Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders

International Journal of Developmental Neuroscience

Volumn 46, Issue , 2015, Pages 27-32

  Han, Yu ^a   Xi, Qian qian ^a   Dai, Wei ^a   Yang, Shu han ^a   Gao, Lei ^a   Su, Yuan yuan ^a   Zhang, Xin ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Autism spectrum disorder; Chinese; Homocysteine; Oxidative stress; Transsulfuration metabolism

Indexed keywords

CYSTEINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HOMOCYSTEINE; ANTIOXIDANT;

ADULT; ANTIOXIDANT ASSAY; ARTICLE; AUTISM; BLOOD LEVEL; CHILD; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GLUTATHIONE DISULFIDE GLUTATHIONE RATIO; HUMAN; MALE; METABOLISM; MIDDLE AGED; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; SCHOOL CHILD; SYNDROME DELINEATION; TRANSSULFURATION METABOLISM; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CASE CONTROL STUDY; COMPLICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLIC DISEASES; NONPARAMETRIC TEST; PRESCHOOL CHILD; SEVERITY OF ILLNESS INDEX; STATISTICS;

ANTIOXIDANTS; ASIAN CONTINENTAL ANCESTRY GROUP; AUTISM SPECTRUM DISORDER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; FEMALE; GLUTATHIONE; HOMOCYSTEINE; HUMANS; MALE; METABOLIC DISEASES; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; STATISTICS, NONPARAMETRIC;

EID: 84937139819     PISSN: 07365748     EISSN: 1873474X     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2015.06.006     Document Type: Article

