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Volumn 187, Issue 5, 2011, Pages 2061-2066

CD4+FOXP3+ T regulatory cells in human autoimmunity: More than a numbers game

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD45RA ANTIGEN; CD45RO ANTIGEN; CORTICOSTEROID; DACLIZUMAB; GLATIRAMER; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 80052649553     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003224     Document Type: Short Survey
Times cited : (243)

References (104)
  • 3
    • 35348876040 scopus 로고    scopus 로고
    • IPEX, FOXP3 and regulatory T-cells: A model for autoimmunity
    • DOI 10.1007/s12026-007-0022-2
    • Ochs, H. D., E. Gambineri, and T. R. Torgerson. 2007. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol. Res. 38: 112-121. (Pubitemid 47574902)
    • (2007) Immunologic Research , vol.38 , Issue.1-3 , pp. 112-121
    • Ochs, H.D.1    Gambineri, E.2    Torgerson, T.R.3
  • 5
    • 0037099733 scopus 로고    scopus 로고
    • + regulatory, contact-dependent T cells induce interleukin 1-producing, contact-independent type 1-like regulatory T cells
    • DOI 10.1084/jem.20020642
    • Dieckmann, D., C. H. Bruett, H. Ploettner, M. B. Lutz, and G. Schuler. 2002. Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J. Exp. Med. 196: 247-253. (Pubitemid 34787514)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.2 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 6
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+) CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens, L. A., C. Mottet, D. Mason, and F. Powrie. 2001. Human CD4(+) CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31: 1247-1254.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 7
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • DOI 10.1038/ni1179
    • Fontenot, J. D., and A. Y. Rudensky. 2005. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6: 331-337. (Pubitemid 41716769)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 8
    • 17844364504 scopus 로고    scopus 로고
    • + T-cells in type 1 diabetes
    • DOI 10.2337/diabetes.54.5.1407
    • Brusko, T. M., C. H. Wasserfall, M. J. Clare-Salzler, D. A. Schatz, and M. A. Atkinson. 2005. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 54: 1407-1414. (Pubitemid 40586671)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Atkinson, M.A.5
  • 9
    • 0037261145 scopus 로고    scopus 로고
    • + T cells from the target organ of patients with rheumatoid arthritis
    • DOI 10.1002/immu.200390024
    • Cao, D., V. Malmström, C. Baecher-Allan, D. Hafler, L. Klareskog, and C. Trollmo. 2003. Isolation and functional characterization of regulatory CD25 bright CD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33: 215-223. (Pubitemid 36157659)
    • (2003) European Journal of Immunology , vol.33 , Issue.1 , pp. 215-223
    • Cao, D.1    Malmstrom, V.2    Baecher-Allan, C.3    Hafler, D.4    Klareskog, L.5    Trollmo, C.6
  • 10
    • 33846817153 scopus 로고    scopus 로고
    • + regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
    • DOI 10.1111/j.1365-2249.2006.03271.x
    • Feger, U., C. Luther, S. Poeschel, A. Melms, E. Tolosa, and H. Wiendl. 2007. Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin. Exp. Immunol. 147: 412-418. (Pubitemid 46208041)
    • (2007) Clinical and Experimental Immunology , vol.147 , Issue.3 , pp. 412-418
    • Feger, U.1    Luther, C.2    Poeschel, S.3    Melms, A.4    Tolosa, E.5    Wiendl, H.6
  • 12
    • 12144249838 scopus 로고    scopus 로고
    • + T-cells from patients with type 1 diabetes
    • DOI 10.2337/diabetes.54.1.92
    • Lindley, S., C. M. Dayan, A. Bishop, B. O. Roep, M. Peakman, and T. I. Tree. 2005. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54: 92-99. (Pubitemid 40105099)
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peatman, M.5    Tree, T.I.M.6
  • 13
    • 17644384896 scopus 로고    scopus 로고
    • + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • DOI 10.1111/j.1365-2249.2005.02754.x
    • Möttönen, M., J. Heikkinen, L. Mustonen, P. Isomäki, R. Luukkainen, and O. Lassila. 2005. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol. 140: 360-367. (Pubitemid 40559165)
