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Volumn 16, Issue 7, 2015, Pages 16414-16439

Alemtuzumab in multiple sclerosis: Mechanism of action and beyond

Author keywords

Alemtuzumab; CD52; Experimental autoimmune encephalomyelitis (EAE); Mechanism of action; Multiple sclerosis; Secondary autoimmune disease

Indexed keywords

ALEMTUZUMAB; BETA1A INTERFERON; INTERLEUKIN 21; INTERLEUKIN 7; MONOCLONAL ANTIBODY;

EID: 84937501642     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160716414     Document Type: Review
Times cited : (166)

References (105)
  • 1
    • 84921047834 scopus 로고    scopus 로고
    • Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use
    • Havrdova, E.; Horakova, D.; Kovarova, I. Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use. Ther. Adv. Neurol. Disord. 2015, 8, 31–45.
    • (2015) Ther. Adv. Neurol. Disord , vol.8 , pp. 31-45
    • Havrdova, E.1    Horakova, D.2    Kovarova, I.3
  • 2
    • 84904020925 scopus 로고    scopus 로고
    • Alemtuzumab: The advantages and challenges of a novel therapy in MS
    • Menge, T.; Stuve, O.; Kieseier, B.C.; Hartung, H.P. Alemtuzumab: The advantages and challenges of a novel therapy in MS. Neurology 2014, 83, 87–97.
    • (2014) Neurology , vol.83 , pp. 87-97
    • Menge, T.1    Stuve, O.2    Kieseier, B.C.3    Hartung, H.P.4
  • 3
    • 84874948941 scopus 로고    scopus 로고
    • Multiple sclerosis: Reprogramming the immune repertoire with alemtuzumab in MS
    • Wiendl, H.; Kieseier, B. Multiple sclerosis: Reprogramming the immune repertoire with alemtuzumab in MS. Nat. Rev. Neurol. 2013, 9, 125–126.
    • (2013) Nat. Rev. Neurol , vol.9 , pp. 125-126
    • Wiendl, H.1    Kieseier, B.2
  • 4
    • 0021713342 scopus 로고
    • Production of functional chimaeric mouse/human antibody
    • Boulianne, G.L.; Hozumi, N.; Shulman, M.J. Production of functional chimaeric mouse/human antibody. Nature 1984, 312, 643–646.
    • (1984) Nature , vol.312 , pp. 643-646
    • Boulianne, G.L.1    Hozumi, N.2    Shulman, M.J.3
  • 5
    • 84856252354 scopus 로고    scopus 로고
    • Immune mechanisms of new therapeutic strategies in multiple sclerosis—A focus on alemtuzumab
    • Klotz, L.; Meuth, S.G.; Wiendl, H. Immune mechanisms of new therapeutic strategies in multiple sclerosis—A focus on alemtuzumab. Clin. Immunol. 2012, 142, 25–30.
    • (2012) Clin. Immunol , vol.142 , pp. 25-30
    • Klotz, L.1    Meuth, S.G.2    Wiendl, H.3
  • 7
    • 0032005642 scopus 로고    scopus 로고
    • Levels of expression of CD52 in normal and leukemic B and T cells: Correlation with in vivo therapeutic responses to Campath-1H
    • Ginaldi, L.; de Martinis, M.; Matutes, E.; Farahat, N.; Morilla, R.; Dyer, M.J.; Catovsky, D. Levels of expression of CD52 in normal and leukemic B and T cells: Correlation with in vivo therapeutic responses to Campath-1H. Leuk. Res. 1998, 22, 185–191.
    • (1998) Leuk. Res , vol.22 , pp. 185-191
    • Ginaldi, L.1    de Martinis, M.2    Matutes, E.3    Farahat, N.4    Morilla, R.5    Dyer, M.J.6    Catovsky, D.7
  • 8
    • 0034765991 scopus 로고    scopus 로고
    • The CD52 antigen and development of the Campath antibodies
    • Hale, G. The CD52 antigen and development of the Campath antibodies. Cytotherapy 2001, 3, 137–143.
    • (2001) Cytotherapy , vol.3 , pp. 137-143
    • Hale, G.1
  • 9
    • 0025878925 scopus 로고
    • Characterization of the Campath-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone
    • Xia, M.Q.; Tone, M.; Packman, L.; Hale, G.; Waldmann, H. Characterization of the Campath-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur. J. Immunol. 1991, 21, 1677–1684.
    • (1991) Eur. J. Immunol , vol.21 , pp. 1677-1684
    • Xia, M.Q.1    Tone, M.2    Packman, L.3    Hale, G.4    Waldmann, H.5
  • 10
    • 0028870425 scopus 로고
    • Cross-linking of the Campath-1 antigen (CD52) triggers activation of normal human T lymphocytes
    • Rowan, W.C.; Hale, G.; Tite, J.P.; Brett, S.J. Cross-linking of the Campath-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int. Immunol. 1995, 7, 69–77.