References (62)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed.
2. Barnea-Goraly N., Frazier T.W., Piacenza L., Minshew N.J., Keshavan M.S., Reiss A.L., et al. A preliminary longitudinal volumetric MRI study of amygdala and hippocampal volumes in autism. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2014, 48:124-128.
3. Boyle C.A., Boulet S., Schieve L.A., Cohen R.A., Blumberg S.J., Yeargin-Allsopp M., et al. Trends in the prevalence of developmental disabilities in US children, 1997-2008. Pediatrics 2008, 127:1034-1042.
4. Brosnan J.T., Jacobs R.L., Stead L.M., Brosnan M.E. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim. Pol. 2004, 51:405-413.
5. Budge M.M., de Jager C., Hogervorst E., Smith Optima A.D. Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J. Am. Geriatr. Soc. 2002, 50:2014-2018.
6. Castro C., Millian N.S., Garrow T.A. Liver betaine-hornocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch. Biochem. Biophys. 2008, 472:26-33.
7. Chiocchetti A.G., Haslinger D., Boesch M., Karl T., Wiemann S., Freitag C.M., et al. Protein signatures of oxidative stress response in a patient specific cell line model for autism. Mol. Autism 2014, 5:15.
8. Chlebowski C., Green J.A., Barton M.L., Fein D. Using the childhood autism rating scale to diagnose autism spectrum disorders. J. Autism Dev. Disord. 2010, 40:787-799.
9. Christie L.A., Riedel G., Platt B. Bi-directional alterations of LTP after acute homocysteine exposure. Behav. Brain Res. 2009, 205:559-563.
10. Dhonukshe-Rutten R.A.M., de Vries J.H.M., de Bree A., van der Put N., van Staveren W.A., de Groot L.C.P.G.M. Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. Eur. J. Clin. Nutr. 2009, 63:18-30.
11. Dittmann S., Seemuller F., Grunze H.C., Schwarz M.J., Zach J., Fast K., et al. The impact of homocysteine levels on cognition in euthymic bipolar patients: a cross-sectional study. J. Clin. Psychiatry 2008, 69:899-906.
12. dos Santos P.A.C., Longo D., Brandalize A.P.C., Schuler-Faccini L. MTHFR C677T is not a risk factor for autism spectrum disorders in South Brazil. Psychiatr. Genet. 2010, 20:187-189.
13. Dringen R., Hirrlinger J. Glutathione pathways in the brain. Biol. Chem. 2003, 384:505-516.
14. Feng L., Ng T.-P., Chuah L., Niti M., Kua E.-H. Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore longitudinal ageing study. Am. J. Clin. Nutr. 2006, 84:1506-1512.
15. Finkelstein J.D. The metabolism of homocysteine: pathways and regulation. Eur. J. Pediatr. 1998, 157:S40-S44.
16. Fombonne E. Epidemiology of autistic disorder and other pervasive developmental disorders. J. Clin. Psychiatry 2005, 66:3-8.
17. Frustaci A., Neri M., Cesario A., Adams J.B., Domenici E., Dalla Bernardina B., et al. Oxidative stress-related biomarkers in autism: systematic review and meta-analyses. Free Radic. Biol. Med . 2012, 52:2128-2141.
18. Geier D.A., Geier M.R. A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders. Horm. Res. 2006, 66:182-188.
19. Gentile I., Zappulo E., Militerni R., Pascotto A., Borgia G., Bravaccio C. Etiopathogenesis of autism spectrum disorders: fitting the pieces of the puzzle together. Med. Hypotheses 2013, 81:26-35.
20. Ghanizadeh A. Increased glutamate and homocysteine and decreased glutamine levels in autism: a review and strategies for future studies of amino acids in autism. Dis. Markers 2013, 35:281-286.
21. Hardan A.Y., Fung L.K., Libove R.A., Obukhanych T.V., Nair S., Herzenberg L.A., et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol. Psychiatry 2012, 71:956-961.
22. Hallmayer J., Cleveland S., Torres A., Phillips J., Cohen B., Torigoe T., et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch. Gen. Psychiatry 2011, 68:1095-1102.
23. Hooshmand B., Solomon A., Kareholt I., Rusanen M., Hanninen T., Leiviska J., et al. Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study. J. Intern. Med. 2012, 271:204-212.
24. Jakubowski H., Glowacki R. Chemical biology of homocysteine thiolactone and related metabolites. Adv. Clin. Chem. 2011, 55:81-103.
25. James S.J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D.W., et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr. 2004, 80:1611-1617\.
26. James S.J., Melnyk S., Jernigan S., Cleves M.A., Halsted C.H., Wong D.H., et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006, 141B:947-956.
27. James S.J., Melnyk S., Jernigan S., Hubanks A., Rose S., Gaylor D.W. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J. Autism Dev. Disord. 2008, 38:1966-1975.
28. Kale A., Naphade N., Sapkale S., Kamaraju M., Pillai A., Joshi S., et al. Reduced folic acid, vitamin B-12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: Implications for altered one-carbon metabolism. Psychiatry Res. 2010, 175:47-53.
29. Kern J.K., Geier D.A., Adams J.B., Garver C.R., Audhya T., Geier M.R. A clinical trial of glutathione supplementation in autism spectrum disorders. Med. Sci. Monit. 2011, 17:677-682.
30. Kral T.V.E., Eriksen W.T., Souders M.C., Pinto-Martin J.A. Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review. J. Pediatr. Nurs. Nurs. Care Children Families 2013, 28:548-556.
31. Krebs M.O., Bellon A., Mainguy G., Jay T.M., Frieling H. One-carbon metabolism and schizophrenia: current challenges and future directions. Trends Mol. Med. 2009, 15:562-570.