    • (2005) Clinical and Experimental Immunology , vol.140 , Issue.2 , pp. 360-367
    • Mottonen, M.1    Heikkinen, J.2    Mustonen, L.3    Isomaki, P.4    Luukkainen, R.5    Lassila, O.6
  • 14
    • 1842607712 scopus 로고    scopus 로고
    • + T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    • DOI 10.1023/B:JOCI.0000019780.93817.82
    • Putheti, P., A. Pettersson, M. Soderstrom, H. Link, and Y. M. Huang. 2004. Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs. J. Clin. Immunol. 24: 155-161. (Pubitemid 38457229)
    • (2004) Journal of Clinical Immunology , vol.24 , Issue.2 , pp. 155-161
    • Putheti, P.1    Pettersson, A.2    Soderstrom, M.3    Link, H.4    Huang, Y.M.5
  • 15
    • 13944270218 scopus 로고    scopus 로고
    • high regulatory T cells in human autoimmune diabetes
    • DOI 10.1016/j.jaut.2004.11.004
    • Putnam, A. L., F. Vendrame, F. Dotta, and P. A. Gottlieb. 2005. CD4+CD25high regulatory T cells in human autoimmune diabetes. J. Autoimmun. 24: 55-62. (Pubitemid 40269495)
    • (2005) Journal of Autoimmunity , vol.24 , Issue.1 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 16
    • 1842732224 scopus 로고    scopus 로고
    • + Regulatory T Cells in Patients with Multiple Sclerosis
    • DOI 10.1084/jem.20031579
    • Viglietta, V., C. Baecher-Allan, H. L. Weiner, and D. A. Hafler. 2004. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199: 971-979. (Pubitemid 38481088)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.7 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 18
    • 44449171488 scopus 로고    scopus 로고
    • Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: Recovery of memory Treg homeostasis during disease progression
    • Venken, K., N. Hellings, T. Broekmans, K. Hensen, J. L. Rummens, and P. Stinissen. 2008. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 180: 6411-6420.
    • (2008) J. Immunol. , vol.180 , pp. 6411-6420
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.L.5    Stinissen, P.6
  • 19
    • 51449116424 scopus 로고    scopus 로고
    • CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
    • Han, G. M., N. J. O'Neil-Andersen, R. B. Zurier, and D. A. Lawrence. 2008. CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell. Immunol. 253: 92-101.
    • (2008) Cell. Immunol. , vol.253 , pp. 92-101
    • Han, G.M.1    O'Neil-Andersen, N.J.2    Zurier, R.B.3    Lawrence, D.A.4
  • 22
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • DOI 10.1016/S0896-8411(03)00121-5
    • Crispin, J. C., A. Martínez, and J. Alcocer-Varela. 2003. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J. Autoimmun. 21: 273-276. (Pubitemid 37410115)
    • (2003) Journal of Autoimmunity , vol.21 , Issue.3 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 23
    • 33645051462 scopus 로고    scopus 로고
    • Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus
    • Lee, J. H., L. C. Wang, Y. T. Lin, Y. H. Yang, D. T. Lin, and B. L. Chiang. 2006. Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology 117: 280-286.
    • (2006) Immunology , vol.117 , pp. 280-286
    • Lee, J.H.1    Wang, L.C.2    Lin, Y.T.3    Yang, Y.H.4    Lin, D.T.5    Chiang, B.L.6
  • 26
    • 65449149735 scopus 로고    scopus 로고
    • Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus
    • Suen, J. L., H. T. Li, Y. J. Jong, B. L. Chiang, and J. H. Yen. 2009. Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology 127: 196-205.
    • (2009) Immunology , vol.127 , pp. 196-205
    • Suen, J.L.1    Li, H.T.2    Jong, Y.J.3    Chiang, B.L.4    Yen, J.H.5
  • 29
    • 33846340789 scopus 로고    scopus 로고
    • FOXP3: Not just for regulatory T cells anymore
    • DOI 10.1002/eji.200636929
    • Ziegler, S. F. 2007. FOXP3: not just for regulatory T cells anymore. Eur. J. Immunol. 37: 21-23. (Pubitemid 46128782)
    • (2007) European Journal of Immunology , vol.37 , Issue.1 , pp. 21-23
    • Ziegler, S.F.1
  • 30
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, A. M., P. E. Korty, D. Q. Tran, E. A. Wohlfert, P. E. Murray, Y. Belkaid, and E. M. Shevach. 2010. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184: 3433-3441.
