.6
  • 24
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology. 2001;33:561-568.
    • (2001) Hepatology , vol.33 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 25
    • 0036735345 scopus 로고    scopus 로고
    • A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer
    • Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res. 2002;62:4992-4995.
    • (2002) Cancer Res , vol.62 , pp. 4992-4995
    • Shen, H.1    Wang, L.2    Spitz, M.R.3    Hong, W.K.4    Mao, L.5    Wei, Q.6
  • 26
    • 0023125009 scopus 로고
    • The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation
    • Fairweather DS, Fox M, Margison GP. The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation. Exp Cell Res. 1987;168:153-159.
    • (1987) Exp Cell Res , vol.168 , pp. 153-159
    • Fairweather, D.S.1    Fox, M.2    Margison, G.P.3
  • 27
    • 0023279926 scopus 로고
    • The inheritance of epigenetic defects
    • Holliday R. The inheritance of epigenetic defects. Science. 1987;238:163-170.
    • (1987) Science , vol.238 , pp. 163-170
    • Holliday, R.1
  • 28
    • 0038677615 scopus 로고    scopus 로고
    • Epigenetic silencing of multiple interferon pathway genes after cellular immortalization
    • Kulaeva OI, Draghici S, Tang L, Kraniak JM, Land SJ, Tainsky MA. Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene. 2003;22:4118-1127.
    • (2003) Oncogene , vol.22 , pp. 4118-1127
    • Kulaeva, O.I.1    Draghici, S.2    Tang, L.3    Kraniak, J.M.4    Land, S.J.5    Tainsky, M.A.6
  • 29
    • 0034634759 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines
    • Suh SI, Pyun HY, Cho JW, et al. 5-Aza-2′-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. Cancer Lett. 2000;160:81-88.
    • (2000) Cancer Lett , vol.160 , pp. 81-88
    • Suh, S.I.1    Pyun, H.Y.2    Cho, J.W.3
  • 30
    • 0031992493 scopus 로고    scopus 로고
    • Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts
    • Vogt M, Haggblom C, Yeargin J, Christiansen-Weber T, Haas M. Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts. Cell Growth Differ. 1998;9:139-146.
    • (1998) Cell Growth Differ , vol.9 , pp. 139-146
    • Vogt, M.1    Haggblom, C.2    Yeargin, J.3    Christiansen-Weber, T.4    Haas, M.5
  • 31
    • 0031018480 scopus 로고    scopus 로고
    • Frequent aberrant methylation of p16INK4a in primary rat lung tumors
    • Swafford DS, Middleton SK, Palmisano WA, et al. Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol. 1997;17:1366-1374.
    • (1997) Mol Cell Biol , vol.17 , pp. 1366-1374
    • Swafford, D.S.1    Middleton, S.K.2    Palmisano, W.A.3
  • 32
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
    • Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 1996;16:859-867.
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Stone, S.5    Peters, G.6
  • 33
    • 0032528623 scopus 로고    scopus 로고
    • Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
    • Huschtscha LI, Noble IR, Neumann AA, et al. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res. 1998;58:3508-3512.
    • (1998) Cancer Res , vol.58 , pp. 3508-3512
    • Huschtscha, L.I.1    Noble, I.R.2    Neumann, A.A.3
  • 34
    • 0030612753 scopus 로고    scopus 로고
    • Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status
    • Palmero I, McConnell B, Parry D, et al. Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Oncogene. 1997;15:495-503.
    • (1997) Oncogene , vol.15 , pp. 495-503
    • Palmero, I.1    McConnell, B.2    Parry, D.3
  • 35
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 36
    • 0030876483 scopus 로고    scopus 로고
    • Induction of senescence in human malignant glioma cells by p16INK4A
    • Uhrbom L, Nister M, Westermark B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene. 1997;15:505-514.
    • (1997) Oncogene , vol.15 , pp. 505-514
    • Uhrbom, L.1    Nister, M.2    Westermark, B.3
  • 37
    • 0035930621 scopus 로고    scopus 로고
    • Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression
    • Duan J, Zhang Z, Tong T. Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression. J Biol Chem. 2001;276:48325-48331.
    • (2001) J Biol Chem , vol.276 , pp. 48325-48331
    • Duan, J.1    Zhang, Z.2    Tong, T.3
  • 38
    • 0029890863 scopus 로고    scopus 로고
    • Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
    • Reznikoff CA, Yeager TR, Belair CD, Savelieva E, Puthenveettil JA, Stadler WM. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res. 1996;56:2886-2890.