32. Kruman, Culmsee C., Chan S.L., Kruman Y., Guo Z.H., Penix L., et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 2000, 20:6920-6926.
33. Loureiro S.O., Romao L., Alves T., Fonseca A., Heimfarth L., Moura Neto V., et al. Homocysteine induces cytoskeletal remodeling and production of reactive oxygen species in cultured cortical astrocytes. Brain Res. 2010, 1355:151-164.
34. Margis R., Dunand C., Teixeira F.K., Margis-Pinheiro M. Glutathione peroxidase family - an evolutionary overview. FEBS J. 2008, 275:3959-3970.
35. Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003, 26:137-146.
36. Mosharov E., Cranford M.R., Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry 2000, 39:13005-13011.
37. Mostafa G.A., El-Hadidi E.S., Hewedi D.H., Abdou M.M. Oxidative stress in Egyptian children with autism: relation to autoimmunity. J. Neuroimmunol. 2010, 219:114-118.
38. Olteanu H., Banerjee R. Redundancy in the pathway for redox regulation of mammalian methionine synthase - reductive activation by the dual flavoprotein, novel reductase 1. J. Biol. Chem. 2003, 278:38310-38314.
39. Parellada M., Moreno C., Mac-Dowell K., Leza J.C., Giraldez M., Bailon C., et al. Plasma antioxidant capacity is reduced in Asperger syndrome. J. Psychiatr Res . 2012, 46:394-401.
40. Pasca S.P., Nemes B., Vlase L., Gagyi C.E., Dronca E., Miu A.C., et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci. 2006, 78:2244-2248.
41. Pereira A.C., Schettert I.T., Morandini A.A.F., Guerra-Shinohara E.M., Krieger J.E. Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population. Clin. Chim. Acta 2004, 340:99-105.
42. Perla-Kajan J., Twardowski T., Jakubowski H. Mechanisms of homocysteine toxicity in humans. Amino Acids 2007, 32:561-572.
43. Prudova A., Bauman Z., Braun A., Vitvitsky V., Lu S.C., Banerjee R. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:6489-6494.
44. Rabaneda L.G., Carrasco M., Lopez-Toledano M.A., Murillo-Carretero M., Ruiz F.A., Estrada C. Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J. 2008, 22:3823-3835.
45. Reed M.C., Thomas R.L., Pavisic J., James S.J., Ulrich C.M., Nijhout H.F. A mathematical model of glutathione metabolism. Theor. Biol. Med. Model. 2008, 5. 16.
46. Rose S., Melnyk S., Pavliv O., Bai S., Nick T.G., Frye R.E., James S.J. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl. Psychiatry 2012, 2:e134.
47. Rossignol D.A., Genuis S.J., Frye R.E. Environmental toxicants and autism spectrum disorders: a systematic review. Transl. Psychiatry 2014, 4.
48. Schmidt R.J., Hansen R.L., Hartiala J., Allayee H., Schmidt L.C., Tancredi D.J., et al. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology 2011, 22:476-485.
49. Schopler E., Reichler R.J., DeVellis R.F., Daly K. Toward objective classification of childhood autism: childhood autism rating scale (CARS). J. Autism Dev. Disord. 1980, 10:91-103.
50. Stanger O., Fowler B., Piertzik K., Huemer M., Haschke-Becher E., Semmler A., et al. Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Rev. Neurother. 2009, 9:1393-1412.
51. Sugranyes G., Kyriakopoulos M., Corrigall R., Taylor E., Frangou S. Autism spectrum disorders and schizophrenia: meta-analysis of the neural correlates of social cognition. PLoS One 2011, 6.
52. Sun X., Allison C., Matthews F.E., Sharp S.J., Auyeung B., Baron-Cohen S., et al. Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis. Mol Autism 2013, 4:7.
53. Tachimori H., Osada H., Kurita H. Childhood autism rating scale - Tokyo version for screening pervasive developmental disorders. Psychiatry Clin. Neurosci. 2003, 57:113-118.
54. Tu W.J., Yin C.H., Guo Y.Q., Li S.O., Chen H., Zhang Y., Feng Y.L., et al. Serum homocysteine concentrations in Chinese children with autism. Clin. Chem. Lab. Med. 2013, 51:e19-e22.
55. Tyagi N., Sedoris K.C., Steed M., Ovechkin A.V., Moshal K.S., Tyagi S.C. Mechanisms of homocysteine-induced oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H2649-H2656.
56. Vogel T., Dali-Youcef N., Kaltenbach G., Andres E. Homocysteine, vitamin B-12, folate and cognitive functions: a systematic and critical review of the literature. Int. J. Clin. Pract. 2009, 63:1061-1067.
57. Volkmar F.R., Cicchetti D.V., Dykens E., Sparrow S.S., Leckman J.F., Cohen D.J. An evaluation of the autism behavior checklist. J. Autism Dev. Disord. 1988, 18:81-97.
58. Wijsman C.A., van Heemst D., Rozing M.P., Slagboom P.E., Beekman M., de Craen A.J.M., et al. Homocysteine and familial longevity: the leiden longevity study. PLoS One 2011, 6.
59. Xia R.R. Effectiveness of nutritional supplements for reducing symptoms in autism-spectrum disorder: a case report. J. Altern. Complement. Med. 2011, 17:271-274.
60. Xia W., Zhou Y., Sun C., Wang J., Wu L. A preliminary study on nutritional status and intake in Chinese children with autism. Eur. J. Pediatr. 2010, 169:1201-1206.
61. Zimmer M.H., Hart L.C., Manning-Courtney P., Murray D.S., Bing N.M., Summer S. Food variety as a predictor of nutritional status among children with autism. J. Autism Dev. Disord. 2012, 42:549-556.
62. Zou C.G., Banerjee R. Homocysteine and redox signaling. Antioxid. Redox Signaling 2005, 7:547-559.