    • (2010) J. Immunol. , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6    Shevach, E.M.7
  • 31
    • 20444434616 scopus 로고    scopus 로고
    • high T cells in inflammatory bowel disease
    • DOI 10.1053/j.gastro.2005.03.043, PII S0016508505005664
    • Maul, J., C. Loddenkemper, P. Mundt, E. Berg, T. Giese, A. Stallmach, M. Zeitz, and R. Duchmann. 2005. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 128: 1868-1878. (Pubitemid 40824698)
    • (2005) Gastroenterology , vol.128 , Issue.7 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3    Berg, E.4    Giese, T.5    Stallmach, A.6    Zeitz, M.7    Duchmann, R.8
  • 34
    • 33751231701 scopus 로고    scopus 로고
    • + regulatory T cells: Current controversies and future perspectives
    • DOI 10.1002/eji.200636459
    • Banham, A. H., F. M. Powrie, and E. Suri-Payer. 2006. FOXP3+ regulatory T cells: current controversies and future perspectives. Eur. J. Immunol. 36: 2832-2836. (Pubitemid 44782555)
    • (2006) European Journal of Immunology , vol.36 , Issue.11 , pp. 2832-2836
    • Banham, A.H.1    Powrie, F.M.2    Suri-Payer, E.3
  • 35
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell, D. J., and M. A. Koch. 2011. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11: 119-130.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 36
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • DOI 10.1038/nri1032
    • Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3: 253-257. (Pubitemid 37323210)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 37
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas, J., B. Fritzsching, P. Trübswetter, M. Korporal, L.Milkova, B. Fritz, D. Vobis, P. H. Krammer, E. Suri-Payer, and B. Wildemann. 2007. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J. Immunol. 179: 1322-1330.
    • (2007) J. Immunol. , vol.179 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trübswetter, P.3    Korporal, M.4    Milkova, L.5    Fritz, B.6    Vobis, D.7    Krammer, P.H.8    Suri-Payer, E.9    Wildemann, B.10
  • 38
    • 77952754636 scopus 로고    scopus 로고
    • Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO
    • Booth, N. J., A. J. McQuaid, T. Sobande, S. Kissane, E. Agius, S. E. Jackson, M. Salmon, F. Falciani, K. Yong, M. H. Rustin, et al. 2010. Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J. Immunol. 184: 4317-4326.
    • (2010) J. Immunol. , vol.184 , pp. 4317-4326
    • Booth, N.J.1    McQuaid, A.J.2    Sobande, T.3    Kissane, S.4    Agius, E.5    Jackson, S.E.6    Salmon, M.7    Falciani, F.8    Yong, K.9    Rustin, M.H.10
  • 39
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara, M., Y. Yoshioka, A. Kitoh, T. Shima, K. Wing, A. Niwa, C. Parizot, C. Taflin, T. Heike, D. Valeyre, et al. 2009. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5    Niwa, A.6    Parizot, C.7    Taflin, C.8    Heike, T.9    Valeyre, D.10
  • 41
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn, J., J. K. Polansky, and A. Hamann. 2009. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat. Rev. Immunol. 9: 83-89.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 42
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
    • Curotto de Lafaille, M. A., and J. J. Lafaille. 2009. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30: 626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 43
    • 79954998783 scopus 로고    scopus 로고
    • Cutting edge: De novo induction of functional foxp3+ regulatory CD4 T cells in response to tissue-restricted self antigen
    • Thompson, L. J., A. C. Valladao, and S. F. Ziegler. 2011. Cutting edge: de novo induction of functional foxp3+ regulatory CD4 T cells in response to tissue-restricted self antigen. J. Immunol. 186: 4551-4555.
    • (2011) J. Immunol. , vol.186 , pp. 4551-4555
    • Thompson, L.J.1    Valladao, A.C.2    Ziegler, S.F.3
  • 44
    • 33846923124 scopus 로고    scopus 로고
    • + regulatory T cells and for expansion of these cells
    • Zheng, S. G., J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz. 2007. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol. 178: 2018-2027. (Pubitemid 46233398)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2018-2027
    • Song, G.Z.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 46
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider, A., M. Rieck, S. Sanda, C. Pihoker, C. Greenbaum, and J. H. Buckner. 2008. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J. Immunol. 181: 7350-7355.
