High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism

Life Sciences

Volumn 78, Issue 19, 2006, Pages 2244-2248

  Paşca, Sergiu P ^a,b   Nemeş, Bogdan ^a   Vlase, Laurian ^a   Gagyi, Cristina E ^a   Dronca, Eleonora ^a   Miu, Andrei C ^c   Dronca, Maria ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b Center for Cognitive and Neural Studies Coneural   (Romania)

^c BABE BOLYAI UNIVERSITY   (Romania)

Author keywords

Autism; B12; Glutathione peroxidase; Homocysteine; Paraoxonase 1

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; ARYLESTERASE; BIOLOGICAL MARKER; CYANOCOBALAMIN; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME ANALYSIS; ERYTHROCYTE; FEMALE; HUMAN; MALE; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ARYLDIALKYLPHOSPHATASE; AUTISTIC DISORDER; CARBOXYLIC ESTER HYDROLASES; CHILD; ERYTHROCYTES; FEMALE; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HUMANS; MALE; VITAMIN B 12;

EID: 33645238117     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.09.040     Document Type: Article

References (40)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders: DSM-IV fourth ed. 1994 American Psychiatric Association Washington, DC
2. M. Aviram, E. Hardak, J. Vaya, S. Mahmood, S. Milo, A. Hoffman, S. Billicke, D. Draganov, and M. Rosenblat Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities Circulation 101 21 2000 2510 2517
3. M. Boris, A. Goldblatt, J. Galanko, and J.S. James Association of MTHFR gene variants with autism Journal of American Physicians and Surgeons 9 2004 106 108
4. V.H. Brophy, G.P. Jarvik, R.J. Richter, L.S. Rozek, G.D. Schellenberg, and C.E. Furlong Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype Pharmacogenetics 10 5 2000 453 460
5. S. Chakrabarti, and E. Fombonne Pervasive developmental disorders in preschool children: confirmation of high prevalence The American Journal of Psychiatry 162 6 2005 1133 1141
6. J.F. Chasse Inverse correlation between phenylacetate hydrolase activity of the serum PON1 protein and homocysteinemia in humans Thrombosis and Haemostasis 93 1 2005 182 183
7. V. Chauhan, A. Chauhan, I.L. Cohen, W.T. Brown, and A. Sheikh Alteration in amino-glycerophospholipids levels in the plasma of children with autism: a potential biochemical diagnostic marker Life Sciences 74 13 2004 1635 1643
8. A. Chauhan, V. Chauhan, W.T. Brown, and I. Cohen Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin - the antioxidant proteins Life Sciences 75 21 2004 2539 2549
9. M. D'Amelio, I. Ricci, R. Sacco, X. Liu, L. D'Agruma, L.A. Muscarella, V. Guarnieri, R. Militerni, C. Bravaccio, M. Elia, C. Schneider, R. Melmed, S. Trillo, T. Pascucci, S. Puglisi-Allegra, K.L. Reichelt, F. Macciardi, J.J. Holden, and A.M. Persico Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions Molecular Psychiatry 2005 (advance online publication 19 July 2005)
10. D. Drabkin, and H. Austin Spectrophotometric studies preparations from washed blood cells Journal of Biological Chemistry 112 1 1935 51 55
11. P.N. Durrington, B. Mackness, and M.I. Mackness Paraoxonase and atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology 21 4 2001 473 480
12. H.W. Eckerson, J. Romson, C. Wyte, and B.N. La Du The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts American Journal of Human Genetics 35 2 1983 214 227
13. I.M. Eigsti, and T. Shapiro A systems neuroscience approach to autism: biological, cognitive, and clinical perspectives Mental Retardation and Developmental Disabilities Research Reviews 9 3 2003 205 215
14. G. Ferretti, T. Bacchetti, E. Marotti, and G. Curatola Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity Metabolism: Clinical and Experimental 52 2 2003 146 151
15. E. Fombonne Epidemiological surveys of autism and other pervasive developmental disorders: an update Journal of Autism and Developmental Disorders 33 4 2003 365 382
16. P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, R.G. Matthews, G.J. Boers, M. den Heijer, L.A. Kluijtmans, and L.P. van den Heuvel A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nature Genetics 10 1 1995 111 113
