-
1
-
-
82955233157
-
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
-
Acs, K., M.S. Luijsterburg, L. Ackermann, F.A. Salomons, T. Hoppe, and N.P. Dantuma. 2011. The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat. Struct. Mol. Biol. 18:1345-1350. http://dx.doi.org/10.1038/nsmb.2188
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1345-1350
-
-
Acs, K.1
Luijsterburg, M.S.2
Ackermann, L.3
Salomons, F.A.4
Hoppe, T.5
Dantuma, N.P.6
-
2
-
-
58149295717
-
Protein arginine methylation in mammals: who, what, and why
-
Bedford, M.T., and S.G. Clarke. 2009. Protein arginine methylation in mammals: who, what, and why. Mol. Cell. 33:1-13. http://dx.doi.org/10.1016/j.molcel.2008.12.013
-
(2009)
Mol. Cell
, vol.33
, pp. 1-13
-
-
Bedford, M.T.1
Clarke, S.G.2
-
3
-
-
34447551681
-
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
-
Berkovich, E., R.J. Monnat Jr., and M.B. Kastan. 2007. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9:683-690. http://dx.doi.org/10.1038/ncb1599
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 683-690
-
-
Berkovich, E.1
Monnat Jr., R.J.2
Kastan, M.B.3
-
4
-
-
43149118801
-
Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites
-
Berkovich, E., R.J. Monnat Jr., and M.B. Kastan. 2008. Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat. Protoc. 3:915-922. http://dx.doi.org/10.1038/nprot.2008.54
-
(2008)
Nat. Protoc
, vol.3
, pp. 915-922
-
-
Berkovich, E.1
Monnat Jr., R.J.2
Kastan, M.B.3
-
5
-
-
79955627875
-
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome
-
Bohgaki, T., M. Bohgaki, R. Cardoso, S. Panier, D. Zeegers, L. Li, G.S. Stewart, O. Sanchez, M.P. Hande, D. Durocher, et al. 2011. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. 7:e1001381. http://dx.doi.org/10.1371/journal.pgen.1001381
-
(2011)
PLoS Genet
, vol.7
-
-
Bohgaki, T.1
Bohgaki, M.2
Cardoso, R.3
Panier, S.4
Zeegers, D.5
Li, L.6
Stewart, G.S.7
Sanchez, O.8
Hande, M.P.9
Durocher, D.10
-
6
-
-
58749092121
-
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites
-
Borde, V., N. Robine, W. Lin, S. Bonfils, V. Géli, and A. Nicolas. 2009. Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J. 28:99-111. http://dx.doi.org/10.1038/emboj.2008.257
-
(2009)
EMBO J
, vol.28
, pp. 99-111
-
-
Borde, V.1
Robine, N.2
Lin, W.3
Bonfils, S.4
Géli, V.5
Nicolas, A.6
-
7
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S.F., E. Callén, N. Wong, H.T. Chen, F. Polato, A. Gunn, A. Bothmer, N. Feldhahn, O. Fernandez-Capetillo, L. Cao, et al. 2010. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 141:243-254. http://dx.doi.org/10.1016/j.cell.2010.03.012
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callén, E.2
Wong, N.3
Chen, H.T.4
Polato, F.5
Gunn, A.6
Bothmer, A.7
Feldhahn, N.8
Fernandez-Capetillo, O.9
Cao, L.10
-
8
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste, A., O. Fernandez-Capetillo, M.J. Kruhlak, D.R. Pilch, D.W. Staudt, A. Lee, R.F. Bonner, W.M. Bonner, and A. Nussenzweig. 2003. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5:675-679. http://dx.doi.org/10.1038/ncb1004
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
9
-
-
76749123506
-
Genetics. Genetic control of hotspots
-
Cheung, V.G., S.L. Sherman, and E. Feingold. 2010. Genetics. Genetic control of hotspots. Science. 327:791-792. http://dx.doi.org/10.1126/science.1187155
-
(2010)
Science
, vol.327
, pp. 791-792
-
-
Cheung, V.G.1
Sherman, S.L.2
Feingold, E.3
-
10
-
-
79952314830
-
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
-
Chiolo, I., A. Minoda, S.U. Colmenares, A. Polyzos, S.V. Costes, and G.H. Karpen. 2011. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 144:732-744. http://dx.doi.org/10.1016/j.cell.2011.02.012
