메뉴 건너뛰기




Volumn 86, Issue 2, 2015, Pages 208-215

Alemtuzumab treatment of multiple sclerosis: Long-term safety and efficacy

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTINUCLEAR ANTIBODY; AZATHIOPRINE; BETA INTERFERON; GLATIRAMER; IMMUNOGLOBULIN; MITOXANTRONE; RADIOACTIVE IODINE; RITUXIMAB; STEROID; THYROID PEROXIDASE ANTIBODY; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84921319094     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2014-307721     Document Type: Article
Times cited : (206)

References (22)
  • 1
    • 27944439639 scopus 로고    scopus 로고
    • Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis
    • Cox AL, Thompson SA, Jones JL, et al. Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis. Eur J Immunol 2005;35:3332-42.
    • (2005) Eur J Immunol , vol.35 , pp. 3332-3342
    • Cox, A.L.1    Thompson, S.A.2    Jones, J.L.3
  • 2
    • 84857055778 scopus 로고    scopus 로고
    • Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis
    • Hill-Cawthorne GA, Button T, Tuohy O, et al. Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 2012;83:298-304.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 298-304
    • Hill-Cawthorne, G.A.1    Button, T.2    Tuohy, O.3
  • 3
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs. interferon beta-1a in early multiple sclerosis
    • Coles AJ, Compston DA, Selmaj KW, et al. Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N Engl J Med 2008;359:1786-801.
    • (2008) N Engl J Med , vol.359 , pp. 1786-1801
    • Coles, A.J.1    Compston, D.A.2    Selmaj, K.W.3
  • 4
    • 84869492471 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled phase 3 trial
    • Cohen JA, Coles AJ, Arnold DL, et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet 2012;380:1819-28.
    • (2012) Lancet , vol.380 , pp. 1819-1828
    • Cohen, J.A.1    Coles, A.J.2    Arnold, D.L.3
  • 5
    • 84869507357 scopus 로고    scopus 로고
    • Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: A randomised controlled phase 3 trial
    • Coles AJ, Twyman CL, Arnold DL, et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012;380:1829-39.
    • (2012) Lancet , vol.380 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.L.2    Arnold, D.L.3
  • 6
    • 0033552391 scopus 로고    scopus 로고
    • Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
    • Coles AJ, Wing M, Smith S, et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 1999;354:1691-5.
    • (1999) Lancet , vol.354 , pp. 1691-1695
    • Coles, A.J.1    Wing, M.2    Smith, S.3
  • 7
    • 84860780657 scopus 로고    scopus 로고
    • Alemtuzumab more effective than interferon beta-1a at 5-year follow-up of CAMMS223 clinical trial
    • Coles AJ, Fox E, Vladic A, et al. Alemtuzumab more effective than interferon beta-1a at 5-year follow-up of CAMMS223 clinical trial. Neurology 2012;78:1069-78.
    • (2012) Neurology , vol.78 , pp. 1069-1078
    • Coles, A.J.1    Fox, E.2    Vladic, A.3
  • 8
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
    • Coles AJ, Cox A, Le Page E, et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol 2006;253:98-108.
    • (2006) J Neurol , vol.253 , pp. 98-108
    • Coles, A.J.1    Cox, A.2    Le Page, E.3
  • 9
    • 77956209762 scopus 로고    scopus 로고
    • A novel strategy to reduce the immunogenicity of biological therapies
    • Somerfield J, Hill-Cawthorne GA, Lin A, et al. A novel strategy to reduce the immunogenicity of biological therapies. J Immunol 2010;185:763-8.
    • (2010) J Immunol , vol.185 , pp. 763-768
    • Somerfield, J.1    Hill-Cawthorne, G.A.2    Lin, A.3
  • 10
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 11
    • 0029869119 scopus 로고    scopus 로고
    • Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
    • Moreau T, Coles A, Wing M, et al. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 1996;119 (Pt 1):225-37.
    • (1996) Brain , vol.119 , pp. 225-237
