Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages

  Michaliszyn, Sara F ^a   Sjaarda, Lindsey A ^a   Mihalik, Stephanie J ^b   Lee, SoJung ^a   Bacha, Fida ^c   Chace, Donald H ^d   De Jesus, Victor R ^e   Vockley, Jerry ^a,b   Arslanian, Silva A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d PEDIATRIX MEDICAL GROUP   (United States)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; AMINO ACID; ARGININE; C3 ACYLCARNITINE; C4 ACYLCARNITINE; C5 ACYLCARNITINE; GLYCINE; HISTIDINE; INSULIN; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG; VALINE;

ADOLESCENT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY WEIGHT; CLAMP; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; DISPOSITION INDEX; DYSGLYCEMIA; FEMALE; GLUCOSE TOLERANCE; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; RATING SCALE; TANDEM MASS SPECTROMETRY;

ADOLESCENT; AMINO ACIDS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; OBESITY; PREDICTIVE VALUE OF TESTS;

EID: 84868628375     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2170     Document Type: Article

References (24)

1. Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL, Ilkayeva OR, Wenner BR, Bain JR, Lee JJ, Lim SC, Khoo CM, Shah SH, Newgard CB 2010 Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia 53:757-767
2. Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy Jr WS, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP 2009 A branched chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9:311-326
3. Kim JY, Park JY, Kim OY, Ham BM, Kim HJ, Kwon DY, Jang Y, Lee JH 2010 Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 9:4368-4375
4. Bolea S, Pertusa JA, Martín F, Sanchez-Andrés JV, Soria B 1997 Regulation of pancreatic β-cell electrical activity and insulin release by physiological amino acid concentrations. Pflugers Arch 433:699-704 (Pubitemid 27140492)
5. Newsholme P, Brennan L, Bender K 2006 Amino acid metabolic, β-cell function, and diabetes. Diabetes 55(Suppl. 2):S39-S47 (Pubitemid 44927031)
6. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE 2011 Metabolite profiles and the risk of developing diabetes. Nat Med 17:448-453
7. Adams SH 2011 Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr 2:445-456
8. Mihalik SJ, Michaliszyn SF, de las Heras J, Bacha F, Lee S, Chace DH, DeJesus VR, Vockley J, Arslanian SA 2012 Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care 35:605-611
9. Gungor N, Bacha F, Saad R, Janosky J, Arslanian S 2005 Youth type 2 diabetes: insulin resistance, beta-cell failure, or both? Diabetes Care 28:638-644
10. Bacha F, Lee S, Gungor N, Arslanian SA 2010 From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 33:2225-2231
11. Lyssenko V, Almgren P, Anevski D, Perfekt R, Lahti K, Nissén M, Isomaa B, Forsen B, Homström N, Saloranta C, Taskinen MR, Groop L, Tuomi T 2005 Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54:166-174 (Pubitemid 40105109)
12. Burns SF, Bacha F, Lee SJ, Tfayli H, Gungor N, Arslanian SA 2011 Declining β-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth. Diabetes Care 34:2033-2040
13. Sjaarda LG, Bacha F, Lee S, Tfayli H, Andreatta E, Arslanian S 2012 Oral disposition index in obese youth from normal to prediabetes to diabetes: relationship to clamp disposition index. J Pediatr 161:51-57
14. Tfayli H, Lee S, Arslanian S 2010 Declining β-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children. Diabetes Care 33:2024-2030
15. Giannini C, Weiss R, Cali A, Bonadonna R, Santoro N, Pierpont B, Shaw M, Caprio S 2012 Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. Diabetes 61:606-614
16. Bacha F, Gungor N, Lee S, Arslanian SA 2009 In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes? Diabetes Care 32:100-105
17. Tanner JM 1981 Growth and maturation during adolescence. Nutr Rev 39:43-55
18. Tfayli H, Bacha F, Gungor N, Arslanian S 2009 Phenotypic type 2 diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus -positive patients. Diabetes 58:738-744
19. Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP 2010 Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 18:1695-1700
20. Unger RH 1995 Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870
21. Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA 2011 A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab 96:775-781
22. Lenaers E, De Feyter HM, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers JJ, Hesselink MK 2010 Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats. Obesity (Silver Spring) 18:1100-1107
23. Zeng M, Liang Y, Li H, Wang M, Wang B, Chen X, Zhou N, Cao D, Wu J 2010 Plasma metabolic fingerprinting of childhood obesity by GC/MS in conjunction with multivariate statistical analyses. J Pharm Biomed Anal 52:265-472
24. Arslanian SA, Kalhan SC 1996 Protein turnover during puberty in normal children. Am J Physiol 270:E79-E84