trans-4-[4-(methoxyphenyl)cyclohexyl]-1-arylpiperazines: A new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-y1)propyl]-1-arylpiperazines

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4431-4442

  Perrone, R ^a   Berardi, F ^a   Colabufo, N A ^a   Leopoldo, M ^a   Lacivita, E ^a   Tortorella, V ^a   Leonardi, Amedeo ^b   Poggesi, Elena ^b   Testa, Rodolfo ^b  

^a Dipartimento Farmaco Chimico   (Italy)

^b Recordati SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 [4 (3 METHOXYPHENYL)CYCLOHEXYL] 1 (2 PYRIDINYL)PIPERAZINE; ALPHA 1 ADRENERGIC RECEPTOR; BUSPIRONE; DOPAMINE 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; PHENTOLAMINE; PIPERAZINE DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CIS ISOMER; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; FOREFOOT; HUMAN; MALE; NONHUMAN; PARAMETER; RAT; RAT STRAIN; REACTION ANALYSIS; SEROTONIN SYNDROME; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYMPTOM; TRANS ISOMER;

ANIMALS; BRAIN; ETHYLAMINES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HELA CELLS; HUMANS; LIGANDS; MOLECULAR CONFORMATION; PIPERAZINES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035818892     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010866v     Document Type: Article

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