    • (1995) Int. Immunol , vol.7 , pp. 69-77
    • Rowan, W.C.1    Hale, G.2    Tite, J.P.3    Brett, S.J.4
  • 11
    • 0033559731 scopus 로고    scopus 로고
    • Characterization of the 4C8 antigen involved in transendothelial migration of CD26(Hi) T cells after tight adhesion to human umbilical vein endothelial cell monolayers
    • Masuyama, J.; Yoshio, T.; Suzuki, K.; Kitagawa, S.; Iwamoto, M.; Kamimura, T.; Hirata, D.; Takeda, A.; Kano, S.; Minota, S. Characterization of the 4C8 antigen involved in transendothelial migration of CD26(hi) T cells after tight adhesion to human umbilical vein endothelial cell monolayers. J. Exp. Med. 1999, 189, 979–990.
    • (1999) J. Exp. Med , vol.189 , pp. 979-990
    • Masuyama, J.1    Yoshio, T.2    Suzuki, K.3    Kitagawa, S.4    Iwamoto, M.5    Kamimura, T.6    Hirata, D.7    Takeda, A.8    Kano, S.9    Minota, S.10
  • 14
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K.J.; Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2001, 2, 816–822.
    • (2001) Nat. Immunol , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 15
    • 80052649553 scopus 로고    scopus 로고
    • CD4+FoxP3+ T regulatory cells in human autoimmunity: More than a numbers game
    • Long, S.A.; Buckner, J.H. CD4+FoxP3+ T regulatory cells in human autoimmunity: More than a numbers game. J. Immunol. 2011, 187, 2061–2066.
    • (2011) J. Immunol , vol.187 , pp. 2061-2066
    • Long, S.A.1    Buckner, J.H.2
  • 17
    • 84862677418 scopus 로고    scopus 로고
    • Human peripheral blood mononuclear cells exhibit heterogeneous CD52 expression levels and show differential sensitivity to alemtuzumab mediated cytolysis
    • Rao, S.P.; Sancho, J.; Campos-Rivera, J.; Boutin, P.M.; Severy, P.B.; Weeden, T.; Shankara, S.; Roberts, B.L.; Kaplan, J.M. Human peripheral blood mononuclear cells exhibit heterogeneous CD52 expression levels and show differential sensitivity to alemtuzumab mediated cytolysis. PLoS ONE 2012, 7, e39416.
    • (2012) Plos ONE , vol.7
    • Rao, S.P.1    Sancho, J.2    Campos-Rivera, J.3    Boutin, P.M.4    Severy, P.B.5    Weeden, T.6    Shankara, S.7    Roberts, B.L.8    Kaplan, J.M.9
  • 19
    • 84907260470 scopus 로고    scopus 로고
    • Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis: A review of its clinical pharmacology, efficacy and safety
    • Jones, D.E.; Goldman, M.D. Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis: A review of its clinical pharmacology, efficacy and safety. Expert Rev. Clin. Immunol. 2014, 10, 1281–1291.
    • (2014) Expert Rev. Clin. Immunol , vol.10 , pp. 1281-1291
    • Jones, D.E.1    Goldman, M.D.2
  • 21
    • 77249114139 scopus 로고    scopus 로고
    • B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis
    • Thompson, S.A.; Jones, J.L.; Cox, A.L.; Compston, D.A.; Coles, A.J. B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis. J. Clin. Immunol. 2010, 30, 99–105.
    • (2010) J. Clin. Immunol , vol.30 , pp. 99-105
    • Thompson, S.A.1    Jones, J.L.2    Cox, A.L.3    Compston, D.A.4    Coles, A.J.5
  • 22
    • 68849084141 scopus 로고    scopus 로고
    • IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)
    • Jones, J.L.; Phuah, C.L.; Cox, A.L.; Thompson, S.A.; Ban, M.; Shawcross, J.; Walton, A.; Sawcer, S.J.; Compston, A.; Coles, A.J. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J. Clin. Investig. 2009, 119, 2052–2061.
    • (2009) J. Clin. Investig , vol.119 , pp. 2052-2061
    • Jones, J.L.1    Phuah, C.L.2    Cox, A.L.3    Thompson, S.A.4    Ban, M.5    Shawcross, J.6    Walton, A.7    Sawcer, S.J.8    Compston, A.9    Coles, A.J.10
  • 25
    • 79952740129 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon β-1a in early relapsing-remitting multiple sclerosis: Post-hoc and subset analyses of clinical efficacy outcomes
    • Coles, A.J.; Fox, E.; Vladic, A.; Gazda, S.K.; Brinar, V.; Selmaj, K.W.; Bass, A.D.; Wynn, D.R.; Margolin, D.H.; Lake, S.L., et al. Alemtuzumab versus interferon β-1a in early relapsing-remitting multiple sclerosis: Post-hoc and subset analyses of clinical efficacy outcomes. Lancet Neurol. 2011, 10, 338–348.
