Site-directed mutations in the third intracellular loop of the serotonin 5-HT(1A) receptor alter G protein coupling from G(i) to G(s) in a ligand-dependent manner

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1283-1293

  Malmberg, A ^a,b   Strange, Philip G ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

5 Hydroxytryptamine(1A) receptors; G protein; Inverse agonists; NAD 299; Serotonin; Site directed mutations

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; SEROTONIN 1A RECEPTOR;

ARTICLE; HUMAN; HUMAN CELL; LIGAND BINDING; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

EID: 0033836383     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.751283.x     Document Type: Article

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