Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

Genes and Development

Volumn 29, Issue 13, 2015, Pages 1416-1431

  Ni, Lisheng ^a   Zheng, Yonggang ^b   Hara, Mayuko ^a   Pan, Duojia ^b   Luo, Xuelian ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoinhibition; Lats1; Mob1; Mst2; NMR; Phosphorylation; X ray crystallography

Indexed keywords

ADAPTOR PROTEIN; LATS KINASE; MOB1 PROTEIN; MST KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; HIPPO PROTEIN, HUMAN; LATS1 PROTEIN, HUMAN; MOB1A PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STK3 PROTEIN, HUMAN;

ALLOSTERISM; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; BIOCHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DROSOPHILA; HIPPO TUMOR SUPPRESSIVE PATHWAY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; DROSOPHILA MELANOGASTER; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; SEQUENCE ALIGNMENT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELLS, CULTURED; CRYSTALLIZATION; DROSOPHILA MELANOGASTER; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 84936998216     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.264929.115     Document Type: Article

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