    • (2011) Lancet Neurol , vol.10 , pp. 338-348
    • Coles, A.J.1    Fox, E.2    Vladic, A.3    Gazda, S.K.4    Brinar, V.5    Selmaj, K.W.6    Bass, A.D.7    Wynn, D.R.8    Margolin, D.H.9    Lake, S.L.10
  • 26
    • 84869492471 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon β 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled phase 3 trial
    • Cohen, J.A.; Coles, A.J.; Arnold, D.L.; Confavreux, C.; Fox, E.J.; Hartung, H.P.; Havrdova, E.; Selmaj, K.W.; Weiner, H.L.; Fisher, E., et al. Alemtuzumab versus interferon β 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled phase 3 trial. Lancet 2012, 380, 1819–1828.
    • (2012) Lancet , vol.380 , pp. 1819-1828
    • Cohen, J.A.1    Coles, A.J.2    Arnold, D.L.3    Confavreux, C.4    Fox, E.J.5    Hartung, H.P.6    Havrdova, E.7    Selmaj, K.W.8    Weiner, H.L.9    Fisher, E.10
  • 28
    • 84922924306 scopus 로고    scopus 로고
    • Alemtuzumab: A new therapy for active relapsing-remitting multiple sclerosis
    • Hartung, H.P.; Aktas, O.; Boyko, A.N. Alemtuzumab: A new therapy for active relapsing-remitting multiple sclerosis. Mult. Scler. 2015, 21, 22–34.
    • (2015) Mult. Scler , vol.21 , pp. 22-34
    • Hartung, H.P.1    Aktas, O.2    Boyko, A.N.3
  • 30
    • 84937476724 scopus 로고    scopus 로고
    • Durable effect of alemtuzumab on clinical outcomes in patients with relapsing-remitting multiple sclerosis who relapsed on prior therapy: 4-Year follow-up of CARE-MS II
    • Philadelphia, PA, USA, 26 April–3 May
    • Havrdova, E.; Giovannoni, G.; Arnold, D.L.; Coles, A.J.; Fox, E.J.; Hartung, H.; Selmaj, K.W.; Margolin, D.H.; Palmer, J.; Panzara, M., et al. Durable effect of alemtuzumab on clinical outcomes in patients with relapsing-remitting multiple sclerosis who relapsed on prior therapy: 4-Year follow-up of CARE-MS II. In Proceedings of the AAN Meeting, Philadelphia, PA, USA, 26 April–3 May 2014.
    • (2014) Proceedings of the AAN Meeting
    • Havrdova, E.1    Giovannoni, G.2    Arnold, D.L.3    Coles, A.J.4    Fox, E.J.5    Hartung, H.6    Selmaj, K.W.7    Margolin, D.H.8    Palmer, J.9    Panzara, M.10
  • 31
    • 84937476725 scopus 로고    scopus 로고
    • Durable effect of alemtuzumab on clinical outcomes in treatment-naive relapsing-remitting multiple sclerosis patients: 4-Year follow-up of CARE-MS I
    • Philadelphia, PA, USA, 26 April–3 May
    • Compston, D.A.S.; Giovannoni, G.; Arnold, D.L.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W; Margolin, D.H.; Palmer, J.; Panzara, M., et al. Durable effect of alemtuzumab on clinical outcomes in treatment-naive relapsing-remitting multiple sclerosis patients: 4-Year follow-up of CARE-MS I. In Proceedings of the AAN Meeting, Philadelphia, PA, USA, 26 April–3 May 2015.
