Increased GADD34 in oligodendrocytes in Alzheimer's disease

Neuroscience Letters

Volumn 602, Issue , 2015, Pages 50-55

  Honjo, Yasuyuki ^a   Ayaki, Takashi ^a   Tomiyama, Takami ^b   Horibe, Tomohisa ^a   Ito, Hidefumi ^c   Mori, Hiroshi ^b   Takahashi, Ryosuke ^a   Kawakami, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; ER stress; GADD34; Oligodendrocytes

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R15A PROTEIN, HUMAN;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION; ANIMAL; BRAIN; CASE CONTROL STUDY; GENETICS; METABOLISM; MIDDLE AGED; TRANSGENIC MOUSE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MICE, TRANSGENIC; MIDDLE AGED; NEURONS; OLIGODENDROGLIA; PROTEIN PHOSPHATASE 1;

EID: 84936888584     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.06.052     Document Type: Article

References (27)

1. Lindholm D., Wootz H., Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differ. 2006, 13:385-392.
2. Doyle K.M., Kennedy D., Gorman A.M., Gupta S., Healy S.J., Samali A. Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J. Cell Mol. Med. 2011, 15:2025-2039.
3. Goedert M., Sisodia S.S., Price D.L. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Curr. Opin. Neurobiol. 1991, 1:441-447.
4. Xu J., Chen S., Ahmed S.H., Chen H., Ku G., Goldberg M.P., Hsu C.Y. Amyloid-beta peptides are cytotoxic to oligodendrocytes. J. Neurosci. 2001, 21:RC118.
5. Desai M.K., Sudol K.L., Janelsins M.C., Mastrangelo M.A., Frazer M.E., Bowers W.J. An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia 2011, 59:627-640.
6. Mitew S., Kirkcaldie M.T., Halliday G.M., Shepherd C.E., Vickers J.C., Dickson T.C. Focal demyelination in Alzheimer's disease and transgenic mouse models. Acta Neuropathol. 2010, 119:567-577.
7. Desai M.K., Sudol K.L., Janelsins M.C., Mastrangelo M.A., Frazer M.E., Bowers W.J. Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia 2009, 57:54-65.
8. Desai M.K., Mastrangelo M.A., Ryan D.A., Sudol K.L., Narrow W.C., Bowers W.J. Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target. Am. J. Pathol. 2010, 177:1422-1435.
9. Connor J.H., Weiser D.C., Li S., Hallenbeck J.M., Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol. Cell Biol. 2001, 21:6841-6850.
10. White F., McCaig D., Brown S.M., Graham D.I., Harland J., Macrae I.M. Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. Neuropathol. Appl. Neurobiol. 2004, 30:683-691.
11. McCaig D., Imai H., Gallagher L., Graham D.I., Harland J., Moira Brown S., Mhairi Macrae I. Evolution of GADD34 expression after focal cerebral ischaemia. Brain Res. 2005, 1034:51-61.
12. Morton E., Macrae I.M., McCabe C., Brown S.M., White F. Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. Int. J. Cardiol. 2006, 107:126-129.
13. Jaronen M., Vehviläinen P., Malm T., Keksa-Goldsteine V., Pollari E., Valonen P., Koistinaho J., Goldsteins G. Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production. Hum. Mol. Genet. 2013, 22:646-655.
14. Wang L., Popko B., Roos R.P. An enhanced integrated stress response ameliorates mutant SOD1-induced ALS. Hum. Mol. Genet. 2014, 23:2629-2638.
15. Honjo Y., Ito H., Horibe T., Takahashi R., Kawakami K. Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res. 2010, 1349:90-96.
16. Honjo Y., Horibe T., Torisawa A., Ito H., Nakanishi A., Mori H., Komiya T., Takahashi R., Kawakami K. Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease. J. Alzheimers Dis. 2014, 38:601-609.
17. Tomiyama T., Matsuyama S., Iso H., Umeda T., Takuma H., Ohnishi K., Ishibashi K., Teraoka R., Sakama N., Yamashita T., Nishitsuji K., Ito K., Shimada H., Lambert M.P., Klein W.L., Mori H. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci. 2010, 30:4845-4856.
18. Umeda T., Tomiyama T., Sakama N., Tanaka S., Lambert M.P., Klein W.L., Mori H. Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. J. Neurosci. Res. 2011, 89:1031-1042.
19. Nishitsuji K., Tomiyama T., Ishibashi K., Ito K., Teraoka R., Lambert M.P., Klein W.L., Mori H. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. Am. J. Pathol. 2009, 174:957-969.
20. Klein W.L., Krafft G.A., Finch C.E. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?. Trends Neurosci. 2001, 24:219-224.
21. Shankar G.M., Li S., Mehta T.H., Garcia-Munoz A., Shepardson N.E., Smith I., Brett F.M., Farrell M.A., Rowan M.J., Lemere C.A., Regan C.M., Walsh D.M., Sabatini B.L., Selkoe D.J. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 2008, 14:837-842.
22. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416:535-539.
23. Lue L.F., Kuo Y.M., Roher A.E., Brachova L., Shen Y., Sue L., Beach T., Kurth J.H., Rydel R.E., Rogers J. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 1999, 155:853-862.
24. Dodart J.C., Bales K.R., Gannon K.S., Greene S.J., DeMattos R.B., Mathis C., DeLong C.A., Wu S., Wu X., Holtzman D.M., Paul S.M. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 2002, 5:452-457.
25. Patterson A.D., Hollander M.C., Miller G.F., Fornace A.J. Gadd34 requirement for normal hemoglobin synthesis. Mol. Cell Biol. 2006, 26:1644-1653.
26. Zhan Q., Lord K.A., Alamo I., Hollander M.C., Carrier F., Ron D., Kohn K.W., Hoffman B., Liebermann D.A., Fornace A.J. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell Biol. 1994, 14:2361-2371.
27. Kojima E., Takeuchi A., Haneda M., Yagi A., Hasegawa T., Yamaki K., Takeda K., Akira S., Shimokata K., Isobe K. The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 2003, 17:1573-1575.