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Volumn 35, Issue 5, 2013, Pages 281-286

Increased glutamate and homocysteine and decreased glutamine levels in autism: A review and strategies for future studies of amino acids in autism

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CITRULLINE; ESSENTIAL AMINO ACID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HOMOCYSTEINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NEUROTRANSMITTER; PHENYLALANINE; PROLINE; SERINE; TAURINE; THREONINE; TRYPTOPHAN; TYROSINE; VALINE;

EID: 84884845794     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.1155/2013/536521     Document Type: Review
Times cited : (65)

References (43)
  • 1
    • 84887228464 scopus 로고    scopus 로고
    • Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: A brief review
    • 10.1016/j.pedn.2013.01.008
    • Kral T. V., Eriksen W. T., Souders M. C., Pinto-Martin J. A., Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review. Journal of Pediatric Nursing 2013 10.1016/j.pedn.2013.01.008
    • (2013) Journal of Pediatric Nursing
    • Kral, T.V.1    Eriksen, W.T.2    Souders, M.C.3    Pinto-Martin, J.A.4
  • 2
    • 0035495690 scopus 로고    scopus 로고
    • An Assessment of Food Acceptance in Children with Autism or Pervasive Developmental Disorder-Not Otherwise Specified
    • DOI 10.1023/A:1012221026124
    • Ahearn W. H., Castine T., Nault K., Green G., An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified. Journal of Autism and Developmental Disorders 2001 31 5 505 511 2-s2.0-0035495690 10.1023/A:1012221026124 (Pubitemid 37486686)
    • (2001) Journal of Autism and Developmental Disorders , vol.31 , Issue.5 , pp. 505-511
    • Ahearn, W.H.1    Castine, T.2    Nault, K.3    Green, G.4
  • 3
    • 58549096699 scopus 로고    scopus 로고
    • Does nutritional intake differ between children with autism spectrum disorders and children with typical development?
    • 2-s2.0-58549096699 10.1007/s10803-008-0606-2
    • Herndon A. C., DiGuiseppi C., Johnson S. L., Leiferman J., Reynolds A., Does nutritional intake differ between children with autism spectrum disorders and children with typical development? Journal of Autism and Developmental Disorders 2009 39 2 212 222 2-s2.0-58549096699 10.1007/s10803-008-0606-2
    • (2009) Journal of Autism and Developmental Disorders , vol.39 , Issue.2 , pp. 212-222
    • Herndon, A.C.1    Diguiseppi, C.2    Johnson, S.L.3    Leiferman, J.4    Reynolds, A.5
  • 5
    • 33644782771 scopus 로고    scopus 로고
    • 6 in children with autism not taking supplements compared to controls not taking supplements
    • DOI 10.1089/acm.2006.12.59
    • Adams J. B., George F., Audhya T., Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. Journal of Alternative and Complementary Medicine 2006 12 1 59 63 2-s2.0-33644782771 10.1089/acm.2006.12.59 (Pubitemid 43346324)
    • (2006) Journal of Alternative and Complementary Medicine , vol.12 , Issue.1 , pp. 59-63
    • Adams, J.B.1    George, F.2    Audhya, T.3
  • 6
    • 33846627653 scopus 로고    scopus 로고
    • Relationship of Dietary Intake to Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders
    • DOI 10.1016/j.biopsych.2006.07.013, PII S0006322306009371, Advances in Understending and Treating Autism Spectrum Disorders
    • Levy S. E., Souders M. C., Ittenbach R. F., Giarelli E., Mulberg A. E., Pinto-Martin J. A., Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry 2007 61 4 492 497 2-s2.0-33846627653 10.1016/j.biopsych.2006.07.013 (Pubitemid 46185339)
    • (2007) Biological Psychiatry , vol.61 , Issue.4 , pp. 492-497
    • Levy, S.E.1    Souders, M.C.2    Ittenbach, R.F.3    Giarelli, E.4    Mulberg, A.E.5    Pinto-Martin, J.A.6
  • 7
  • 8
    • 0141427890 scopus 로고    scopus 로고