    • (2008) J. Immunol. , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5    Buckner, J.H.6
  • 47
    • 58149459511 scopus 로고    scopus 로고
    • Transcriptional regulation of IL-2 in health and autoimmunity
    • Crispín, J. C., and G. C. Tsokos. 2009. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun. Rev. 8: 190-195.
    • (2009) Autoimmun. Rev. , vol.8 , pp. 190-195
    • Crispín, J.C.1    Tsokos, G.C.2
  • 49
    • 70149120971 scopus 로고    scopus 로고
    • Intact extracellular matrix and the maintenance of immune tolerance: High molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
    • Bollyky, P. L., B. A. Falk, R. P. Wu, J. H. Buckner, T. N. Wight, and G. T. Nepom. 2009. Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 86: 567-572.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 567-572
    • Bollyky, P.L.1    Falk, B.A.2    Wu, R.P.3    Buckner, J.H.4    Wight, T.N.5    Nepom, G.T.6
  • 50
    • 84926109500 scopus 로고    scopus 로고
    • TNF-alpha: An activator of CD4+FoxP3+ TNFR2+ regulatory T cells
    • Chen, X., and J. J. Oppenheim. 2010. TNF-alpha: an activator of CD4+FoxP3+ TNFR2+ regulatory T cells. Curr. Dir. Autoimmun. 11: 119-134.
    • (2010) Curr. Dir. Autoimmun. , vol.11 , pp. 119-134
    • Chen, X.1    Oppenheim, J.J.2
  • 51
    • 77954503874 scopus 로고    scopus 로고
    • Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands
    • Oberg, H. H., T. T. Ly, S. Ussat, T. Meyer, D. Kabelitz, and D. Wesch. 2010. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J. Immunol. 184: 4733-4740.
    • (2010) J. Immunol. , vol.184 , pp. 4733-4740
    • Oberg, H.H.1    Ly, T.T.2    Ussat, S.3    Meyer, T.4    Kabelitz, D.5    Wesch, D.6
  • 52
    • 77956894327 scopus 로고    scopus 로고
    • Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function
    • Tanaka, S., S. Maeda, M. Hashimoto, C. Fujimori, Y. Ito, S. Teradaira, K. Hirota, H. Yoshitomi, T. Katakai, A. Shimizu, et al. 2010. Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J. Immunol. 185: 2295-2305.
    • (2010) J. Immunol. , vol.185 , pp. 2295-2305
    • Tanaka, S.1    Maeda, S.2    Hashimoto, M.3    Fujimori, C.4    Ito, Y.5    Teradaira, S.6    Hirota, K.7    Yoshitomi, H.8    Katakai, T.9    Shimizu, A.10
  • 56
    • 78649897032 scopus 로고    scopus 로고
    • Human regulatory T cells in autoimmune diseases
    • Cvetanovich, G. L., and D. A. Hafler. 2010. Human regulatory T cells in autoimmune diseases. Curr. Opin. Immunol. 22: 753-760.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 753-760
    • Cvetanovich, G.L.1    Hafler, D.A.2
  • 58
    • 33751227462 scopus 로고    scopus 로고
    • Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals
    • DOI 10.1016/j.jns.2006.09.006, PII S0022510X06003856
    • Fritzsching, B., M. Korporal, J. Haas, P. H. Krammer, E. Suri-Payer, and B. Wildemann. 2006. Similar sensitivity of regulatory T cells towards CD95L-mediated apoptosis in patients with multiple sclerosis and healthy individuals. J. Neurol. Sci. 251: 91-97. (Pubitemid 44792146)
    • (2006) Journal of the Neurological Sciences , vol.251 , Issue.1-2 , pp. 91-97
    • Fritzsching, B.1    Korporal, M.2    Haas, J.3    Krammer, P.H.4    Suri-Payer, E.5    Wildemann, B.6
  • 62
    • 55849126729 scopus 로고    scopus 로고
    • Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
    • Michel, L., L. Berthelot, S. Pettré, S. Wiertlewski, F. Lefrère, C. Braudeau, S. Brouard, J. P. Soulillou, and D. A. Laplaud. 2008. Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J. Clin. Invest. 118: 3411-3419.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3411-3419
    • Michel, L.1    Berthelot, L.2    Pettré, S.3    Wiertlewski, S.4    Lefrère, F.5    Braudeau, C.6    Brouard, S.7    Soulillou, J.P.8    Laplaud, D.A.9
  • 64
    • 55449111318 scopus 로고    scopus 로고
    • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • Lawson, J. M., J. Tremble, C. Dayan, H. Beyan, R. D. Leslie, M. Peakman, and T. I. Tree. 2008. Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin. Exp. Immunol. 154: 353-359.