    • (1996) Cancer Res , vol.56 , pp. 2886-2890
    • Reznikoff, C.A.1    Yeager, T.R.2    Belair, C.D.3    Savelieva, E.4    Puthenveettil, J.A.5    Stadler, W.M.6
  • 39
    • 0344990164 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion 5-aza-2′-deoxycytidine
    • Aparicio A, Eads CA, Leong LA, et al. Phase I trial of continuous infusion 5-aza-2′-deoxycytidine. Cancer Chemother Pharmacol. 2003;51:231-239.
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 231-239
    • Aparicio, A.1    Eads, C.A.2    Leong, L.A.3
  • 41
    • 0026452576 scopus 로고
    • Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma
    • Casper ES, Schwartz GK, Kelsen DP. Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma. Invest New Drugs. 1992;10:205-209.
    • (1992) Invest New Drugs , vol.10 , pp. 205-209
    • Casper, E.S.1    Schwartz, G.K.2    Kelsen, D.P.3
  • 42
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study
    • Kornblith AB, Herndon JE 2nd, Silverman LR, et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol. 2002;20:2441-2452.
    • (2002) J Clin Oncol , vol.20 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon 2nd, J.E.2    Silverman, L.R.3
  • 43
    • 0036794950 scopus 로고    scopus 로고
    • Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix
    • Pohlmann P, DiLeone LP, Cancella Al, et al. Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix. Am J Clin Oncol. 2002;25:496-501.
    • (2002) Am J Clin Oncol , vol.25 , pp. 496-501
    • Pohlmann, P.1    DiLeone, L.P.2    Cancella, A.3
  • 44
    • 0031945210 scopus 로고    scopus 로고
    • A phase II study of 5-aza-2′ deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
    • Thibault A, Figg WD, Bergan RC, et al. A phase II study of 5-aza-2′ deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori. 1998;84:87-89.
    • (1998) Tumori , vol.84 , pp. 87-89
    • Thibault, A.1    Figg, W.D.2    Bergan, R.C.3
  • 45
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A. 1994;91:11797-11801.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 46
    • 25444522227 scopus 로고    scopus 로고
    • Molecular chaperones in protein quality control
    • Lee S, Tsai FT. Molecular chaperones in protein quality control. J Biochem Mol Biol. 2005;38:259-265.
    • (2005) J Biochem Mol Biol , vol.38 , pp. 259-265
    • Lee, S.1    Tsai, F.T.2
  • 47
    • 10944269121 scopus 로고    scopus 로고
    • Modelling the actions of chaperones and their role in ageing
    • Proctor CJ, Soti C, Boys RJ, et al. Modelling the actions of chaperones and their role in ageing. Mech Ageing Dev. 2005;126:119-131.
    • (2005) Mech Ageing Dev , vol.126 , pp. 119-131
    • Proctor, C.J.1    Soti, C.2    Boys, R.J.3
  • 48
    • 25844466597 scopus 로고    scopus 로고
    • Heat shock response modulators as therapeutic tools for diseases of protein conformation
    • Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem. 2005;280:33097-33100.
    • (2005) J Biol Chem , vol.280 , pp. 33097-33100
    • Westerheide, S.D.1    Morimoto, R.I.2
  • 49
    • 0037184122 scopus 로고    scopus 로고
    • A major functional difference between the mouse and human ARF tumor suppressor proteins
    • Wadhwa R, Sugihara T, Hasan MK, Taira K, Reddel RR, Kaul SC. A major functional difference between the mouse and human ARF tumor suppressor proteins. J Biol Chem. 2002;277:36665-36670.
    • (2002) J Biol Chem , vol.277 , pp. 36665-36670
    • Wadhwa, R.1    Sugihara, T.2    Hasan, M.K.3    Taira, K.4    Reddel, R.R.5    Kaul, S.C.6
  • 50
    • 0042091934 scopus 로고    scopus 로고
    • Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes
    • 2003;4:595-601
    • Wadhwa R, Ando H, Kawasaki H, Taira K, Kaul SC. Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes. EMBO Rep. 2003;4:595-601.
    • EMBO Rep
    • Wadhwa, R.1    Ando, H.2    Kawasaki, H.3    Taira, K.4    Kaul, S.C.5
  • 51
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995;92:9363-9367.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 52
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • Campisi J. The biology of replicative senescence. Eur J Cancer. 1997;33:703-709.