-
(2011)
Cell
, vol.144
, pp. 732-744
-
-
Chiolo, I.1
Minoda, A.2
Colmenares, S.U.3
Polyzos, A.4
Costes, S.V.5
Karpen, G.H.6
-
11
-
-
78649349810
-
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
-
Chou, D.M., B. Adamson, N.E. Dephoure, X. Tan, A.C. Nottke, K.E. Hurov, S.P. Gygi, M.P. Colaiácovo, and S.J. Elledge. 2010. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc. Natl. Acad. Sci. USA. 107:18475-18480. http://dx.doi.org/10.1073/pnas.1012946107
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18475-18480
-
-
Chou, D.M.1
Adamson, B.2
Dephoure, N.E.3
Tan, X.4
Nottke, A.C.5
Hurov, K.E.6
Gygi, S.P.7
Colaiácovo, M.P.8
Elledge, S.J.9
-
12
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia, A., and S.J. Elledge. 2010. The DNA damage response: making it safe to play with knives. Mol. Cell. 40:179-204. http://dx.doi.org/10.1016/j.molcel.2010.09.019
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
13
-
-
43249102851
-
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
-
Cloos, P.A., J. Christensen, K. Agger, and K. Helin. 2008. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev. 22:1115-1140. http://dx.doi.org/10.1101/gad.1652908
-
(2008)
Genes Dev
, vol.22
, pp. 1115-1140
-
-
Cloos, P.A.1
Christensen, J.2
Agger, K.3
Helin, K.4
-
14
-
-
77957684964
-
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins
-
Coster, G., and M. Goldberg. 2010. The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus. 1:166-178. http://dx.doi.org/10.4161/nucl.1.2.11176
-
(2010)
Nucleus
, vol.1
, pp. 166-178
-
-
Coster, G.1
Goldberg, M.2
-
15
-
-
80555127349
-
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation
-
Dango, S., N. Mosammaparast, M.E. Sowa, L.J. Xiong, F. Wu, K. Park, M. Rubin, S. Gygi, J.W. Harper, and Y. Shi. 2011. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. Mol. Cell. 44:373-384. http://dx.doi.org/10.1016/j.molcel.2011.08.039
-
(2011)
Mol. Cell
, vol.44
, pp. 373-384
-
-
Dango, S.1
Mosammaparast, N.2
Sowa, M.E.3
Xiong, L.J.4
Wu, F.5
Park, K.6
Rubin, M.7
Gygi, S.8
Harper, J.W.9
Shi, Y.10
-
16
-
-
84861915893
-
Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination
-
Daniel, J.A., and A. Nussenzweig. 2012. Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination. Biochim. Biophys. Acta. 1819:733-738. http://dx.doi.org/10.1016/j.bbagrm.2012.01.019
-
(2012)
Biochim. Biophys. Acta
, vol.1819
, pp. 733-738
-
-
Daniel, J.A.1
Nussenzweig, A.2
-
17
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil, C., N. Mailand, S. Bekker-Jensen, P. Menard, D.H. Larsen, R. Pepperkok, J. Ellenberg, S. Panier, D. Durocher, J. Bartek, et al. 2009. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell. 136:435-446. http://dx.doi.org/10.1016/j.cell.2008.12.041
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
Ellenberg, J.7
Panier, S.8
Durocher, D.9
Bartek, J.10
-
18
-
-
70349308060
-
53BP1: function and mechanisms of focal recruitment
-
FitzGerald, J.E., M. Grenon, and N.F. Lowndes. 2009. 53BP1: function and mechanisms of focal recruitment. Biochem. Soc. Trans. 37:897-904. http://dx.doi.org/10.1042/BST0370897
-
(2009)
Biochem. Soc. Trans
, vol.37
, pp. 897-904
-
-
FitzGerald, J.E.1
Grenon, M.2
Lowndes, N.F.3
-
19
-
-
84879888213
-
53BP1 is a reader of the DNA-damageinduced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte, A., M.D. Canny, C. Escribano-Díaz, A. Orthwein, C.C. Leung, H. Huang, M.C. Landry, J. Kitevski-LeBlanc, S.M. Noordermeer, F. Sicheri, and D. Durocher. 2013. 53BP1 is a reader of the DNA-damageinduced H2A Lys 15 ubiquitin mark. Nature. 499:50-54. http://dx.doi.org/10.1038/nature12318
-
(2013)
Nature
, vol.499
, pp. 50-54
-
-
Fradet-Turcotte, A.1
Canny, M.D.2
Escribano-Díaz, C.3
