Synaptotagmins interact with APP and promote Aβ generation

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Gautam, Vivek ^a   D'Avanzo, Carla ^a   Berezovska, Oksana ^a   Tanzi, Rudolph E ^a   Kovacs, Dora M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; APP; APP interacting proteins; A ; BACE1; Proteomics; Synaptic vesicles; Synaptotagmin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; SYNAPTOTAGMIN; SYNAPTOTAGMIN 9; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; HYBRID PROTEIN; PEPTIDE FRAGMENT; SECRETASE; SMALL INTERFERING RNA; SYT1 PROTEIN, MOUSE; SYT1 PROTEIN, RAT; SYT2 PROTEIN, MOUSE; SYT9 PROTEIN, MOUSE; SYT9 PROTEIN, RAT;

AFFINITY CHROMATOGRAPHY; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHO CELL LINE; CONTROLLED STUDY; MASS SPECTROMETRY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CRICETULUS; DEFICIENCY; GENETICS; HAMSTER; METABOLISM; NERVE CELL; PC12 CELL LINE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; SECRETION (PROCESS); SPECIES DIFFERENCE;

RATTUS;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CHO CELLS; CRICETINAE; CRICETULUS; MICE; NEURONS; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPECIES SPECIFICITY; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; SYNAPTOTAGMINS;

EID: 84937412700     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0028-5     Document Type: Article

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