    • (2015) Proceedings of the AAN Meeting
    • Compston, D.1    Giovannoni, G.2    Arnold, D.L.3    Fox, E.J.4    Hartung, H.5    Havrdova, E.6    Selmaj, K.W.7    Margolin, D.H.8    Palmer, J.9    Panzara, M.10
  • 32
    • 84937476726 scopus 로고    scopus 로고
    • Durable effect of alemtuzumab on disability improvement in patients with relapsing-remitting multiple sclerosis who relapsed on a prior therapy
    • Washington, DC, USA, 18–25 April
    • LaGanke, C.; Hughes, B.; Berkovich, R.; Cohen, J.A.; Giovannoni G.; Kasten, L.; Margolin, D.H.; Havrdova, E. Durable effect of alemtuzumab on disability improvement in patients with relapsing-remitting multiple sclerosis who relapsed on a prior therapy. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Laganke, C.1    Hughes, B.2    Berkovich, R.3    Cohen, J.A.4    Giovannoni, G.5    Kasten, L.6    Margolin, D.H.7    Havrdova, E.8
  • 33
    • 84937476727 scopus 로고    scopus 로고
    • Alemtuzumab slows brain volume loss over 4 years despite most relapsing-remitting multiple sclerosis patients not receiving treatment for 3 years
    • Washington, DC, USA, 18–25 April
    • Coles, A.J.; Arnold, D.L.; Cohen, J.A.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Kasten, L.; Panzara, M., et al. Alemtuzumab slows brain volume loss over 4 years despite most relapsing-remitting multiple sclerosis patients not receiving treatment for 3 years. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Coles, A.J.1    Arnold, D.L.2    Cohen, J.A.3    Fox, E.J.4    Hartung, H.5    Havrdova, E.6    Selmaj, K.W.7    Margolin, D.H.8    Kasten, L.9    Panzara, M.10
  • 34
    • 84937476728 scopus 로고    scopus 로고
    • Durable effect of alemtuzumab on MRI outcomes in patients with relapsing-remitting multiple sclerosis who relapsed on prior therapy: 4-Year follow-up of CARE-MS II
    • Washington, DC, USA, 18–25 April
    • Traboulsee, A.; Coles, A.J.; Cohen, J.A.; Compston, D.A.S.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Zhao, Y., et al. Durable effect of alemtuzumab on MRI outcomes in patients with relapsing-remitting multiple sclerosis who relapsed on prior therapy: 4-Year follow-up of CARE-MS II. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Traboulsee, A.1    Coles, A.J.2    Cohen, J.A.3    Compston, D.4    Fox, E.J.5    Hartung, H.6    Havrdova, E.7    Selmaj, K.W.8    Margolin, D.H.9    Zhao, Y.10
  • 35
    • 84937476729 scopus 로고    scopus 로고
    • Durable effect of alemtuzumab on MRI activity in treatment-naive active relapsing-remitting multiple sclerosis patients: 4-Year follow-up of CARE-MS I
    • Washington, DC, USA, 18–25 April
    • Arnold, D.L.; Traboulsee, A.; Coles, A.J.; Cohen, J.A.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Zhao, Y., et al. Durable effect of alemtuzumab on MRI activity in treatment-naive active relapsing-remitting multiple sclerosis patients: 4-Year follow-up of CARE-MS I. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Arnold, D.L.1    Traboulsee, A.2    Coles, A.J.3    Cohen, J.A.4    Fox, E.J.5    Hartung, H.6    Havrdova, E.7    Selmaj, K.W.8    Margolin, D.H.9    Zhao, Y.10
  • 36
    • 84937476730 scopus 로고    scopus 로고
    • Improvement in clinical outcomes in treatment-naive relapsing-remitting multiple sclerosis patients who switched from subcutaneous interferon β-1a to alemtuzumab
    • Washington, DC, USA, 18–25 April
    • Hartung, H.; Giovannoni, G.; Arnold, D.L.; Coles, A.J.; Fox, E.J.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Compston, D.A.S. Improvement in clinical outcomes in treatment-naive relapsing-remitting multiple sclerosis patients who switched from subcutaneous interferon β-1a to alemtuzumab. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Hartung, H.1    Giovannoni, G.2    Arnold, D.L.3    Coles, A.J.4    Fox, E.J.5    Havrdova, E.6    Selmaj, K.W.7    Margolin, D.H.8    Compston, D.9
  • 38
    • 84937476732 scopus 로고    scopus 로고
    • Switching to alemtuzumab from subcutaneous interferon β-1a after CARE-MS I further improved MRI outcomes in patients with relapsing-remitting multiple sclerosis
    • Washington, DC, USA, 18–25 April
    • Barkhof, F.; Pelletier, D.; Coles, A.J.; Cohen, J.A.; Compston, D.A.S.; Fox, E.J.; Hartung, H.; Havrdova, E.; Margolin, D.H.; Kasten, L., et al. Switching to alemtuzumab from subcutaneous interferon β-1a after CARE-MS I further improved MRI outcomes in patients with relapsing-remitting multiple sclerosis. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Barkhof, F.1    Pelletier, D.2    Coles, A.J.3    Cohen, J.A.4    Compston, D.5    Fox, E.J.6    Hartung, H.7    Havrdova, E.8    Margolin, D.H.9    Kasten, L.10
