Cilostazol attenuates murine hepatic ischemia and reperfusion injury via heme oxygenase-dependent activation of mitochondrial biogenesis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 309, Issue 1, 2015, Pages

  Joe, Yeonsoo ^a   Zheng, Min ^a,b   Kim, Hyo Jeong ^a   Uddin, Md Jamal ^a   Kim, Seul Ki ^a   Chen, Yingqing ^a   Park, Jeongmin ^a   Cho, Gyeong Jae ^c   Ryter, Stefan W ^d   Chung, Hun Taeg ^a  

^a University of Ulsan   (South Korea)

^b YANBIAN UNIVERSITY   (China)

^c Gyeongsang National University School of Medicine   (South Korea)

^d WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Cilostazol; HO 1; Ischemia reperfusion; Mitochondrial biogenesis; Nrf 2

Indexed keywords

ALANINE AMINOTRANSFERASE; CILOSTAZOL; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 3; CYCLOOXYGENASE IV; CYTOPROTECTIVE AGENT; HEME OXYGENASE 1; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MYELOPEROXIDASE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROSTAGLANDIN SYNTHASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; HMOX1 PROTEIN, HUMAN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; PHOSPHODIESTERASE III INHIBITOR; PPARGC1A PROTEIN, MOUSE; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; TETRAZOLE DERIVATIVE; TFAM PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CONTENT; GENE SILENCING; IN VITRO STUDY; LIVER CELL; LIVER ISCHEMIA; LIVER PROTECTION; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL PROTECTION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; HUMAN; KNOCKOUT MOUSE; LIVER; LIVER MITOCHONDRION; METABOLISM; MITOCHONDRIAL DYNAMICS; PATHOLOGY; VASCULARIZATION;

ANIMALS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HEP G2 CELLS; HIGH MOBILITY GROUP PROTEINS; HUMANS; LIVER; MEMBRANE PROTEINS; MICE, INBRED BALB C; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL TURNOVER; NF-E2-RELATED FACTOR 2; PHOSPHODIESTERASE 3 INHIBITORS; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TETRAZOLES; TRANSCRIPTION FACTORS;

EID: 84936873149     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00307.2014     Document Type: Article

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