Orthwein, A.4
Leung, C.C.5
Huang, H.6
Landry, M.C.7
Kitevski-LeBlanc, J.8
Noordermeer, S.M.9
Sicheri, F.10
Durocher, D.11
-
20
-
-
33846690407
-
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
-
Garcia-Bassets, I., Y.S. Kwon, F. Telese, G.G. Prefontaine, K.R. Hutt, C.S. Cheng, B.G. Ju, K.A. Ohgi, J. Wang, L. Escoubet-Lozach, et al. 2007. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 128:505-518. http://dx.doi.org/10.1016/j.cell.2006.12.038
-
(2007)
Cell
, vol.128
, pp. 505-518
-
-
Garcia-Bassets, I.1
Kwon, Y.S.2
Telese, F.3
Prefontaine, G.G.4
Hutt, K.R.5
Cheng, C.S.6
Ju, B.G.7
Ohgi, K.A.8
Wang, J.9
Escoubet-Lozach, L.10
-
21
-
-
84863793933
-
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase
-
Gatti, M., S. Pinato, E. Maspero, P. Soffientini, S. Polo, and L. Penengo. 2012. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle. 11:2538-2544. http://dx.doi.org/10.4161/cc.20919
-
(2012)
Cell Cycle
, vol.11
, pp. 2538-2544
-
-
Gatti, M.1
Pinato, S.2
Maspero, E.3
Soffientini, P.4
Polo, S.5
Penengo, L.6
-
22
-
-
79956086415
-
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair
-
Ginjala, V., K. Nacerddine, A. Kulkarni, J. Oza, S.J. Hill, M. Yao, E. Citterio, M. van Lohuizen, and S. Ganesan. 2011. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol. Cell. Biol. 31:1972-1982. http://dx.doi.org/10.1128/MCB.00981-10
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 1972-1982
-
-
Ginjala, V.1
Nacerddine, K.2
Kulkarni, A.3
Oza, J.4
Hill, S.J.5
Yao, M.6
Citterio, E.7
van Lohuizen, M.8
Ganesan, S.9
-
23
-
-
0037188526
-
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
-
Hakimi, M.A., D.A. Bochar, J. Chenoweth, W.S. Lane, G. Mandel, and R. Shiekhattar. 2002. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc. Natl. Acad. Sci. USA. 99:7420-7425. http://dx.doi.org/10.1073/pnas.112008599
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 7420-7425
-
-
Hakimi, M.A.1
Bochar, D.A.2
Chenoweth, J.3
Lane, W.S.4
Mandel, G.5
Shiekhattar, R.6
-
24
-
-
0037470142
-
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes
-
Hakimi, M.A., Y. Dong, W.S. Lane, D.W. Speicher, and R. Shiekhattar. 2003. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J. Biol. Chem. 278:7234-7239. http://dx.doi.org/10.1074/jbc. M208992200
-
(2003)
J. Biol. Chem
, vol.278
, pp. 7234-7239
-
-
Hakimi, M.A.1
Dong, Y.2
Lane, W.S.3
Speicher, D.W.4
Shiekhattar, R.5
-
25
-
-
34548513035
-
p53 is regulated by the lysine demethylase LSD1
-
Huang, J., R. Sengupta, A.B. Espejo, M.G. Lee, J.A. Dorsey, M. Richter, S. Opravil, R. Shiekhattar, M.T. Bedford, T. Jenuwein, and S.L. Berger. 2007. p53 is regulated by the lysine demethylase LSD1. Nature. 449:105-108. http://dx.doi.org/10.1038/nature06092
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
Sengupta, R.2
Espejo, A.B.3
Lee, M.G.4
Dorsey, J.A.5
Richter, M.6
Opravil, S.7
Shiekhattar, R.8
Bedford, M.T.9
Jenuwein, T.10
Berger, S.L.11
-
26
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
Huen, M.S., R. Grant, I. Manke, K. Minn, X. Yu, M.B. Yaffe, and J. Chen. 2007. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 131:901-914. http://dx.doi.org/10.1016/j.cell.2007.09.041
-
(2007)
Cell
, vol.131
, pp. 901-914
-
-
Huen, M.S.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.5
Yaffe, M.B.6
Chen, J.7
-
27
-
-
75149189204
-
BRCA1 and its toolbox for the maintenance of genome integrity
-
Huen, M.S., S.M. Sy, and J. Chen. 2010. BRCA1 and its toolbox for the maintenance of genome integrity. Nat. Rev. Mol. Cell Biol. 11:138-148. http://dx.doi.org/10.1038/nrm2831
-
(2010)
Nat. Rev. Mol. Cell Biol
, vol.11
, pp. 138-148
-
-
Huen, M.S.1
Sy, S.M.2
Chen, J.3
-
28
-
-
77957748289
-
BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
-
Ismail, I.H., C. Andrin, D. McDonald, and M.J. Hendzel. 2010. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J. Cell Biol. 191:45-60. http://dx.doi.org/10.1083/jcb.201003034
-
(2010)
J. Cell Biol
, vol.191
, pp. 45-60
-
-
Ismail, I.H.1
Andrin, C.2
McDonald, D.3
Hendzel, M.J.4
-
29
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson, S.P., and J. Bartek. 2009. The DNA-damage response in human biology and disease. Nature. 461:1071-1078. http://dx.doi.org/10.1038/nature08467
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
30
-
-
33947513027
-
Regulation of histone methylation by demethylimination and demethylation
-
Klose, R.J., and Y. Zhang. 2007. Regulation of histone methylation by demethylimination and demethylation. Nat. Rev. Mol. Cell Biol. 8:307-318. http://dx.doi.org/10.1038/nrm2143
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 307-318
-
-
Klose, R.J.1
Zhang, Y.2
-
31
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
Kolas, N.K., J.R. Chapman, S. Nakada, J. Ylanko, R. Chahwan, F.D. Sweeney, S. Panier, M. Mendez, J. Wildenhain, T.M. Thomson, et al. 2007. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science. 318:1637-1640. http://dx.doi.org/10.1126/science.1150034
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
Panier, S.7
Mendez, M.8
Wildenhain, J.9
Thomson, T.M.10
-
32
-
-
77956379478
-
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
-
Larsen, D.H., C. Poinsignon, T. Gudjonsson, C. Dinant, M.R. Payne, F.J. Hari, J.M. Rendtlew Danielsen, P. Menard, J.C. Sand, M. Stucki, et al. 2010. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J. Cell Biol. 190:731-740. http://dx.doi.org/10.1083/jcb.200912135
-
(2010)
J. Cell Biol
, vol.190
, pp. 731-740
-
-
Larsen, D.H.1
Poinsignon, C.2
Gudjonsson, T.3
Dinant, C.4
Payne, M.R.5
Hari, F.J.6
Rendtlew Danielsen, J.M.7
Menard, P.8
Sand, J.C.9
Stucki, M.10
-
33
-
-
25144519737
-
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
-
Lee, M.G., C. Wynder, N. Cooch, and R. Shiekhattar. 2005. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature. 437:432-435.
-
(2005)
Nature
, vol.437
, pp. 432-435
-
-
Lee, M.G.1
Wynder, C.2
Cooch, N.3
Shiekhattar, R.4
-
34
-
-
84861895067
-
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
-
Luijsterburg, M.S., K. Acs, L. Ackermann, W.W. Wiegant, S. Bekker-Jensen, D.H. Larsen, K.K. Khanna, H. van Attikum, N. Mailand, and N.P. Dantuma. 2012. A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J. 31:2511-2527. http://dx.doi.org/10.1038/emboj.2012.104
-
(2012)
EMBO J
, vol.31
, pp. 2511-2527
-
-
Luijsterburg, M.S.1
Acs, K.2
Ackermann, L.3
Wiegant, W.W.4
Bekker-Jensen, S.5
Larsen, D.H.6
Khanna, K.K.7
van Attikum, H.8
Mailand, N.9
Dantuma, N.P.10
-
35
-
-
77952011032
-
LSD1 is required for chromosome segregation during mitosis
-
Lv, S., W. Bu, H. Jiao, B. Liu, L. Zhu, H. Zhao, J. Liao, J. Li, and X. Xu. 2010. LSD1 is required for chromosome segregation during mitosis. Eur. J. Cell Biol. 89:557-563. http://dx.doi.org/10.1016/j.ejcb.2010.01.004
-
(2010)
Eur. J. Cell Biol
, vol.89
, pp. 557-563
-
-
Lv, S.1
Bu, W.2
Jiao, H.3
Liu, B.4
Zhu, L.5
Zhao, H.6
Liao, J.7
Li, J.8
Xu, X.9
-
36
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand, N., S. Bekker-Jensen, H. Faustrup, F. Melander, J. Bartek, C. Lukas, and J. Lukas. 2007. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell. 131:887-900. http://dx.doi.org/10.1016/j.cell.2007.09.040
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
37
-
-
84859895529
-
RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
-
