Structural and Functional Analysis of Saccharomyces cerevisiae Mob1

Journal of Molecular Biology

Volumn 362, Issue 3, 2006, Pages 430-440

  Mrkobrada, Serge ^a,b   Boucher, Lorrie ^a,b   Ceccarelli, Derek F J ^a   Tyers, Mike ^a,b   Sicheri, Frank ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

cell cycle; mitotic exit network; Mob1; Saccharomyces cerevisiae; X ray crystallography

Indexed keywords

PROTEIN; PROTEIN MOB1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; X RAY CRYSTALLOGRAPHY; XENOPUS;

SACCHAROMYCES CEREVISIAE;

EID: 33748125359     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.07.007     Document Type: Article

References (28)

1. Luca F.C., and Winey M. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol. Biol. Cell 9 (1998) 29-46
2. Komarnitsky S.I., Chiang Y.C., Luca F.C., Chen J., Toyn J.H., Winey M., et al. DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein. Mol. Cell Biol. 18 (1998) 2100-2107
3. Lee S.E., Frenz L.M., Wells N.J., Johnson A.L., and Johnston L.H. Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5. Curr. Biol. 11 (2001) 784-788
4. Mah A.S., Jang J., and Deshaies R.J. Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc. Natl Acad. Sci. USA 98 (2001) 7325-7330
5. Justice R.W., Zilian O., Woods D.F., Noll M., and Bryant P.J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9 (1995) 534-546
6. Xu T., Wang W., Zhang S., Stewart R.A., and Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121 (1995) 1053-1063
7. Zallen J.A., Peckol E.L., Tobin D.M., and Bargmann C.I. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol. Biol. Cell 11 (2000) 3177-3190
8. Jeffrey P.D., Russo A.A., Polyak K., Gibbs E., Hurwitz J., Massague J., and Pavletich N.P. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376 (1995) 313-320
9. Morgan D.O. The dynamics of cyclin dependent kinase structure. Curr. Opin. Cell Biol. 8 (1996) 767-772
10. Nasmyth K. At the heart of the budding yeast cell cycle. Trends Genet. 12 (1996) 405-412
11. Morgan D.O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13 (1997) 261-291
12. Bardin A.J., and Amon A. Men and sin: what's the difference?. Nature Rev. Mol. Cell Biol. 2 (2001) 815-826
13. Nelson B., Kurischko C., Horecka J., Mody M., Nair P., Pratt L., et al. RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol. Biol. Cell 14 (2003) 3782-3803
14. Weiss E.L., Kurischko C., Zhang C., Shokat K., Drubin D.G., and Luca F.C. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J. Cell Biol. 158 (2002) 885-900
15. Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., and Sakaki Y. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl Acad. Sci. USA 98 (2001) 4569-4574
16. Devroe E., Erdjument-Bromage H., Tempst P., and Silver P.A. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J. Biol. Chem. 279 (2004) 24444-24451
17. Lai Z.C., Wei X., Shimizu T., Ramos E., Rohrbaugh M., Nikolaidis N., et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120 (2005) 675-685
18. He Y., Emoto K., Fang X., Ren N., Tian X., Jan Y.N., and Adler P.N. Drosophila Mob family proteins interact with the related Tricornered (Trc) and Warts (Wts) Kinases. Mol. Biol. Cell. 16 (2005) 4139-4152
19. St John M.A., Tao W., Fei X., Fukumoto R., Carcangiu M.L., Brownstein D.G., et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nature Genet. 21 (1999) 182-186
20. McPherson J.P., Tamblyn L., Elia A., Migon E., Shehabeldin A., Matysiak-Zablocki E., et al. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23 (2004) 3677-3688
21. Ponchon L., Dumas C., Kajava A.V., Fesquet D., and Padilla A. NMR solution structure of Mob1, a mitotic exit network protein and its interaction with an NDR kinase peptide. J. Mol. Biol. 337 (2004) 167-182
22. Stavridi E.S., Harris K.G., Huyen Y., Bothos J., Verwoerd P.M., Stayrook S.E., et al. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure (Camb) 11 (2003) 1163-1170
23. Wybenga-Groot L.E., Baskin B., Ong S.H., Tong J., Pawson T., and Sicheri F. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell 106 (2001) 745-757
24. Otwinowski Z., and Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276 (1997) 307-326
25. de La Fortelle E., and Bricogne G. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods. Methods Enzymol. 276 (1997) 472-494
26. De Bondt H.L., Rosenblatt J., Jancarik J., Jones H.D., Morgan D.O., and Kim S.H. Crystal structure of cyclin-dependent kinase 2. Nature 363 (1993) 595-602
27. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallog. sect. D 54 (1998) 905-921
28. Brachmann C.B., Davies A., Cost G.J., Caputo E., Li J., Hieter P., and Boeke J.D. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14 (1998) 115-132