Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4824-4830

  Stroth, Nikolas ^a   Niso, Mauro ^b   Colabufo, Nicola A ^b   Perrone, Roberto ^b   Svenningsson, Per ^a   Lacivita, Enza ^b   Leopoldo, Marcello ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

5 HT1AR; cAMP; Functional selectivity; G protein coupled receptor; Long chain arylpiperazines; Arrestin 2

Indexed keywords

ARYLPIPERAZINE AGONIST; BETA ARRESTIN 2; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; PIPERAZINE DERIVATIVE; SEROTONIN; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; BETA ARRESTIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PIPERAZINE; RETINA S ANTIGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; DRUG TARGETING; ENZYME PHOSPHORYLATION; NONHUMAN; SIDE EFFECT; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HAMSTER; HUMAN; METABOLISM; PHOSPHORYLATION;

ANIMALS; ARRESTINS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 84937525967     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.05.042     Document Type: Article

References (38)

1. T.K. Bjarnadóttir, D.E. Gloriam, S.H. Hellstrand, H. Kristiansson, R. Fredriksson, and H.B. Schiöth Genomics 88 2006 263
2. M.C. Lagerström, and H.B. Schiöth Nat. Rev. Drug Disc. 7 2008 339
3. L.M. Luttrell Methods Mol. Biol. 332 2006 3
4. E. Reiter, S. Ahn, A.K. Shukla, and R.J. Lefkowitz Annu. Rev. Pharmacol. Toxicol. 52 2012 179
5. S. Galandrin, G. Oligny-Longpre, and M. Bouvier Trends Pharmacol. Sci. 28 2007 423
6. T. Kenakin, and A. Christopoulos Nat. Rev. Drug Disc. 12 2013 205
7. A.L. Hopkins, and C.R. Groom Nat. Rev. Drug Disc. 1 2002 727
8. J.P. Overington, B. Al-Lazikani, and A.L. Hopkins Nat. Rev. Drug Disc. 5 2006 993
9. D. Hoyer, J.P. Hannon, and G.R. Martin Pharmacol. Biochem. Behav. 71 2002 533
10. E. Lacivita, M. Leopoldo, F. Berardi, and R. Perrone Curr. Top. Med. Chem. 8 2008 1024
11. T.J. Pucadyil, S. Kalipatnapu, and A. Chattopadhyay Cell. Mol. Neurobiol. 25 2005 553
12. A. Newman-Tancredi Neuropsychiatry 1 2011 149
13. N. Stroth, and P. Svenningsson WIREs Membr. Transp. Signaling 1 2012 453
14. D.O. Borroto-Escuela, F. Corrales, M. Narvaez, J. Oflijan, L.F. Agnati, M. Palkovits, and K. Fuxe Biochem. Biophys. Res. Commun. 441 2013 387
15. E. Lacivita, P. Di Pilato, P. De Giorgio, N.A. Colabufo, F. Berardi, R. Perrone, and M. Leopoldo Expert Opin. Ther. Pat. 22 2012 887
16. X. Chen, M.F. Sassano, L. Zheng, V. Setola, M. Chen, X. Bai, S.V. Frye, W.C. Wetsel, B.L. Roth, and J. Jin J. Med. Chem. 55 2012 7141
17. R. Perrone, F. Berardi, N.A. Colabufo, M. Leopoldo, E. Lacivita, V. Tortorella, A. Leonardi, E. Poggesi, and R. Testa J. Med. Chem. 44 2001 4431
18. B.Y. Ho, A. Karschin, T. Branchek, N. Davidson, and H.A. Lester FEBS Lett. 312 1992 259
19. K.L. Evans, J.D. Cropper, K.A. Berg, and W.P. Clarke J. Pharmacol. Exp. Ther. 297 2001 1025
20. J.H. Turner, M.N. Garnovskaya, and J.R. Raymond Biochim. Biophys. Acta 1773 2007 391
21. A. Christopoulos, M.K. Grant, N. Ayoubzadeh, O.N. Kim, P. Sauerberg, L. Jeppesen, and E.E. El-Fakahany J. Pharmacol. Exp. Ther. 298 2001 1260
22. L.J. Cornfield, G. Lambert, L.E. Arvidsson, C. Mellin, J. Vallgarda, U. Hacksell, and D.L. Nelson Mol. Pharmacol. 39 1991 780
23. A. Newman-Tancredi, D. Cussac, L. Marini, and M.J. Millan Mol. Pharmacol. 62 2002 590
24. A. Malmberg, and P.G. Strange J. Neurochem. 75 2000 1283
25. F.J. Ehlert Naunyn Schmiedebergs Arch. Pharmacol. 377 2008 549
26. T. Kenakin, C. Watson, V. Muniz-Medina, A. Christopoulos, and S. Novick ACS Chem. Neurosci. 3 2012 193
27. M.T. Drake, J.D. Violin, E.J. Whalen, J.W. Wisler, S.K. Shenoy, and R.J. Lefkowitz J. Biol. Chem. 283 2008 5669
28. S. Rajagopal, K. Rajagopal, and R.J. Lefkowitz Nat. Rev. Drug Disc. 9 2010 373
29. J.D. Urban, W.P. Clarke, M. von Zastrow, D.E. Nichols, B. Kobilka, H. Weinstein, J.A. Javitch, B.L. Roth, A. Christopoulos, P.M. Sexton, K.J. Miller, M. Spedding, and R.B. Mailman J. Pharmacol. Exp. Ther. 320 2007 1
30. D.G. Soergel, R.A. Subach, N. Burnham, M.W. Lark, I.E. James, B.M. Sadler, F. Skobieranda, J.D. Violin, and L.R. Webster Pain 155 2014 1829
31. W. Stallaert, A. Christopoulos, and M. Bouvier Expert Opin. Drug Disc. 6 2011 811
32. S. Rajagopal, S. Ahn, D.H. Rominger, W. Gowen-MacDonald, C.M. Lam, S.M. Dewire, J.D. Violin, and R.J. Lefkowitz Mol. Pharmacol. 80 2011 367
33. A. Varrault, L. Journot, Y. Audigier, and J. Bockaert Mol. Pharmacol. 41 1992 999
34. F.D. Yocca, L. Iben, and E. Meller Mol. Pharmacol. 41 1992 1066
35. D. Hoyer, and H.W. Boddeke Trends Pharmacol. Sci. 14 1993 270
36. A. Newman-Tancredi, J.C. Martel, M.B. Assie, J. Buritova, E. Lauressergues, C. Cosi, P. Heusler, L. Bruins Slot, F.C. Colpaert, B. Vacher, and D. Cussac Br. J. Pharmacol. 156 2009 338
37. P. Heusler, A. Newman-Tancredi, T. Loock, and D. Cussac Eur. J. Pharmacol. 581 2008 37
38. R. Perrone, F. Berardi, N.A. Colabufo, M. Leopoldo, V. Tortorella, F. Fiorentini, V. Olgiati, A. Ghiglieri, and S. Govoni J. Med. Chem. 38 1995 942