Mallette, F.A., F. Mattiroli, G. Cui, L.C. Young, M.J. Hendzel, G. Mer, T.K. Sixma, and S. Richard. 2012. RNF8-and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J. 31:1865-1878. http://dx.doi.org/10.1038/emboj.2012.47
-
(2012)
EMBO J
, vol.31
, pp. 1865-1878
-
-
Mallette, F.A.1
Mattiroli, F.2
Cui, G.3
Young, L.C.4
Hendzel, M.J.5
Mer, G.6
Sixma, T.K.7
Richard, S.8
-
38
-
-
84866388311
-
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
-
Mattiroli, F., J.H. Vissers, W.J. van Dijk, P. Ikpa, E. Citterio, W. Vermeulen, J.A. Marteijn, and T.K. Sixma. 2012. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell. 150:1182-1195. http://dx.doi.org/10.1016/j.cell.2012.08.005
-
(2012)
Cell
, vol.150
, pp. 1182-1195
-
-
Mattiroli, F.1
Vissers, J.H.2
van Dijk, W.J.3
Ikpa, P.4
Citterio, E.5
Vermeulen, W.6
Marteijn, J.A.7
Sixma, T.K.8
-
39
-
-
80455145246
-
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
-
Meerang, M., D. Ritz, S. Paliwal, Z. Garajova, M. Bosshard, N. Mailand, P. Janscak, U. Hübscher, H. Meyer, and K. Ramadan. 2011. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol. 13:1376-1382. http://dx.doi.org/10.1038/ncb2367
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 1376-1382
-
-
Meerang, M.1
Ritz, D.2
Paliwal, S.3
Garajova, Z.4
Bosshard, M.5
Mailand, N.6
Janscak, P.7
Hübscher, U.8
Meyer, H.9
Ramadan, K.10
-
40
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger, E., M. Wissmann, N. Yin, J.M. Müller, R. Schneider, A.H. Peters, T. Günther, R. Buettner, and R. Schüle. 2005. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. 437:436-439.
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
Wissmann, M.2
Yin, N.3
Müller, J.M.4
Schneider, R.5
Peters, A.H.6
Günther, T.7
Buettner, R.8
Schüle, R.9
-
41
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller, K.M., J.V. Tjeertes, J. Coates, G. Legube, S.E. Polo, S. Britton, and S.P. Jackson. 2010. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat. Struct. Mol. Biol. 17:1144-1151. http://dx.doi.org/10.1038/nsmb.1899
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 1144-1151
-
-
Miller, K.M.1
Tjeertes, J.V.2
Coates, J.3
Legube, G.4
Polo, S.E.5
Britton, S.6
Jackson, S.P.7
-
42
-
-
77953644347
-
Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases
-
Mosammaparast, N., and Y. Shi. 2010. Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu. Rev. Biochem. 79:155-179. http://dx.doi.org/10.1146/annurev.biochem.78.070907.103946
-
(2010)
Annu. Rev. Biochem
, vol.79
, pp. 155-179
-
-
Mosammaparast, N.1
Shi, Y.2
-
43
-
-
57049167675
-
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation
-
Mulligan, P., T.F. Westbrook, M. Ottinger, N. Pavlova, B. Chang, E. Macia, Y.J. Shi, J. Barretina, J. Liu, P.M. Howley, et al. 2008. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol. Cell. 32:718-726. http://dx.doi.org/10.1016/j.molcel.2008.10.025
-
(2008)
Mol. Cell
, vol.32
, pp. 718-726
-
-
Mulligan, P.1
Westbrook, T.F.2
Ottinger, M.3
Pavlova, N.4
Chang, B.5
Macia, E.6
Shi, Y.J.7
Barretina, J.8
Liu, J.9
Howley, P.M.10
-
44
-
-
30344444484
-
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
-
Murr, R., J.I. Loizou, Y.G. Yang, C. Cuenin, H. Li, Z.Q. Wang, and Z. Herceg. 2006. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat. Cell Biol. 8:91-99. http://dx.doi.org/10.1038/ncb1343
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 91-99
-
-
Murr, R.1
Loizou, J.I.2
Yang, Y.G.3
Cuenin, C.4
Li, H.5
Wang, Z.Q.6
Herceg, Z.7
-
45
-
-
0347381286
-
Immunoaffinity purification of mammalian protein complexes
-
Nakatani, Y., and V. Ogryzko. 2003. Immunoaffinity purification of mammalian protein complexes. Methods Enzymol. 370:430-444. http://dx.doi.org/10.1016/S0076-6879(03)70037-8
-
(2003)
Methods Enzymol
, vol.370
, pp. 430-444
-
-
Nakatani, Y.1
Ogryzko, V.2
-
46
-
