Associations of cord blood metabolites with early childhood obesity risk

International Journal of Obesity

Volumn 39, Issue 7, 2015, Pages 1041-1048

  Isganaitis, E ^a   Rifas Shiman, S L ^b   Oken, E ^b   Dreyfuss, J M ^a,c   Gall, W ^d   Gillman, M W ^b   Patti, M E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD PILGRIM HEALTH CARE INSTITUTE   (United States)

^c Boston University   (United States)

^d METABOLON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; DIMETHYLGLYCINE; GLUTAMIC ACID; GLUTAMINE; LEUCINE; N ACETYLMETHIONINE; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN BETAINE; TRYPTOPHYL LEUCINE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CASE CONTROL STUDY; CHILD; CHILDHOOD OBESITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATERNAL AGE; METABOLITE; METABOLOME; PRIORITY JOURNAL; RISK; UMBILICAL CORD BLOOD; WEIGHT GAIN; BIRTH WEIGHT; BLOOD; CHEMISTRY; FETUS BLOOD; INFANT; MALE; METABOLIC SYNDROME X; MOTHER; NEWBORN; PEDIATRIC OBESITY; PREGNANCY; PRENATAL EXPOSURE; RISK FACTOR;

ADULT; BIOMARKERS; BIRTH WEIGHT; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; FETAL BLOOD; HUMANS; INFANT; INFANT, NEWBORN; MALE; METABOLIC SYNDROME X; METABOLOME; MOTHERS; PEDIATRIC OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS; WEIGHT GAIN;

EID: 84936847304     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2015.39     Document Type: Article

References (34)

1. Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353: 1802-1809.
2. Leunissen RW, Kerkhof GF, Stijnen T, Hokken-Koelega A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA 2009; 301: 2234-2242.
3. Taveras EM, Rifas-Shiman SL, Belfort MB, Kleinman KP, Oken E, Gillman MW. Weight status in the first 6 months of life and obesity at 3 years of age. Pediatrics 2009; 123: 1177-1183.
4. Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, Decoste J, Vokes M et al. Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes 2009; 58: 1192-1200.
5. Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R et al. Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Diabetologia 2006; 49: 1974-1984.
6. Michaliszyn SF, Sjaarda LA, Mihalik SJ, Lee S, Bacha F, Chace DH et al. Metabolomic profiling of amino acids and beta-cell function relative to insulin sensitivity in youth. J Clin Endocrinol Metab 2012; 97: E2119-E2124.
7. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011; 17: 448-453.
8. Ivorra C, Garcia-Vicent C, Chaves FJ, Monleon D, Morales JM, Lurbe E. Metabolomic profiling in blood from umbilical cords of low birth weight newborns. J Transl Med 2012; 10: 142.
9. La TD, Seppanen-Laakso T, Larsson HE, Hyotylainen T, Ivarsson SA, Lernmark A et al. Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes. Diabetes 2013; 62: 3951-3956.
10. Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De MD et al. Cohort profile: Project Viva. Int J Epidemiol 2014; 44: 37-48.
11. Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J et al. An atlas of genetic influences on human blood metabolites. Nat Genet 2014; 46: 543-550.
12. Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ et al. alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 2010; 5: e10883.
13. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100: 9440-9445.
14. Xia J, Psychogios N, Young N, Wishart DS. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res 2009; 37: W652-W660.
15. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D et al. Metabolite profiling identifies pathways associated with metabolic risk in humans. Cirulation 2012; 125: 2222-2231.
16. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M et al. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest 2008; 118: 3503-3512.
17. Mihalik SJ, Michaliszyn SF, de las HJ, Bacha F, Lee S, Chace DH et al. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care 2012; 35: 605-611.
18. McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE et al. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr Obes 2012; 8: 52-61.
19. Tea I, Le GG, Kuster A, Guignard N, Alexandre-Gouabau MC, Darmaun D et al. 1H-NMRbased metabolic profiling of maternal and umbilical cord blood indicates altered materno-foetal nutrient exchange in preterm infants. PLoS One 2012; 7: e29947.
20. Walsh BH, Broadhurst DI, Mandal R, Wishart DS, Boylan GB, Kenny LC et al. The metabolomic profile of umbilical cord blood in neonatal hypoxic ischaemic encephalopathy. PLoS One 2012; 7: e50520.
21. Servillo L, Giovane A, Balestrieri ML, Ferrari G, Cautela D, Castaldo D. Occurrence of pipecolic acid and pipecolic acid betaine (homostachydrine) in Citrus genus plants. J Agric Food Chem 2012; 60: 315-321.
22. Guertin KA, Moore SC, Sampson JN, Huang WY, Xiao Q, Stolzenberg-Solomon RZ et al. Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. Am J Clin Nutr 2014; 100: 208-217.
23. Deguchi T, Kouno Y, Terasaki T, Takadate A, Otagiri M. Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm Res 2005; 22: 619-627.
24. Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW et al. The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta cell dysfunction. Cell Metab 2014; 19: 653-666.
25. Murrin C, Shrivastava A, Kelleher CC. Maternal macronutrient intake during pregnancy and 5 years postpartum and associations with child weight status aged five. Eur J Clin Nutr 2013; 67: 670-679.
26. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006; 51: 239-249.
27. Ozawa M, Honda K, Nakai I, Kishida A, Ohsaki A. Hypaphorine an indole alkaloid from Erythrina velutina, induced sleep on normal mice. Bioorg Med Chem Lett 2008; 18: 3992-3994.
28. Keller BO, Wu BT, Li SS, Monga V, Innis SM. Hypaphorine is present in human milk in association with consumption of legumes. J Agric Food Chem 2013; 61: 7654-7660.
29. Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 2014; 21: 166-172.
30. Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y et al. Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy. Proc Natl Acad Sci USA 2013; 110: 19420-19425.
31. Zhu X, Song J, Mar MH, Edwards LJ, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. Biochem J 2003; 370: 987-993.
32. Alexandre-Gouabau MC, Courant F, Moyon T, Kuster A, Le GG, Tea I et al. Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism, and oxidative stress in very-low birth weight infants. J Proteome Res 2013; 12: 2764-2778.
33. Askanazi J, Carpentier YA, Michelsen CB, Elwyn DH, Furst P, Kantrowitz LR et al. Muscle and plasma amino acids following injury. Influence of intercurrent infection. Ann Surg 1980; 192: 78-85.
34. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di PN et al. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA 2013; 310: 821-828.