Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 38, Issue 3, 2014, Pages 601-609

  Honjo, Yasuyuki ^a   Horibe, Tomohisa ^a   Torisawa, Aya ^a   Ito, Hidefumi ^b   Nakanishi, Aki ^c   Mori, Hiroshi ^d   Komiya, Tohru ^e   Takahashi, Ryosuke ^a   Kawakami, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^c Osaka City Kosaiin Hospital   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Alzheimer's disease; endoplasmic reticulum stress; misfolding; neurofibrillary tangle; nitric oxide; protein disulfide isomerase; protein disulfide isomerase P5; S nitrosylation; tau

Indexed keywords

NITRIC OXIDE; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE P5; SMALL INTERFERING RNA; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; NITROSYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION;

ALZHEIMER'S DISEASE; ENDOPLASMIC RETICULUM STRESS; MISFOLDING; NEUROFIBRILLARY TANGLE; NITRIC OXIDE; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE P5; S-NITROSYLATION; TAU;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; NEUROBLASTOMA; NEUROFIBRILLARY TANGLES; NEUROGLIA; NEURONS; PROTEIN DISULFIDE-ISOMERASES; TAU PROTEINS; TIME FACTORS;

EID: 84889670353     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130632     Document Type: Article

References (20)

1. Morishima-Kawashima M, Ihara Y (2002) Alzheimer's disease: Beta-Amyloid protein and tau. J Neurosci Res 70, 392-401.
2. Cras P, KawaiM, Lowery D, Gonzalez-DeWhitt P, Greenberg B, PerryG(1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci U S A 88, 7552-7556.
3. Nakamura T, Lipton SA (2009) Cell death: Protein misfolding and neurodegenerative diseases. Apoptosis 14, 455-468.
4. Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, Vitek MP (2008) The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15, 571-587.
5. Kimura T, Horibe T, Sakamoto C, Shitara Y, Fujiwara F, Komiya T, Yamamoto A, Hayano T, Takahashi N, KikuchiM (2008) Evidence for mitochondrial localization of P5, a member of the protein disulphide isomerase family. J Biochem 144, 187-196.
6. Noiva R, Lennarz WJ (1992) Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum. J Biol Chem 267, 3553-3556.
7. Kimura T, Nishida A, Ohara N, Yamagishi D, Horibe T, Kikuchi M (2004) Functional analysis of the CXXC motif using phage antibodies that cross-react with protein disulphide-isomerase family proteins. Biochem J 382, 169-176.
8. Shitara Y, Tonohora Y, Goto T, YamadaY, Miki T, Makino H, Miwa M, Komiya T (2012) Mitochondrial P5, a member of protein disulphide isomerase family, suppresses oxidative stress-induced cell death. J Biochem 152, 73-85.
9. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA (2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441, 513-517.
10. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K (2010) Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res 1349, 90-96.
11. Hoozemans JJ, Veerhuis R, Van Haastert ES, Rozemuller JM, Baas F, Eikelenboom P, Scheper W (2005) The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol 110, 165-172.
12. Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K (2012) Derlin-1-immunopositive inclusions in patients with Alzheimer's disease. NeuroReport 23, 611-615.
13. Kohno M, HoribeT, Haramoto M,YanoY, Ohara K, Nakajima O, Matsuzaki K, Kawakami K (2011) A novel hybrid peptide targeting EGFR-expressing cancers. Eur J Cancer 47, 773-783.
14. Horibe T, Kohno M, Haramoto M, Ohara K, Kawakami K (2011) Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. J Transl Med 14, 8.
15. Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G (2000) Protein disulfide isomerase in Alzheimer disease. Antioxid Redox Signal 2, 485-489.
16. Nuss JE, Choksi KB, DeFord JH, Papaconstantinou J (2008) Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers. Biochem Biophys Res Commun 365, 355-361.
17. Yang Y, Turner RS, Gaut JR (1998) The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. J Biol Chem 273, 25552-25555.
18. Hoozemans JJ, Stieler J, van Haastert ES, Veerhuis R, Rozemuller AJ, Baas F, Eikelenboom P, Arendt T, Scheper W (2006) The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis. Exp Gerontol 41, 380-386.
19. Jessop CE, Watkins RH, Simmons JJ, Tasab M, Bulleid NJ (2009) Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. J Cell Sci 122, 4287-4295.
20. Walker AK, Farg MA, Bye CR, McLean CA, Horne MK, Atkin JD (2010) Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis. Brain 133, 105-116.