-
79961212387
-
SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair
-
Nottke, A.C., S.E. Beese-Sims, L.F. Pantalena, V. Reinke, Y. Shi, and M.P. Colaiácovo. 2011. SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair. Proc. Natl. Acad. Sci. USA. 108: 12805-12810. http://dx.doi.org/10.1073/pnas.1102298108
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 12805-12810
-
-
Nottke, A.C.1
Beese-Sims, S.E.2
Pantalena, L.F.3
Reinke, V.4
Shi, Y.5
Colaiácovo, M.P.6
-
47
-
-
77956870690
-
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
-
Polo, S.E., A. Kaidi, L. Baskcomb, Y. Galanty, and S.P. Jackson. 2010. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J. 29:3130-3139. http://dx.doi.org/10.1038/emboj.2010.188
-
(2010)
EMBO J
, vol.29
, pp. 3130-3139
-
-
Polo, S.E.1
Kaidi, A.2
Baskcomb, L.3
Galanty, Y.4
Jackson, S.P.5
-
48
-
-
38849199681
-
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
-
Sakaue-Sawano, A., H. Kurokawa, T. Morimura, A. Hanyu, H. Hama, H. Osawa, S. Kashiwagi, K. Fukami, T. Miyata, H. Miyoshi, et al. 2008. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell. 132:487-498. http://dx.doi.org/10.1016/j.cell.2007.12.033
-
(2008)
Cell
, vol.132
, pp. 487-498
-
-
Sakaue-Sawano, A.1
Kurokawa, H.2
Morimura, T.3
Hanyu, A.4
Hama, H.5
Osawa, H.6
Kashiwagi, S.7
Fukami, K.8
Miyata, T.9
Miyoshi, H.10
-
49
-
-
34447519212
-
The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and-independent manners
-
Scoumanne, A., and X. Chen. 2007. The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and-independent manners. J. Biol. Chem. 282:15471-15475. http://dx.doi.org/10.1074/jbc. M701023200
-
(2007)
J. Biol. Chem
, vol.282
, pp. 15471-15475
-
-
Scoumanne, A.1
Chen, X.2
-
50
-
-
77953720192
-
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
-
Shanbhag, N.M., I.U. Rafalska-Metcalf, C. Balane-Bolivar, S.M. Janicki, and R.A. Greenberg. 2010. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell. 141:970-981. http://dx.doi.org/10.1016/j.cell.2010.04.038
-
(2010)
Cell
, vol.141
, pp. 970-981
-
-
Shanbhag, N.M.1
Rafalska-Metcalf, I.U.2
Balane-Bolivar, C.3
Janicki, S.M.4
Greenberg, R.A.5
-
51
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi, Y., F. Lan, C. Matson, P. Mulligan, J.R. Whetstine, P.A. Cole, R.A. Casero, and Y. Shi. 2004. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 119:941-953. http://dx.doi.org/10.1016/j.cell.2004.12.012
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
Lan, F.2
Matson, C.3
Mulligan, P.4
Whetstine, J.R.5
Cole, P.A.6
Casero, R.A.7
Shi, Y.8
-
52
-
-
24944535335
-
Regulation of LSD1 histone demethylase activity by its associated factors
-
Shi, Y.J., C. Matson, F. Lan, S. Iwase, T. Baba, and Y. Shi. 2005. Regulation of LSD1 histone demethylase activity by its associated factors. Mol. Cell. 19:857-864. http://dx.doi.org/10.1016/j.molcel.2005.08.027
-
(2005)
Mol. Cell
, vol.19
, pp. 857-864
-
-
Shi, Y.J.1
Matson, C.2
Lan, F.3
Iwase, S.4
Baba, T.5
Shi, Y.6
-
53
-
-
77956387556
-
The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage
-
Smeenk, G., W.W. Wiegant, H. Vrolijk, A.P. Solari, A. Pastink, and H. van Attikum. 2010. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J. Cell Biol. 190:741-749. http://dx.doi.org/10.1083/jcb.201001048
-
(2010)
J. Cell Biol
, vol.190
, pp. 741-749
-
-
Smeenk, G.1
Wiegant, W.W.2
Vrolijk, H.3
Solari, A.P.4
Pastink, A.5
van Attikum, H.6
-
54
-
-
84872249432
-
Spp1, a member of the Set1 complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes
-
Sommermeyer, V., C. Béneut, E. Chaplais, M.E. Serrentino, and V. Borde. 2013. Spp1, a member of the Set1 complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes. Mol. Cell. 49:43-54.
