A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders

Hormone Research

Volumn 66, Issue 4, 2006, Pages 182-188

  Geier, David A ^a,b   Geier, Mark R ^b  

^a MedCon Inc   (United States)

^b Genetic Centers of America   (United States)

Author keywords

Pervasive developmental delay; Precocious puberty; Sex steroid hormones; Sexual development

Indexed keywords

ANDROGEN; CYSTEINE; FOLLITROPIN; GLUTATHIONE; METHIONINE; PRASTERONE; TESTOSTERONE;

ARTICLE; AUTISM; CHILD; CHRONIC DISEASE; CLINICAL ARTICLE; FEMALE; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPERANDROGENISM; MALE; METABOLITE; OUTPATIENT CARE; PREPUBERTY; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR;

ANDROGENS; AUTISTIC DISORDER; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; CYSTATHIONINE; CYSTEINE; DEHYDROEPIANDROSTERONE; FEMALE; FOLLICLE STIMULATING HORMONE; GLUTATHIONE; HOMOCYSTEINE; HUMANS; MALE; METHIONINE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SULFURTRANSFERASES; TESTOSTERONE;

EID: 33748774908     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094467     Document Type: Article

References (18)

1. Bertrand J, Mars A, Boyle C, Bove F, Yeargin-Allsopp M, Decoufle P: Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation. Pediatrics 2001;108:1155-1161.
2. Eigsti IM, Shapiro T: A systems neuroscience approach to autism: biological, cognitive, and clinical perspectives. Ment Retard Dev Disabil Res Rev 2003;9:205-215.
3. White JF: Intestinal pathology in autism. Exp Biol Med (Maywood) 2003;228:639-649.
4. Sweeten TL, Bowyer SL, Posey DJ, Halberstadt GM, McDougle CJ: Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics 2003;112:E420-E424.
5. Bolte S, Poustka F: The relation between general cognitive level and adaptive behavior domains in individuals with autism with and without comorbid mental retardation. Child Psychiatry Hum Dev 2002;33:165-172.
6. Geier MR, Geier DA: The potential importance of steroids in the treatment of autistic spectrum disorders and other disorders involving mercury toxicity. Med Hypotheses 2005;64:946-954.
7. Werner E, Dawson G: Validation of the phenomenon of autistic regression using home videotapes. Arch Gen Psychiatry 2005;62:889-895.
8. James SJ, Culter P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA: Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004;80:1611-1617.
9. Ryan RA, Carrol J: Studies on a 3-beta-hydroxysteroid sulphotransferase from rat liver. Biochim Biophys Acta 1976;429:391-401.
10. Strous RD, Golubchik P, Maayan R, Mozes T, Tuati-Werner D, Weizman A, Spivak B: Lowered DHEA-S plasma levels in adult individuals with autistic disorder. Eur Neuropsychopharmacol 2005;15:305-309.
11. Tordjman S, Ferrari P, Sulmont V, Duyme M, Roubertoux P: Androgenic activity in autism. Am J Psychiatry 1997;154:1626-1627.
12. Baron-Cohen S, Knickmeyer RC, Belmonte MK: Sex differences in the brain: implications for explaining autism. Science 2005;310:819-823.
13. Siddiqi SU, Van Dyke DC, Donohoue P, McBrien DM: Premature sexual development in individuals with neurodevelopmental disabilities. Dev Med Child Neurol 1999;41:392-395.
14. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD: Effects of sex steroids on plasma total homocysteine levels: a study in transsexual males and females. J Clin Endocrinol Metab 1998;83:550-553.
15. Giltay EJ, Verhoef P, Gooren LJ, Geleijnse JM, Schouten EG, Stehouwer CD: Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals. Atherosclerosis 2003;168:139-146.
16. Vrbikova J, Tallova J, Bicikova M, Dvorakova K, Hill M, Starka L: Plasma thiols and androgen levels in polycystic ovary syndrome. Clin Chem Lab Med 2003;41:216-221.
17. Boris M, Goldblatt A, Galanko J, James SJ: Association of 5,10-Methylenetetrathydrofolate reductase (MTHFR) gene polymorphisms with autistic spectrum disorders. J Am Phys Surg 2004;9:106-108.
18. Pasca SP, Nemes B, Vlase L, Gagvi CE, Dronca E, Miu AC, Dronca M: High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci 2006;78:2244-2248.