  • 39
    • 84937476733 scopus 로고    scopus 로고
    • Switching to alemtuzumab from subcutaneous interferon β-1a after CARE-MS II further improved MRI outcomes in patients with relapsing-remitting multiple sclerosis
    • Washington, DC, USA, 18–25 April
    • Pelletier, D.; Barkhof, F.; Coles, A.J.; Cohen, J.A.; Compston, D.A.S.; Fox, E.J.; Hartung, H.; Havrdova, E.; Margolin, D.H.; Kasten, L., et al. Switching to alemtuzumab from subcutaneous interferon β-1a after CARE-MS II further improved MRI outcomes in patients with relapsing-remitting multiple sclerosis. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Pelletier, D.1    Barkhof, F.2    Coles, A.J.3    Cohen, J.A.4    Compston, D.5    Fox, E.J.6    Hartung, H.7    Havrdova, E.8    Margolin, D.H.9    Kasten, L.10
  • 40
    • 84937476734 scopus 로고    scopus 로고
    • Slowing of brain volume loss in patients with relapsing-remitting multiple sclerosis after switching from subcutaneous interferon β-1a to alemtuzumab
    • Washington, DC, USA, 18–25 April
    • Cohen, J.A.; Arnold, D.L.; Coles, A.J.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Kasten, L.; Compston, D.A.S. Slowing of brain volume loss in patients with relapsing-remitting multiple sclerosis after switching from subcutaneous interferon β-1a to alemtuzumab. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Cohen, J.A.1    Arnold, D.L.2    Coles, A.J.3    Fox, E.J.4    Hartung, H.5    Havrdova, E.6    Selmaj, K.W.7    Margolin, D.H.8    Kasten, L.9    Compston, D.10
  • 41
    • 34248531422 scopus 로고    scopus 로고
    • Cytokine-release syndrome: Overview and nursing implications
    • Breslin, S. Cytokine-release syndrome: Overview and nursing implications. Clin. J. Oncol. Nurs. 2007, 11, 37–42.
    • (2007) Clin. J. Oncol. Nurs , vol.11 , pp. 37-42
    • Breslin, S.1
  • 42
    • 78650578346 scopus 로고    scopus 로고
    • Acute infusion reactions induced by monoclonal antibody therapy
    • Maggi, E.; Vultaggio, A.; Matucci, A. Acute infusion reactions induced by monoclonal antibody therapy. Expert Rev. Clin. Immunol. 2011, 7, 55–63.
    • (2011) Expert Rev. Clin. Immunol , vol.7 , pp. 55-63
    • Maggi, E.1    Vultaggio, A.2    Matucci, A.3
  • 44
    • 84937476735 scopus 로고    scopus 로고
    • Administration of alemtuzumab on nonconsecutive days does not impact infusion-associated reactions, efficacy, or lymphocyte depletion
    • Washington, DC, USA, 18–25 April
    • Wray, S.; Boyko, A.N.; Braley, T.J.; Khan, O.; Margolin, D.H.; Coles, A.J. Administration of alemtuzumab on nonconsecutive days does not impact infusion-associated reactions, efficacy, or lymphocyte depletion. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Wray, S.1    Boyko, A.N.2    Braley, T.J.3    Khan, O.4    Margolin, D.H.5    Coles, A.J.6
  • 47
    • 84937476738 scopus 로고    scopus 로고
    • Incidence of infection decreases over time in alemtuzumab-treated patients with relapsing-remitting multiple sclerosis: 4-year follow-up of the CARE-MS studies
    • Washington, DC, USA, 18–25 April
    • Henson, L.J.; Arnold, D.L.; Cohen, J.A.; Coles, A.J.; Fox, E.J.; Hartung, H.; Havrdova, E.; Selmaj, K.W.; Margolin, D.H.; Compston, D.A.S. Incidence of infection decreases over time in alemtuzumab-treated patients with relapsing-remitting multiple sclerosis: 4-year follow-up of the CARE-MS studies. In Proceedings of the AAN Meeting, Washington, DC, USA, 18–25 April 2015.
    • (2015) Proceedings of the AAN Meeting
    • Henson, L.J.1    Arnold, D.L.2    Cohen, J.A.3    Coles, A.J.4    Fox, E.J.5    Hartung, H.6    Havrdova, E.7    Selmaj, K.W.8    Margolin, D.H.9    Compston, D.10
  • 51
    • 84993707958 scopus 로고    scopus 로고
    • Analysis of data from rrms alemtuzumab-treated patients in the clinical program to evaluate incidence rates of malignancy
    • Boston, MA, USA, 10–13 September
    • Miller, T.; Habek, M.; Coles, A.; Selmaj, K.; Margolin, D.; Palmer, J. Analysis of data from rrms alemtuzumab-treated patients in the clinical program to evaluate incidence rates of malignancy. In Proceedings of the Join ACTRIMS-ECTRIMS Meeting, Boston, MA, USA, 10–13 September 2014.
    • (2014) Proceedings of the Join ACTRIMS-ECTRIMS Meeting
    • Miller, T.1    Habek, M.2    Coles, A.3    Selmaj, K.4    Margolin, D.5    Palmer, J.6
  • 52
    • 84937476740 scopus 로고    scopus 로고
    • accessed on 4 May
    • Alemtuzumab prescribing information. Available online: http://www.Accessdata.Fda.Gov/drugsatfda_docs/label/2014/103948s5139lbl.Pdf (accessed on 4 May 2015).