    • (1997) Eur J Cancer , vol.33 , pp. 703-709
    • Campisi, J.1
  • 53
    • 0034575087 scopus 로고    scopus 로고
    • Senescence and immortalization of human cells
    • Duncan EL, Wadhwa R, Kaul SC. Senescence and immortalization of human cells. Biogerontology. 2000;1:103-121.
    • (2000) Biogerontology , vol.1 , pp. 103-121
    • Duncan, E.L.1    Wadhwa, R.2    Kaul, S.C.3
  • 54
    • 0022222407 scopus 로고
    • The cell biology of aging
    • Hayflick L. The cell biology of aging. Clin Geriatr Med. 1985;1:15-27.
    • (1985) Clin Geriatr Med , vol.1 , pp. 15-27
    • Hayflick, L.1
  • 55
    • 0029162202 scopus 로고
    • Life span prediction from the rate of age-related DNA demethylation in normal and cancer cell lines
    • Mazin AL. Life span prediction from the rate of age-related DNA demethylation in normal and cancer cell lines. Exp Gerontol. 1995;30:475-484.
    • (1995) Exp Gerontol , vol.30 , pp. 475-484
    • Mazin, A.L.1
  • 56
    • 0032585651 scopus 로고    scopus 로고
    • Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
    • Timmermann S, Hinds PW, Munger K. Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state. Oncogene. 1998;17:3445-3453.
    • (1998) Oncogene , vol.17 , pp. 3445-3453
    • Timmermann, S.1    Hinds, P.W.2    Munger, K.3
  • 57
    • 0037387730 scopus 로고    scopus 로고
    • Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb
    • Veitonmaki N, Fuxe J, Hultdin M, Roos G, Pettersson RF, Cao Y. Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb. FASEB J. 2003; 17:764-766,
    • (2003) FASEB J , vol.17 , pp. 764-766
    • Veitonmaki, N.1    Fuxe, J.2    Hultdin, M.3    Roos, G.4    Pettersson, R.F.5    Cao, Y.6
  • 58
    • 13644254746 scopus 로고    scopus 로고
    • Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells
    • Wadhwa R, Takano S, Taira K, Kaul SC. Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J Gene Med. 2004;6:439-444.
    • (2004) J Gene Med , vol.6 , pp. 439-444
    • Wadhwa, R.1    Takano, S.2    Taira, K.3    Kaul, S.C.4
  • 59
    • 11144349225 scopus 로고    scopus 로고
    • Mortalin is overexpressed by colorectal adenocarcinomas and correlates with poor survival
    • Dundas SR, Lawrie LC, Rooney PH, Murray GI. Mortalin is overexpressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol. 2005;205:74-81.
    • (2005) J Pathol , vol.205 , pp. 74-81
    • Dundas, S.R.1    Lawrie, L.C.2    Rooney, P.H.3    Murray, G.I.4
  • 61
    • 33646409045 scopus 로고    scopus 로고
    • Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis
    • Wadhwa R, Takano S, Kaur K, et al. Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer. 2006;118:2973-2980.
    • (2006) Int J Cancer , vol.118 , pp. 2973-2980
    • Wadhwa, R.1    Takano, S.2    Kaur, K.3
  • 62
    • 0027478676 scopus 로고
    • Induction of replicative senescence by 5-azacytidine: Fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells
    • Weller EM, Poot M, Hoehn H. Induction of replicative senescence by 5-azacytidine: fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells. Cell Prolif. 1993;26:45-54.
    • (1993) Cell Prolif , vol.26 , pp. 45-54
    • Weller, E.M.1    Poot, M.2    Hoehn, H.3
  • 63
    • 0027227379 scopus 로고
    • Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts
    • Wadhwa R, Kaul SC, Mitsui Y, Sugimoto Y. Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts. Exp Cell Res. 1993;207:442-448.
    • (1993) Exp Cell Res , vol.207 , pp. 442-448
    • Wadhwa, R.1    Kaul, S.C.2    Mitsui, Y.3    Sugimoto, Y.4
  • 64
    • 0028955637 scopus 로고
    • Correlation between complementation group for immortality and the cellular distribution of mortalin
    • Wadhwa R, Pereira-Smith OM, Reddel RR, Sugimoto Y, Mitsui Y, Kaul SC. Correlation between complementation group for immortality and the cellular distribution of mortalin. Exp Cell Res. 1995;216:101-106.