    • Plasma amino acids profiles in children with autism: Potential risk of nutritional deficiencies
    • DOI 10.1023/A:1025071014191
    • Arnold G. L., Hyman S. L., Mooney R. A., Kirby R. S., Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. Journal of Autism and Developmental Disorders 2003 33 4 449 454 2-s2.0-0141427890 10.1023/A:1025071014191 (Pubitemid 37127941)
    • (2003) Journal of Autism and Developmental Disorders , vol.33 , Issue.4 , pp. 449-454
    • Arnold, G.L.1    Hyman, S.L.2    Mooney, R.A.3    Kirby, R.S.4
  • 10
    • 0037296984 scopus 로고    scopus 로고
    • Plasma amino acid levels in children with autism and their families
    • DOI 10.1023/A:1022238706604
    • Aldred S., Moore K. M., Fitzgerald M., Waring R. H., Plasma amino acid levels in children with autism and their families. Journal of Autism and Developmental Disorders 2003 33 1 93 97 2-s2.0-0037296984 10.1023/A: 1022238706604 (Pubitemid 36323144)
    • (2003) Journal of Autism and Developmental Disorders , vol.33 , Issue.1 , pp. 93-97
    • Aldred, S.1    Moore, K.M.2    Fitzgerald, M.3    Waring, R.H.4
  • 11
    • 80054060035 scopus 로고    scopus 로고
    • Could fever and neuroinflammation play a role in the neurobiology of autism? A subject worthy of more research
    • 2-s2.0-80054060035 10.3109/02656736.2011.604665
    • Ghanizadeh A., Could fever and neuroinflammation play a role in the neurobiology of autism? A subject worthy of more research. International Journal of Hyperthermia 2011 27 7 737 738 2-s2.0-80054060035 10.3109/02656736.2011. 604665
    • (2011) International Journal of Hyperthermia , vol.27 , Issue.7 , pp. 737-738
    • Ghanizadeh, A.1
  • 12
    • 79954433555 scopus 로고    scopus 로고
    • Targeting of glycine site on NMDA receptor as a possible new strategy for autism treatment
    • 2-s2.0-79954433555 10.1007/s11064-010-0381-2
    • Ghanizadeh A., Targeting of glycine site on NMDA receptor as a possible new strategy for autism treatment. Neurochemical Research 2011 36 5 922 923 2-s2.0-79954433555 10.1007/s11064-010-0381-2
    • (2011) Neurochemical Research , vol.36 , Issue.5 , pp. 922-923
    • Ghanizadeh, A.1
  • 13
    • 78650719460 scopus 로고    scopus 로고
    • Methionine sulfoximine may improve inflammation in autism, a novel hypothesized treatment for autism
    • 2-s2.0-78650719460 10.1016/j.arcmed.2010.10.012
    • Ghanizadeh A., Methionine sulfoximine may improve inflammation in autism, a novel hypothesized treatment for autism. Archives of Medical Research 2010 41 8 651 652 2-s2.0-78650719460 10.1016/j.arcmed.2010.10.012
    • (2010) Archives of Medical Research , vol.41 , Issue.8 , pp. 651-652
    • Ghanizadeh, A.1
  • 14
    • 77649185238 scopus 로고    scopus 로고
    • A possible research and clinical implication of association of homocysteine and glutamate levels in brain for management of aggression
    • 2-s2.0-77649185238 10.1016/j.ijdevneu.2010.01.003
    • Ghanizadeh A., Namazi M. R., A possible research and clinical implication of association of homocysteine and glutamate levels in brain for management of aggression. International Journal of Developmental Neuroscience 2010 28 2, article 125 2-s2.0-77649185238 10.1016/j.ijdevneu.2010.01.003
    • (2010) International Journal of Developmental Neuroscience , vol.28 , Issue.2 ARTICLE 125
    • Ghanizadeh, A.1    Namazi, M.R.2
  • 16
    • 84868605782 scopus 로고    scopus 로고
    • Application of LC-MS/MS analysis of plasma amino acids profiles in children with autism
    • 10.3164/jcbn.12-45
    • Tu W.-J., Chen H., He J., Application of LC-MS/MS analysis of plasma amino acids profiles in children with autism. Journal of Clinical Biochemistry and Nutrition 2012 51 3 248 249 10.3164/jcbn.12-45
    • (2012) Journal of Clinical Biochemistry and Nutrition , vol.51 , Issue.3 , pp. 248-249
    • Tu, W.-J.1    Chen, H.2    He, J.3