    • (2008) Clin. Exp. Immunol. , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3    Beyan, H.4    Leslie, R.D.5    Peakman, M.6    Tree, T.I.7
  • 65
    • 39749108699 scopus 로고    scopus 로고
    • Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism
    • Bynoe, M. S., and C. Viret. 2008. Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism. Trends Immunol. 29: 99-102.
    • (2008) Trends Immunol. , vol.29 , pp. 99-102
    • Bynoe, M.S.1    Viret, C.2
  • 68
    • 33845691031 scopus 로고    scopus 로고
    • + T cells in human type 1 diabetes: Report of the immunology of Diabetes Society T cell workshop
    • DOI 10.1196/annals.1375.002, Immunology of Diabetes IV: Progress in Our Understanding
    • Tree, T. I., B. O. Roep, and M. Peakman. 2006. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann. N. Y. Acad. Sci. 1079: 9-18. (Pubitemid 44968695)
    • (2006) Annals of the New York Academy of Sciences , vol.1079 , pp. 9-18
    • Tree, T.I.M.1    Roep, B.O.2    Peakman, M.3
  • 69
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • DOI 10.1172/JCI29251
    • Astier, A. L., G. Meiffren, S. Freeman, and D. A. Hafler. 2006. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J. Clin. Invest. 116: 3252-3257. (Pubitemid 44878639)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.12 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 71
    • 33846900430 scopus 로고    scopus 로고
    • high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X., C. Yarboro, G. Illei, and P. E. Lipsky. 2007. Deficient CD4+ CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 178: 2579-2588. (Pubitemid 46233461)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 72
    • 47249145164 scopus 로고    scopus 로고
    • -/low regulatory T cells in patients with active systemic lupus erythematosus
    • DOI 10.1002/art.23556
    • Venigalla, R. K., T. Tretter, S. Krienke, R. Max, V. Eckstein, N. Blank, C. Fiehn, A. D. Ho, and H. M. Lorenz. 2008. Reduced CD4+, CD25- T cell sensitivity to the suppressive function of CD4+, CD25high, CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum. 58: 2120-2130. (Pubitemid 351988104)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.7 , pp. 2120-2130
    • Venigalla, R.K.C.1    Tretter, T.2    Krienke, S.3    Max, R.4    Eckstein, V.5    Blank, N.6    Fiehn, C.7    Ho, A.D.8    Lorenz, H.-M.9
  • 73
    • 47249083906 scopus 로고    scopus 로고
    • high T cells in patients with new-onset systemic lupus erythematosus
    • DOI 10.1111/j.1365-2249.2008.03686.x
    • Zhang, B., X. Zhang, F. Tang, L. Zhu, and Y. Liu. 2008. Reduction of forkhead box P3 levels in CD4+CD25high T cells in patients with new-onset systemic lupus erythematosus. Clin. Exp. Immunol. 153: 182-187. (Pubitemid 351989160)
    • (2008) Clinical and Experimental Immunology , vol.153 , Issue.2 , pp. 182-187
    • Zhang, B.1    Zhang, X.2    Tang, F.3    Zhu, L.4    Liu, Y.5
  • 74
    • 43249122144 scopus 로고    scopus 로고
    • Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    • DOI 10.1177/0961203307088307
    • Vargas-Rojas, M. I., J. C. Crispín, Y. Richaud-Patin, and J. Alcocer-Varela. 2008. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 17: 289-294. (Pubitemid 351655795)
    • (2008) Lupus , vol.17 , Issue.4 , pp. 289-294
    • Vargas-Rojas, M.I.1    Crispin, J.C.2    Richaud-Patin, Y.3    Alcocer-Varela, J.4
  • 75
    • 44949174181 scopus 로고    scopus 로고
    • Natural regulatory T cells: Number and function are normal in the majority of patients with lupus nephritis
    • DOI 10.1111/j.1365-2249.2008.03665.x
    • Yates, J., A. Whittington, P. Mitchell, R. I. Lechler, L. Lightstone, and G. Lombardi. 2008. Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin. Exp. Immunol. 153: 44-55. (Pubitemid 351809334)
    • (2008) Clinical and Experimental Immunology , vol.153 , Issue.1 , pp. 44-55