    • (1995) Exp Cell Res , vol.216 , pp. 101-106
    • Wadhwa, R.1    Pereira-Smith, O.M.2    Reddel, R.R.3    Sugimoto, Y.4    Mitsui, Y.5    Kaul, S.C.6
  • 65
    • 0345654336 scopus 로고    scopus 로고
    • Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes
    • Bertram MJ, Bérubé NG, Hang-Swanson X, et al. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol. 1999;19:1479-1485.
    • (1999) Mol Cell Biol , vol.19 , pp. 1479-1485
    • Bertram, M.J.1    Bérubé, N.G.2    Hang-Swanson, X.3
  • 66
    • 0033231407 scopus 로고    scopus 로고
    • Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line
    • Nakabayashi K, Ogino H, Michishita E, Satoh N, Ayusawa D. Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line. Exp Cell Res. 1999;252:376-382.
    • (1999) Exp Cell Res , vol.252 , pp. 376-382
    • Nakabayashi, K.1    Ogino, H.2    Michishita, E.3    Satoh, N.4    Ayusawa, D.5
  • 67
    • 0033381225 scopus 로고    scopus 로고
    • 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species
    • Michishita E, Nakabayashi K, Suzuki T, et al. 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species. J Biochem. 1999;126:1052-1059.
    • (1999) J Biochem , vol.126 , pp. 1052-1059
    • Michishita, E.1    Nakabayashi, K.2    Suzuki, T.3
  • 68
    • 0034671731 scopus 로고    scopus 로고
    • Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function
    • Wadhwa R, Sugihara T, Yoshida A, et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000;60:6818-6821.
    • (2000) Cancer Res , vol.60 , pp. 6818-6821
    • Wadhwa, R.1    Sugihara, T.2    Yoshida, A.3
  • 69
    • 0037349289 scopus 로고    scopus 로고
    • p53 has a direct apoptogenic role at the mitochondria
    • Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-590.
    • (2003) Mol Cell , vol.11 , pp. 577-590
    • Mihara, M.1    Erster, S.2    Zaika, A.3
  • 70
    • 0032491426 scopus 로고    scopus 로고
    • Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member
    • Wadhwa R, Takano S, Robert M, et al. Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem. 1998;273:29586-29591.
    • (1998) J Biol Chem , vol.273 , pp. 29586-29591
    • Wadhwa, R.1    Takano, S.2    Robert, M.3
  • 71
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR, Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res. 1994;211:90-98.
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 72
    • 4644250692 scopus 로고    scopus 로고
    • Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins
    • Shibata H, Kashiwayama Y, Imanaka T, Kato H. Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins. J Biol Chem. 2004; 279:38486-38494.
    • (2004) J Biol Chem , vol.279 , pp. 38486-38494
    • Shibata, H.1    Kashiwayama, Y.2    Imanaka, T.3    Kato, H.4
  • 73
    • 0036791842 scopus 로고    scopus 로고
    • Mortalin: A potential candidate for biotechnology and biomedicine
    • Wadhwa R, Taira K, Kaul SC. Mortalin: a potential candidate for biotechnology and biomedicine. Histol Histopathol. 2002;17:1173-1177.
    • (2002) Histol Histopathol , vol.17 , pp. 1173-1177
    • Wadhwa, R.1    Taira, K.2    Kaul, S.C.3
  • 74
    • 21744462307 scopus 로고    scopus 로고
    • Can hormesis be a default for dose-response?
    • Callahan BG. Can hormesis be a default for dose-response? Hum Exp Toxicol. 2005;24:271-273.
    • (2005) Hum Exp Toxicol , vol.24 , pp. 271-273
    • Callahan, B.G.1
  • 75
    • 21344466287 scopus 로고    scopus 로고
    • Understanding and modulating ageing
    • Rattan SI, Clark BF. Understanding and modulating ageing. IUBMB Life. 2005;57:297-304.
    • (2005) IUBMB Life , vol.57 , pp. 297-304
    • Rattan, S.I.1    Clark, B.F.2
  • 76
    • 0028074299 scopus 로고
    • DNA methylation and cancer
    • Laird PW, laenisch R. DNA methylation and cancer. Hum Mol Genet. 1994;3:1487-1495.
    • (1994) Hum Mol Genet , vol.3 , pp. 1487-1495
    • Laird, P.W.1    laenisch, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.