-
(2013)
Mol. Cell
, vol.49
, pp. 43-54
-
-
Sommermeyer, V.1
Béneut, C.2
Chaplais, E.3
Serrentino, M.E.4
Borde, V.5
-
55
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart, G.S., B. Wang, C.R. Bignell, A.M. Taylor, and S.J. Elledge. 2003. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 421:961-966. http://dx.doi.org/10.1038/nature01446
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
56
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
Stewart, G.S., S. Panier, K. Townsend, A.K. Al-Hakim, N.K. Kolas, E.S. Miller, S. Nakada, J. Ylanko, S. Olivarius, M. Mendez, et al. 2009. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell. 136:420-434. http://dx.doi.org/10.1016/j.cell.2008.12.042
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
Nakada, S.7
Ylanko, J.8
Olivarius, S.9
Mendez, M.10
-
57
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl, B.D., and C.D. Allis. 2000. The language of covalent histone modifications. Nature. 403:41-45. http://dx.doi.org/10.1038/47412
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
58
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki, M., J.A. Clapperton, D. Mohammad, M.B. Yaffe, S.J. Smerdon, and S.P. Jackson. 2005. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 123:1213-1226. http://dx.doi.org/10.1016/j.cell.2005.09.038
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
59
-
-
79958865837
-
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
-
Toledo, L.I., M. Murga, R. Zur, R. Soria, A. Rodriguez, S. Martinez, J. Oyarzabal, J. Pastor, J.R. Bischoff, and O. Fernandez-Capetillo. 2011. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat. Struct. Mol. Biol. 18:721-727. http://dx.doi.org/10.1038/nsmb.2076
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 721-727
-
-
Toledo, L.I.1
Murga, M.2
Zur, R.3
Soria, R.4
Rodriguez, A.5
Martinez, S.6
Oyarzabal, J.7
Pastor, J.8
Bischoff, J.R.9
Fernandez-Capetillo, O.10
-
60
-
-
65149084552
-
Crosstalk between histone modifications during the DNA damage response
-
van Attikum, H., and S.M. Gasser. 2009. Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol. 19:207-217. http://dx.doi.org/10.1016/j.tcb.2009.03.001
-
(2009)
Trends Cell Biol
, vol.19
, pp. 207-217
-
-
van Attikum, H.1
Gasser, S.M.2
-
61
-
-
7244234099
-
Role of histone H2A ubiquitination in Polycomb silencing
-
Wang, H., L. Wang, H. Erdjument-Bromage, M. Vidal, P. Tempst, R.S. Jones, and Y. Zhang. 2004. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 431:873-878. http://dx.doi.org/10.1038/nature02985
-
(2004)
Nature
, vol.431
, pp. 873-878
-
-
Wang, H.1
Wang, L.2
Erdjument-Bromage, H.3
Vidal, M.4
Tempst, P.5
Jones, R.S.6
Zhang, Y.7
-
62
-
-
34247348215
-
Opposing LSD1 complexes function in developmental gene activation and repression programmes
-
Wang, J., K. Scully, X. Zhu, L. Cai, J. Zhang, G.G. Prefontaine, A. Krones, K.A. Ohgi, P. Zhu, I. Garcia-Bassets, et al. 2007. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 446:882-887. http://dx.doi.org/10.1038/nature05671
-
(2007)
Nature
, vol.446
, pp. 882-887
-
-
Wang, J.1
Scully, K.2
Zhu, X.3
Cai, L.4
Zhang, J.5
Prefontaine, G.G.6
Krones, A.7
Ohgi, K.A.8
Zhu, P.9
Garcia-Bassets, I.10
-
63
-
-
68749108259
-
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
-
Wang, Y., H. Zhang, Y. Chen, Y. Sun, F. Yang, W. Yu, J. Liang, L. Sun, X. Yang, L. Shi, et al. 2009. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 138:660-672. http://dx.doi.org/10.1016/j.cell.2009.05.050