  • 18
    • 0023872943 scopus 로고
    • Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers
    • DOI 10.1016/0006-3223(88)90052-2
    • Alfredsson G., Wiesel F.-A., Tylec A., Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers. Biological Psychiatry 1988 23 7 689 697 2-s2.0-0023872943 (Pubitemid 18086648)
    • (1988) Biological Psychiatry , vol.23 , Issue.7 , pp. 689-697
    • Alfredsson, G.1    Wiesel, F.-A.2    Tylec, A.3
  • 21
    • 0018118909 scopus 로고
    • Amino compounds and organic acids in CSF, plasma, and urine of autistic children
    • Perry T. L., Hansen S., Christie R. G., Amino compounds and organic acids in CSF, plasma, and urine of autistic children. Biological Psychiatry 1978 13 5 575 586 2-s2.0-0018118909 (Pubitemid 9041465)
    • (1978) Biological Psychiatry , vol.13 , Issue.5 , pp. 575-586
    • Perry, T.L.1    Hansen, S.2    Christie, R.G.3
  • 24
    • 33645238117 scopus 로고    scopus 로고
    • High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
    • 2-s2.0-33645238117 10.1016/j.lfs.2005.09.040
    • Paşca S. P., Nemeş B., Vlase L., Gagyi C. E., Dronca E., Miu A. C., Dronca M., High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sciences 2006 78 19 2244 2248 2-s2.0-33645238117 10.1016/j.lfs.2005.09.040
    • (2006) Life Sciences , vol.78 , Issue.19 , pp. 2244-2248
    • Paşca, S.P.1    Nemeş, B.2    Vlase, L.3    Gagyi, C.E.4    Dronca, E.5    Miu, A.C.6    Dronca, M.7
  • 25
    • 15244348759 scopus 로고    scopus 로고
    • Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    • James S. J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D. W., Neubrander J. A., Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American Journal of Clinical Nutrition 2004 80 6 1611 1617 2-s2.0-15244348759 (Pubitemid 41103861)
    • (2004) American Journal of Clinical Nutrition , vol.80 , Issue.6 , pp. 1611-1617
    • James, S.J.1    Cutler, P.2    Melnyk, S.3    Jernigan, S.4    Janak, L.5    Gaylor, D.W.6    Neubrander, J.A.7
  • 26
    • 79953177534 scopus 로고    scopus 로고
    • Homocysteine level in urine of autistic and healthy children
    • 2-s2.0-79953177534
    • Kałuzna-Czaplińska J., Michalska M., Rynkowski J., Homocysteine level in urine of autistic and healthy children. Acta Biochimica Polonica 2011 58 1 31 34 2-s2.0-79953177534
    • (2011) Acta Biochimica Polonica , vol.58 , Issue.1 , pp. 31-34
    • Kałuzna-Czaplińska, J.1    Michalska, M.2    Rynkowski, J.3
  • 27
    • 0027322233 scopus 로고
    • Serotonin and amino acid content in platelets of autistic children
    • Rolf L. H., Haarmann F. Y., Grotemeyer K.-H., Kehrer H., Serotonin and amino acid content in platelets of autistic children. Acta Psychiatrica Scandinavica 1993 87 5 312 316 2-s2.0-0027322233 (Pubitemid 23134638)
    • (1993) Acta Psychiatrica Scandinavica , vol.87 , Issue.5 , pp. 312-316
    • Rolf, L.H.1    Haarmann, F.Y.2    Grotemeyer, K.-H.3    Kehrer, H.4
  • 31
    • 34848842158 scopus 로고    scopus 로고
    • The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
    • DOI 10.1016/j.neuint.2007.03.012, PII S0197018607000770
    • Sheldon A. L., Robinson M. B., The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochemistry International 2007 51 6-7 333 355 2-s2.0-34848842158 10.1016/j.neuint.2007.03.012 (Pubitemid 47503456)
    • (2007) Neurochemistry International , vol.51 , Issue.6-7 , pp. 333-355
    • Sheldon, A.L.1    Robinson, M.B.2
  • 32
    • 39749165772 scopus 로고    scopus 로고
    • The hyperglutamatergic hypothesis of autism
    • DOI 10.1016/j.pnpbp.2007.11.004, PII S0278584607003946
    • Fatemi S. H., The hyperglutamatergic hypothesis of autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2008 32 3, article 911 2-s2.0-39749165772 10.1016/j.pnpbp.2007.11.004 (Pubitemid 351312357)