    • Yates, J.1    Whittington, A.2    Mitchell, P.3    Lechler, R.I.4    Lightstone, L.5    Lombardi, G.6
  • 76
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • DOI 10.1084/jem.20040165
    • Ehrenstein, M. R., J. G. Evans, A. Singh, S. Moore, G. Warnes, D. A. Isenberg, and C. Mauri. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J. Exp. Med. 200: 277-285. (Pubitemid 39031247)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6    Mauri, C.7
  • 77
    • 58049196774 scopus 로고    scopus 로고
    • Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    • Flores-Borja, F., E. C. Jury, C. Mauri, and M. R. Ehrenstein. 2008. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 105: 19396-19401.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 19396-19401
    • Flores-Borja, F.1    Jury, E.C.2    Mauri, C.3    Ehrenstein, M.R.4
  • 78
    • 61449187505 scopus 로고    scopus 로고
    • Regulatory T cells overturned: The effectors fight back
    • Walker, L. S. 2009. Regulatory T cells overturned: the effectors fight back. Immunology 126: 466-474.
    • (2009) Immunology , vol.126 , pp. 466-474
    • Walker, L.S.1
  • 79
    • 33947496068 scopus 로고    scopus 로고
    • 'Vive la Résistance!' - The PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression
    • DOI 10.1016/j.it.2007.02.003, PII S1471490607000294
    • Wohlfert, E. A., and R. B. Clark. 2007. 'Vive la Résistance!': the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression. Trends Immunol. 28: 154-160. (Pubitemid 46467517)
    • (2007) Trends in Immunology , vol.28 , Issue.4 , pp. 154-160
    • Wohlfert, E.A.1    Clark, R.B.2
  • 81
    • 34447574943 scopus 로고    scopus 로고
    • + regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro
    • DOI 10.1093/intimm/dxm047
    • Yates, J., F. Rovis, P. Mitchell, B. Afzali, J. Y. Tsang, M. Garin, R. I. Lechler, G. Lombardi, and O. A. Garden. 2007. The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int. Immunol. 19: 785-799. (Pubitemid 47073268)
    • (2007) International Immunology , vol.19 , Issue.6 , pp. 785-799
    • Yates, J.1    Rovis, F.2    Mitchell, P.3    Afzali, B.4    Tsang, J.Y.-S.5    Garin, M.6    Lechler, R.I.7    Lombardi, G.8    Garden, O.A.9
  • 84
    • 33747034337 scopus 로고    scopus 로고
    • Regulation of regulatory T cells: Role of dendritic cells and Toll-like receptors
    • Kabelitz, D., D. Wesch, and H. H. Oberg. 2006. Regulation of regulatory T cells: role of dendritic cells and Toll-like receptors. Crit. Rev. Immunol. 26: 291-306.
    • (2006) Crit. Rev. Immunol. , vol.26 , pp. 291-306
    • Kabelitz, D.1    Wesch, D.2    Oberg, H.H.3
  • 85
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • DOI 10.1111/j.1600-065X.2008.00610.x
    • Katz, J. B., A. J.Muller, and G. C. Prendergast. 2008. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol. Rev. 222: 206-221. (Pubitemid 351430372)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 206-221
    • Katz, J.B.1    Muller, A.J.2    Prendergast, G.C.3
  • 86
    • 0025817428 scopus 로고
    • MHC class-II molecules and autoimmunity
    • Nepom, G. T., and H. Erlich. 1991. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9: 493-525.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 493-525
    • Nepom, G.T.1    Erlich, H.2
  • 87
    • 70449470314 scopus 로고    scopus 로고
    • The genetics of autoimmune diseases: A networked perspective
    • Baranzini, S. E. 2009. The genetics of autoimmune diseases: a networked perspective. Curr. Opin. Immunol. 21: 596-605.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 596-605
    • Baranzini, S.E.1
  • 88
    • 77950355043 scopus 로고    scopus 로고
    • Unraveling the genetics of autoimmunity
    • Zenewicz, L. A., C. Abraham, R. A. Flavell, and J. H. Cho. 2010. Unraveling the genetics of autoimmunity. Cell 140: 791-797.