17. B. Golse, P. Debray-Ritzen, P. Durosay, K. Puget, and A.M. Michelson Alterations in two enzymes: superoxide dismutase and glutathione peroxidase in developmental infantile psychosis (infantile autism) Revue Neurologique (Paris) 134 11 1978 699 707
18. D.E. Handy, Y. Zhang, and J. Loscalzo Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation The Journal of Biological Chemistry 280 16 2005 15518 15525
19. H. Jakubowski Homocysteine-thiolactone and S-nitroso-homocysteine mediate incorporation of homocysteine into protein in humans Clinical Chemistry and Laboratory Medicine 41 11 2003 1462 1466
20. S.J. James, P. Cutler, S. Melnyk, S. Jernigan, L. Janak, D.W. Gaylor, and J.A. Neubrander Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism The American Journal of Clinical Nutrition 80 6 2004 1611 1617
21. 12 in autism and neuropsychiatric disturbances of childhood Journal of The American Academy of Child Psychiatry 20 1 1981 104 111
22. M.P. Mattson, and T.B. Shea Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders Trends in Neurosciences 26 3 2003 137 146
23. N. Micali, S. Chakrabarti, and E. Fombonne The broad autism phenotype: findings from an epidemiological survey Autism 8 1 2004 21 37
24. K. Miyazaki, N. Narita, R. Sakuta, T. Miyahara, H. Naruse, N. Okado, and M. Narita Serum neurotrophin concentrations in autism and mental retardation: a pilot study Brain and Development 26 5 2004 292 295
25. 12 and folate depletion in cognition: a review Neurology India 52 3 2004 310 318
26. P. Moretti, T. Sahoo, K. Hyland, T. Bottiglieri, S. Peters, D. del Gaudio, B. Roa, S. Curry, H. Zhu, R.H. Finnell, J.L. Neul, V.T. Ramaekers, N. Blau, C.A. Bacino, G. Miller, and F. Scaglia Cerebral folate deficiency with developmental delay, autism, and response to folinic acid Neurology 64 6 2005 1088 1090
27. R. Muhle, S.V. Trentacoste, and I. Rapin The genetics of autism Pediatrics 113 5 2004 472 486
28. K.B. Nelson Toward a biology of autism: possible role of certain neuropeptides and neurotrophins Clinical Neuroscience Research 1 2001 300 306
29. D.E. Paglia, and W.N. Valentine Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase The Journal of Laboratory and Clinical Medicine 70 1 1967 158 169
30. I. Rapin Autism The New England Journal of Medicine 337 2 1997 97 104
31. K. Robert, J.F. Chasse, D. Santiard-Baron, C. Vayssettes, A. Chabli, J. Aupetit, N. Maeda, P. Kamoun, J. London, and N. Janel Altered gene expression in liver from a murine model of hyperhomocysteinemia The Journal of Biological Chemistry 278 34 2003 31504 31511
32. P. Sachdev Homocysteine and neuropsychiatric disorders Revista Brasileira de Psiquiatria 26 1 2004 50 56
33. R. Vanhala, U. Turpeinen, and R. Riikonen Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism Developmental Medicine and Child Neurology 43 9 2001 614 616
34. A.J. Wakefield, S.H. Murch, A. Anthony, J. Linnell, D.M. Casson, M. Malik, M. Berelowitz, A.P. Dhillon, M.A. Thomson, P. Harvey, A. Valentine, S.E. Davies, and J.A. Walker-Smith Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children Lancet 351 9123 1998 637 641
35. M. Waly, H. Olteanu, R. Banerjee, S.W. Choi, J.B. Mason, B.S. Parker, S. Sukumar, S. Shim, A. Sharma, J.M. Benzecry, V.A. Power-Charnitsky, and R.C. Deth Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal Molecular Psychiatry 9 4 2004 358 370
36. P.M. Whitaker-Azmitia Serotonin and brain development: role in human developmental diseases Brain Research Bulletin 56 5 2001 479 485
37. J.F. White Intestinal pathophysiology in autism Experimental Biology and Medicine (Maywood) 228 6 2003 639 649
38. M. Yeargin-Allsopp, C. Rice, T. Karapurkar, N. Doernberg, C. Boyle, and C. Murphy Prevalence of autism in a US metropolitan area JAMA 289 1 2003 49 55
39. O. Yorbik, A. Sayal, C. Akay, D.I. Akbiyik, and T. Sohmen Investigation of antioxidant enzymes in children with autistic disorder Prostaglandins, Leukotrienes, and Essential Fatty Acids 67 5 2002 341 343
40. C.G. Zou, and R. Banerjee Homocysteine and redox signaling Antioxidants and Redox Signaling 7 5-6 2005 547 559