    • (2015)
  • 58
    • 33746189876 scopus 로고    scopus 로고
    • Autoimmunity during lymphopenia: A two-hit model
    • Krupica, T., Jr.; Fry, T.J.; Mackall, C.L. Autoimmunity during lymphopenia: A two-hit model. Clin. Immunol. 2006, 120, 121–128.
    • (2006) Clin. Immunol , vol.120 , pp. 121-128
    • Krupica, T.1    Fry, T.J.2    Mackall, C.L.3
  • 60
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie, F.; Leach, M.W.; Mauze, S.; Caddle, L.B.; Coffman, R.L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 1993, 5, 1461–1471.
    • (1993) Int. Immunol , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 63
    • 45949090105 scopus 로고    scopus 로고
    • Release from regulatory T Cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21
    • Clough, L.E.; Wang, C.J.; Schmidt, E.M.; Booth, G.; Hou, T.Z.; Ryan, G.A.; Walker, L.S. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 2008, 180, 5393–5401.
    • (2008) J. Immunol , vol.180 , pp. 5393-5401
    • Clough, L.E.1    Wang, C.J.2    Schmidt, E.M.3    Booth, G.4    Hou, T.Z.5    Ryan, G.A.6    Walker, L.S.7
  • 65
    • 3843124199 scopus 로고    scopus 로고
    • Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function
    • Chu, Y.W.; Memon, S.A.; Sharrow, S.O.; Hakim, F.T.; Eckhaus, M.; Lucas, P.J.; Gress, R.E. Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function. Blood 2004, 104, 1110–1119.
    • (2004) Blood , vol.104 , pp. 1110-1119
    • Chu, Y.W.1    Memon, S.A.2    Sharrow, S.O.3    Hakim, F.T.4    Eckhaus, M.5    Lucas, P.J.6    Gress, R.E.7
  • 66
    • 84937476744 scopus 로고    scopus 로고
    • Predicting autoimmunity following treatment of multiple sclerosis with alemtuzumab
    • Amsterdam, The Netherlands, 19–22 October
    • Jones, J.L.; Compston, D.A.S.; Coles, A.J. Predicting autoimmunity following treatment of multiple sclerosis with alemtuzumab. In Proceedings of the ECTRIMS Meeting, Amsterdam, The Netherlands, 19–22 October 2011.
    • (2011) Proceedings of the ECTRIMS Meeting
    • Jones, J.L.1    Compston, D.2    Coles, A.J.3
  • 67
    • 0034023587 scopus 로고    scopus 로고
    • Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey
    • Broadley, S.A.; Deans, J.; Sawcer, S.J.; Clayton, D.; Compston, D.A. Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey. Brain 2000, 123 Pt 6, 1102–1111.
    • (2000) Brain , vol.123 , pp. 1102-1111
    • Broadley, S.A.1    Deans, J.2    Sawcer, S.J.3    Clayton, D.4    Compston, D.A.5
  • 68
    • 49449108196 scopus 로고    scopus 로고
    • Anti-glomerular basement membrane disease after alemtuzumab
    • Clatworthy, M.R.; Wallin, E.F.; Jayne, D.R. Anti-glomerular basement membrane disease after alemtuzumab. N. Engl. J. Med. 2008, 359, 768–769.
    • (2008) N. Engl. J. Med , vol.359 , pp. 768-769
    • Clatworthy, M.R.1    Wallin, E.F.2    Jayne, D.R.3
  • 71
    • 71649083353 scopus 로고    scopus 로고
    • Clustering and commonalities among autoimmune diseases
    • Mackay, I.R. Clustering and commonalities among autoimmune diseases. J. Autoimmun. 2009, 33, 170–177.
    • (2009) J. Autoimmun , vol.33 , pp. 170-177
    • Mackay, I.R.1
  • 73
    • 40449101381 scopus 로고    scopus 로고
    • CD4+CD25+FoxP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H
    • Bloom, D.D.; Chang, Z.; Fechner, J.H.; Dar, W.; Polster, S.P.; Pascual, J.; Turka, L.A.; Knechtle, S.J. CD4+CD25+FoxP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am. J. Transplant. 2008, 8, 793–802.
    • (2008) Am. J. Transplant , vol.8 , pp. 793-802
    • Bloom, D.D.1    Chang, Z.2    Fechner, J.H.3    Dar, W.4    Polster, S.P.5    Pascual, J.6    Turka, L.A.7    Knechtle, S.J.8
  • 74
    • 77957044257 scopus 로고    scopus 로고
    • Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity
    • Jones, J.L.; Anderson, J.M.; Phuah, C.L.; Fox, E.J.; Selmaj, K.; Margolin, D.; Lake, S.L.; Palmer, J.; Thompson, S.J.; Wilkins, A., et al. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain 2010, 133, 2232–2247.