    • (2008) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.32 , Issue.3 , pp. 911
    • Fatemi, S.H.1
  • 33
    • 62349130905 scopus 로고    scopus 로고
    • Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders
    • 2-s2.0-62349130905 10.2174/092986709787002745
    • Blaylock R. L., Strunecka A., Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Current Medicinal Chemistry 2009 16 2 157 170 2-s2.0-62349130905 10.2174/092986709787002745
    • (2009) Current Medicinal Chemistry , vol.16 , Issue.2 , pp. 157-170
    • Blaylock, R.L.1    Strunecka, A.2
  • 34
    • 0037108019 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices
    • 2-s2.0-0037108019 10.1016/S0006-3223(02)01430-0
    • Fatemi S. H., Halt A. R., Stary J. M., Kanodia R., Schulz S. C., Realmuto G. R., Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Biological Psychiatry 2002 52 8 805 810 2-s2.0-0037108019 10.1016/S0006-3223(02)01430-0
    • (2002) Biological Psychiatry , vol.52 , Issue.8 , pp. 805-810
    • Fatemi, S.H.1    Halt, A.R.2    Stary, J.M.3    Kanodia, R.4    Schulz, S.C.5    Realmuto, G.R.6
  • 38
    • 84861633498 scopus 로고    scopus 로고
    • Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items
    • Ghanizadeh A., Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. Journal of Research in Medical Sciences 2012 17 4 368 372
    • (2012) Journal of Research in Medical Sciences , vol.17 , Issue.4 , pp. 368-372
    • Ghanizadeh, A.1
  • 39
    • 0142073438 scopus 로고    scopus 로고
    • Diagnosis and Epidemiology of Autism Spectrum Disorders
    • Tidmarsh L., Volkmar F. R., Diagnosis and epidemiology of autism spectrum disorders. Canadian Journal of Psychiatry 2003 48 8 517 525 2-s2.0-0142073438 (Pubitemid 37280041)
    • (2003) Canadian Journal of Psychiatry , vol.48 , Issue.8 , pp. 517-525
    • Tidmarsh, L.1    Volkmar, F.R.2
  • 40
    • 84872413630 scopus 로고    scopus 로고
    • Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders
    • 10.1007/s10802-012-9668-x
    • Mazurek M. O., Vasa R. A., Kalb L. G., Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders. Journal of Abnormal Child Psychology 2013 41 1 165 176 10.1007/s10802-012-9668-x
    • (2013) Journal of Abnormal Child Psychology , vol.41 , Issue.1 , pp. 165-176
    • Mazurek, M.O.1    Vasa, R.A.2    Kalb, L.G.3
  • 41
    • 84866426000 scopus 로고    scopus 로고
    • Does the human gut microbiota contribute to the etiology of autism spectrum disorders?
    • Louis P., Does the human gut microbiota contribute to the etiology of autism spectrum disorders? Digestive Diseases and Sciences 2012 57 8 1987 1989
    • (2012) Digestive Diseases and Sciences , vol.57 , Issue.8 , pp. 1987-1989
    • Louis, P.1
  • 42
    • 77949362543 scopus 로고    scopus 로고
    • 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Psycho-neuroimmunology and the intestinal microbiota: Clinical observations and basic mechanisms
    • 2-s2.0-77949362543 10.1111/j.1365-2249.2010.04124.x
    • Bienenstock J., Collins S., 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: psycho-neuroimmunology and the intestinal microbiota: clinical observations and basic mechanisms. Clinical and Experimental Immunology 2010 160 1 85 91 2-s2.0-77949362543 10.1111/j.1365-2249. 2010.04124.x
    • (2010) Clinical and Experimental Immunology , vol.160 , Issue.1 , pp. 85-91
    • Bienenstock, J.1    Collins, S.2
  • 43
    • 84859266528 scopus 로고    scopus 로고
    • Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism
    • 2-s2.0-84859266528 10.1016/j.febslet.2012.01.049
    • Clayton T. A., Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism. FEBS Letters 2012 586 7 956 961 2-s2.0-84859266528 10.1016/j.febslet.2012.01.049
    • (2012) FEBS Letters , vol.586 , Issue.7 , pp. 956-961
    • Clayton, T.A.1


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