    • Moreau, T.1    Coles, A.2    Wing, M.3
  • 12
    • 79952740129 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: Post-hoc and subset analyses of clinical efficacy outcomes
    • Coles AJ, Fox E, Vladic A, et al. Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes. Lancet Neurol 2011;10:338-48.
    • (2011) Lancet Neurol , vol.10 , pp. 338-348
    • Coles, A.J.1    Fox, E.2    Vladic, A.3
  • 13
    • 0025055144 scopus 로고
    • Analysis of serial measurements in medical research
    • Matthews JN, Altman DG, Campbell MJ, et al. Analysis of serial measurements in medical research. BMJ 1990;300:230-5.
    • (1990) BMJ , vol.300 , pp. 230-235
    • Matthews, J.N.1    Altman, D.G.2    Campbell, M.J.3
  • 14
    • 0031747230 scopus 로고    scopus 로고
    • "Summary measure" statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis
    • Liu C, Li Wan Po A, Blumhardt LD. "Summary measure" statistic for assessing the outcome of treatment trials in relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 1998;64:726-9.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 726-729
    • Liu, C.1    Li Wan Po, A.2    Blumhardt, L.D.3
  • 15
    • 0032863847 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of interferon beta-1a in relapsing-remitting multiple sclerosis analysed by area under disability/time curves
    • Liu C, Blumhardt LD. Randomised, double blind, placebo controlled study of interferon beta-1a in relapsing-remitting multiple sclerosis analysed by area under disability/time curves. J Neurol Neurosurg Psychiatry 1999;67:451-6.
    • (1999) J Neurol Neurosurg Psychiatry , vol.67 , pp. 451-456
    • Liu, C.1    Blumhardt, L.D.2
  • 16
    • 0034101317 scopus 로고    scopus 로고
    • Disability outcome measures in therapeutic trials of relapsing-remitting multiple sclerosis: Effects of heterogeneity of disease course in placebo cohorts
    • Liu C, Blumhardt LD. Disability outcome measures in therapeutic trials of relapsing-remitting multiple sclerosis: effects of heterogeneity of disease course in placebo cohorts. J Neurol Neurosurg Psychiatry 2000;68:450-7.
    • (2000) J Neurol Neurosurg Psychiatry , vol.68 , pp. 450-457
    • Liu, C.1    Blumhardt, L.D.2
  • 17
  • 18
    • 0017360990 scopus 로고
    • The measurement of observer agreement for categorical data
    • Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33:159-74.
    • (1977) Biometrics , vol.33 , pp. 159-174
    • Landis, J.R.1    Koch, G.G.2
  • 19
    • 84890285333 scopus 로고    scopus 로고
    • Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation
    • Jones JL, Thompson SA, Loh P, et al. Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proc Natl Acad Sci USA 2013;110:20200-5.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 20200-20205
    • Jones, J.L.1    Thompson, S.A.2    Loh, P.3
  • 20
    • 52449117054 scopus 로고    scopus 로고
    • Disability as an outcome in MS clinical trials
    • Ebers GC, Heigenhauser L, Daumer M, et al. Disability as an outcome in MS clinical trials. Neurology 2008;71:624-31.
    • (2008) Neurology , vol.71 , pp. 624-631
    • Ebers, G.C.1    Heigenhauser, L.2    Daumer, M.3
  • 21
    • 68849084141 scopus 로고    scopus 로고
    • IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)
    • Jones JL, Phuah CL, Cox AL, et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest 2009;119:2052-61.
    • (2009) J Clin Invest , vol.119 , pp. 2052-2061
    • Jones, J.L.1    Phuah, C.L.2    Cox, A.L.3
  • 22
    • 84902179860 scopus 로고    scopus 로고
    • Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis
    • Azzopardi L, Thompson SA, Harding KE, et al. Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 2014;85:795-8.
    • (2014) J Neurol Neurosurg Psychiatry , vol.85 , pp. 795-798
    • Azzopardi, L.1    Thompson, S.A.2    Harding, K.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.