    • (2010) Brain , vol.133 , pp. 2232-2247
    • Jones, J.L.1    Anderson, J.M.2    Phuah, C.L.3    Fox, E.J.4    Selmaj, K.5    Margolin, D.6    Lake, S.L.7    Palmer, J.8    Thompson, S.J.9    Wilkins, A.10
  • 75
    • 84890400796 scopus 로고    scopus 로고
    • Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (Anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis
    • Zhang, X.; Tao, Y.; Chopra, M.; Ahn, M.; Marcus, K.L.; Choudhary, N.; Zhu, H.; Markovic-Plese, S. Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. J. Immunol. 2013, 191, 5867–5874.
    • (2013) J. Immunol , vol.191 , pp. 5867-5874
    • Zhang, X.1    Tao, Y.2    Chopra, M.3    Ahn, M.4    Marcus, K.L.5    Choudhary, N.6    Zhu, H.7    Markovic-Plese, S.8
  • 76
    • 47049100425 scopus 로고    scopus 로고
    • Activation of myelin reactive t cells in multiple sclerosis: A possible role for t cell degeneracy?
    • Stinissen, P.; Hellings, N. Activation of myelin reactive t cells in multiple sclerosis: A possible role for t cell degeneracy? Eur. J. Immunol. 2008, 38, 1190–1193.
    • (2008) Eur. J. Immunol , vol.38 , pp. 1190-1193
    • Stinissen, P.1    Hellings, N.2
  • 79
    • 84922588873 scopus 로고    scopus 로고
    • Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis
    • Wang, H.; Dong, J.; Shi, P.; Liu, J.; Zuo, L.; Li, Y.; Gong, J.; Gu, L.; Zhao, J.; Zhang, L., et al. Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis. Immunology 2015, 144, 254–262.
    • (2015) Immunology , vol.144 , pp. 254-262
    • Wang, H.1    Dong, J.2    Shi, P.3    Liu, J.4    Zuo, L.5    Li, Y.6    Gong, J.7    Gu, L.8    Zhao, J.9    Zhang, L.10
  • 81
    • 84937398076 scopus 로고    scopus 로고
    • Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis
    • Turner, M.; Pang, P.T.; Chretien, N.; Havari, E.; LaMorte, M.J.; Oliver, J.; Pande, N.; Masterjohn, E.; Carter, K.; Reczek, D., et al. Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2015, 285, 4–12.
    • (2015) J. Neuroimmunol , vol.285 , pp. 4-12
    • Turner, M.1    Pang, P.T.2    Chretien, N.3    Havari, E.4    Lamorte, M.J.5    Oliver, J.6    Pande, N.7    Masterjohn, E.8    Carter, K.9    Reczek, D.10
  • 82
    • 11144221749 scopus 로고    scopus 로고
    • The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
    • Baccala, R.; Theofilopoulos, A.N. The new paradigm of T-cell homeostatic proliferation-induced autoimmunity. Trends Immunol. 2005, 26, 5–8.
    • (2005) Trends Immunol , vol.26 , pp. 5-8
    • Baccala, R.1    Theofilopoulos, A.N.2
  • 83
    • 0037460071 scopus 로고    scopus 로고
    • Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells
    • Kassiotis, G.; Zamoyska, R.; Stockinger, B. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J. Exp. Med. 2003, 197, 1007–1016.
    • (2003) J. Exp. Med , vol.197 , pp. 1007-1016
    • Kassiotis, G.1    Zamoyska, R.2    Stockinger, B.3
  • 85
    • 84881096188 scopus 로고    scopus 로고
    • Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system
    • Sinclair, C.; Bains, I.; Yates, A.J.; Seddon, B. Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc. Natl. Acad. Sci. USA 2013, 110, E2905–2914.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E2905-E2914
    • Sinclair, C.1    Bains, I.2    Yates, A.J.3    Seddon, B.4
  • 86
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 Years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold, R.; Linington, C.; Lassmann, H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 Years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 2006, 129, 1953–1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 87
  • 88
    • 84982234400 scopus 로고    scopus 로고
    • Secondary progression and innate immunity in nmo: A possible link to alemtuzumab therapy? Neurol. Neuroimmunol
    • Fujihara, K.; Nakashima, I. Secondary progression and innate immunity in nmo: A possible link to alemtuzumab therapy? Neurol. Neuroimmunol. Neuroinflammation 2014, 1, e38.
    • (2014) Neuroinflammation , vol.1
    • Fujihara, K.1    Nakashima, I.2
  • 89
    • 84948185953 scopus 로고    scopus 로고
    • Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with nmo. Neurol. Neuroimmunol
    • Gelfand, J.M.; Cotter, J.; Klingman, J.; Huang, E.J.; Cree, B.A. Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with nmo. Neurol. Neuroimmunol. Neuroinflammation 2014, 1, e34.