    • (2010) Cell , vol.140 , pp. 791-797
    • Zenewicz, L.A.1    Abraham, C.2    Flavell, R.A.3    Cho, J.H.4
  • 89
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 93
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • International Multiple Sclerosis Genetics Consortium
    • Maier, L. M., C. E. Lowe, J. Cooper, K. Downes, D. E. Anderson, C. Severson, P. M. Clark, B. Healy, N. Walker, C. Aubin, et alInternational Multiple Sclerosis Genetics Consortium. 2009. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 5: e1000322.
    • (2009) PLoS Genet. , vol.5
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3    Downes, K.4    Anderson, D.E.5    Severson, C.6    Clark, P.M.7    Healy, B.8    Walker, N.9    Aubin, C.10
  • 95
  • 98
    • 33745174905 scopus 로고    scopus 로고
    • PTPN22: Setting thresholds for autoimmunity
    • DOI 10.1016/j.smim.2006.03.009, PII S1044532306000467
    • Gregersen, P. K., H. S. Lee, F. Batliwalla, and A. B. Begovich. 2006. PTPN22: setting thresholds for autoimmunity. Semin. Immunol. 18: 214-223. (Pubitemid 43903284)
    • (2006) Seminars in Immunology , vol.18 , Issue.4 , pp. 214-223
    • Gregersen, P.K.1    Lee, H.-S.2    Batliwalla, F.3    Begovich, A.B.4
  • 99
    • 34247213251 scopus 로고    scopus 로고
    • Is FCRL3 a New General Autoimmunity Gene?
    • DOI 10.1016/j.humimm.2007.01.013, PII S0198885907000250
    • Chistiakov, D. A., and A. P. Chistiakov. 2007. Is FCRL3 a new general autoimmunity gene? Hum. Immunol. 68: 375-383. (Pubitemid 46616981)
    • (2007) Human Immunology , vol.68 , Issue.5 , pp. 375-383
    • Chistiakov, D.A.1    Chistiakov, A.P.2
  • 100
    • 77951627133 scopus 로고    scopus 로고
    • Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1
    • Swainson, L. A., J. E. Mold, U. D. Bajpai, and J. M. McCune. 2010. Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1. J. Immunol. 184: 3639-3647.
    • (2010) J. Immunol. , vol.184 , pp. 3639-3647
    • Swainson, L.A.1    Mold, J.E.2    Bajpai, U.D.3    McCune, J.M.4
  • 101
    • 33750358659 scopus 로고    scopus 로고
    • high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids
    • DOI 10.1136/ard.2005.049924
    • Suárez, A., P. López, J. Gómez, and C. Gutiérrez. 2006. Enrichment of CD4+ CD25high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann. Rheum. Dis. 65: 1512-1517. (Pubitemid 44629132)
    • (2006) Annals of the Rheumatic Diseases , vol.65 , Issue.11 , pp. 1512-1517
    • Suarez, A.1    Lopez, P.2    Gomez, J.3    Gutierrez, C.4
  • 102
    • 77649235565 scopus 로고    scopus 로고
    • Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity
    • Zhang, L., X. Q. Yang, J. Cheng, R. S. Hui, and T. W. Gao. 2010. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin. Immunol. 135: 108-117.
    • (2010) Clin. Immunol. , vol.135 , pp. 108-117
    • Zhang, L.1    Yang, X.Q.2    Cheng, J.3    Hui, R.S.4    Gao, T.W.5
  • 103
    • 37149003363 scopus 로고    scopus 로고
    • high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
    • DOI 10.1111/j.1365-2567.2007.02690.x
    • Venken, K., N. Hellings, M. Thewissen, V. Somers, K. Hensen, J. L. Rummens, R. Medaer, R. Hupperts, and P. Stinissen. 2008. Compromised CD4(+) CD25 (high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 123: 79-89. (Pubitemid 350255996)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3    Somers, V.4    Hensen, K.5    Rummens, J.-L.6    Medaer, R.7    Hupperts, R.8    Stinissen, P.9


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