-
(2009)
Cell
, vol.138
, pp. 660-672
-
-
Wang, Y.1
Zhang, H.2
Chen, Y.3
Sun, Y.4
Yang, F.5
Yu, W.6
Liang, J.7
Sun, L.8
Yang, X.9
Shi, L.10
-
64
-
-
27644593844
-
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice
-
Ward, I.M., S. Difilippantonio, K. Minn, M.D. Mueller, J.R. Molina, X. Yu, C.S. Frisk, T. Ried, A. Nussenzweig, and J. Chen. 2005. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol. Cell. Biol. 25:10079-10086. http://dx.doi.org/10.1128/MCB.25.22.10079-10086.2005
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 10079-10086
-
-
Ward, I.M.1
Difilippantonio, S.2
Minn, K.3
Mueller, M.D.4
Molina, J.R.5
Yu, X.6
Frisk, C.S.7
Ried, T.8
Nussenzweig, A.9
Chen, J.10
-
65
-
-
33745221412
-
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase
-
Weinstock, D.M., K. Nakanishi, H.R. Helgadottir, and M. Jasin. 2006. Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol. 409:524-540. http://dx.doi.org/10.1016/S0076-6879(05)09031-2
-
(2006)
Methods Enzymol
, vol.409
, pp. 524-540
-
-
Weinstock, D.M.1
Nakanishi, K.2
Helgadottir, H.R.3
Jasin, M.4
-
66
-
-
37349096996
-
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
-
Xie, A., A. Hartlerode, M. Stucki, S. Odate, N. Puget, A. Kwok, G. Nagaraju, C. Yan, F.W. Alt, J. Chen, et al. 2007. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell. 28:1045-1057. http://dx.doi.org/10.1016/j.molcel.2007.12.005
-
(2007)
Mol. Cell
, vol.28
, pp. 1045-1057
-
-
Xie, A.1
Hartlerode, A.2
Stucki, M.3
Odate, S.4
Puget, N.5
Kwok, A.6
Nagaraju, G.7
Yan, C.8
Alt, F.W.9
Chen, J.10
-
67
-
-
33746435258
-
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase
-
Yang, M., C.B. Gocke, X. Luo, D. Borek, D.R. Tomchick, M. Machius, Z. Otwinowski, and H. Yu. 2006. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol. Cell. 23:377-387. http://dx.doi.org/10.1016/j.molcel.2006.07.012
-
(2006)
Mol. Cell
, vol.23
, pp. 377-387
-
-
Yang, M.1
Gocke, C.B.2
Luo, X.3
Borek, D.4
Tomchick, D.R.5
Machius, M.6
Otwinowski, Z.7
Yu, H.8
-
68
-
-
0035852637
-
CoREST is an integral component of the CoREST-human histone deacetylase complex
-
You, A., J.K. Tong, C.M. Grozinger, and S.L. Schreiber. 2001. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc. Natl. Acad. Sci. USA. 98:1454-1458. http://dx.doi.org/10.1073/pnas.98.4.1454
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1454-1458
-
-
You, A.1
Tong, J.K.2
Grozinger, C.M.3
Schreiber, S.L.4
-
69
-
-
77249142841
-
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system
-
Zibetti, C., A. Adamo, C. Binda, F. Forneris, E. Toffolo, C. Verpilli, E. Ginellli, A. Mattevi, C. Sala, and E. Battaglioli. 2010. Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J. Neurosci. 30:2521-2532. http://dx.doi.org/10.1523/JNEUROSCI.5500-09.2010
-
(2010)
J. Neurosci
, vol.30
, pp. 2521-2532
-
-
Zibetti, C.1
Adamo, A.2
Binda, C.3
Forneris, F.4
Toffolo, E.5
Verpilli, C.6
Ginellli, E.7
Mattevi, A.8
Sala, C.9
Battaglioli, E.10
-
70
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATMand KAP-1 dependent pathway
-
Ziv, Y., D. Bielopolski, Y. Galanty, C. Lukas, Y. Taya, D.C. Schultz, J. Lukas, S. Bekker-Jensen, J. Bartek, and Y. Shiloh. 2006. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATMand KAP-1 dependent pathway. Nat. Cell Biol. 8:870-876. http://dx.doi.org/10.1038/ncb1446
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
|