    • (2014) Neuroinflammation , vol.1
    • Gelfand, J.M.1    Cotter, J.2    Klingman, J.3    Huang, E.J.4    Cree, B.A.5
  • 90
    • 0035693963 scopus 로고    scopus 로고
    • Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations
    • Thorne, R.G.; Frey, W.H. 2nd. Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations. Clin. Pharmacokinet. 2001, 40, 907–946.
    • (2001) Clin. Pharmacokinet , vol.40 , pp. 907-946
    • Thorne, R.G.1    Frey, W.H.2
  • 91
    • 84903985522 scopus 로고    scopus 로고
    • Accelerated lymphocyte recovery after alemtuzumab does not predict multiple sclerosis activity
    • Kousin-Ezewu, O.; Azzopardi, L.; Parker, R.A.; Tuohy, O.; Compston, A.; Coles, A.; Jones, J. Accelerated lymphocyte recovery after alemtuzumab does not predict multiple sclerosis activity. Neurology 2014, 82, 2158–2164.
    • (2014) Neurology , vol.82 , pp. 2158-2164
    • Kousin-Ezewu, O.1    Azzopardi, L.2    Parker, R.A.3    Tuohy, O.4    Compston, A.5    Coles, A.6    Jones, J.7
  • 95
    • 84914173724 scopus 로고    scopus 로고
    • No evidence of disease activity: Indirect comparisons of oral therapies for the treatment of relapsing-remitting multiple sclerosis
    • Nixon, R.; Bergvall, N.; Tomic, D.; Sfikas, N.; Cutter, G.; Giovannoni, G. No evidence of disease activity: Indirect comparisons of oral therapies for the treatment of relapsing-remitting multiple sclerosis. Adv. Ther. 2014, 31, 1134–1154.
    • (2014) Adv. Ther , vol.31 , pp. 1134-1154
    • Nixon, R.1    Bergvall, N.2    Tomic, D.3    Sfikas, N.4    Cutter, G.5    Giovannoni, G.6
  • 96
    • 84937476749 scopus 로고    scopus 로고
    • Fingolimod treatment increases the proportion of patients who are free from disease activity in multiple sclerosis compared to IFNβ-1a: Results from a phase 3, active-controlled study (transforms)
    • New Orleans, LA, USA, 23 April
    • Khatri, B.; Barkhof, F.; Comi, G.; Jin, J.; Francis, G.; Cohen, J. Fingolimod treatment increases the proportion of patients who are free from disease activity in multiple sclerosis compared to IFNβ-1a: Results from a phase 3, active-controlled study (transforms). In Proceedings of the AAN Meeting, New Orleans, LA, USA, 23 April 2012.
    • (2012) Proceedings of the AAN Meeting
    • Khatri, B.1    Barkhof, F.2    Comi, G.3    Jin, J.4    Francis, G.5    Cohen, J.6
  • 98
    • 60049089535 scopus 로고    scopus 로고
    • Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the natalizumab safety and efficacy in relapsing-remitting multiple sclerosis (affirm) study
    • Havrdova, E.; Galetta, S.; Hutchinson, M.; Stefoski, D.; Bates, D.; Polman, C.H.; O'Connor, P.W.; Giovannoni, G.; Phillips, J.T.; Lublin, F.D., et al. Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the natalizumab safety and efficacy in relapsing-remitting multiple sclerosis (affirm) study. Lancet Neurol. 2009, 8, 254–260.
    • (2009) Lancet Neurol , vol.8 , pp. 254-260
    • Havrdova, E.1    Galetta, S.2    Hutchinson, M.3    Stefoski, D.4    Bates, D.5    Polman, C.H.6    O'connor, P.W.7    Giovannoni, G.8    Phillips, J.T.9    Lublin, F.D.10
  • 101
    • 84937476750 scopus 로고    scopus 로고
    • Safety of using disease-modifying therapy post-alemtuzumab treatment in patients with relapsing-remitting multiple sclerosis in the core and extensions phases of CAMMS223, CARE-MS I, and CARE-MS II studies
    • Philadelphia, PA, USA, 26 April–3 May
    • Edwards, K.; LaGanke, C.; Oyuela, P.; Palmer, J.; Margolin, D. Safety of using disease-modifying therapy post-alemtuzumab treatment in patients with relapsing-remitting multiple sclerosis in the core and extensions phases of CAMMS223, CARE-MS I, and CARE-MS II studies. In Proceedings of the AAN Meeting, Philadelphia, PA, USA, 26 April–3 May 2015.
    • (2015) Proceedings of the AAN Meeting
    • Edwards, K.1    Laganke, C.2    Oyuela, P.3    Palmer, J.4    Margolin, D.5


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