Cyclic AMP mimics the anti-ageing effects of calorie restriction by up-regulating sirtuin

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Zhuoran ^a   Zhang, Lu ^a   Liang, Yaru ^a   Zhang, Chi ^a   Xu, Zhiyu ^a   Zhang, Lang ^a   Fuji, Ryosuke ^a,b   Mu, Wei ^a   Li, Liyuan ^a   Jiang, Junjun ^a   Ju, Yong ^c   Wang, Zhao ^a  

^a Tsinghua University   (China)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; SIRTUIN; SIRTUIN 1; SIRTUIN 3;

ADIPOSE TISSUE; AGING; ANIMAL; BIOLOGICAL MODEL; CALORIC RESTRICTION; CELL AGING; DROSOPHILA MELANOGASTER; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; OXIDATIVE STRESS; PHENOTYPE; UPREGULATION;

ADIPOSE TISSUE; AGING; ANIMALS; CALORIC RESTRICTION; CELL AGING; CYCLIC AMP; DROSOPHILA MELANOGASTER; MICE; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PHENOTYPE; SIRTUIN 1; SIRTUIN 3; SIRTUINS; UP-REGULATION;

EID: 84936804890     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12012     Document Type: Article

References (23)

1. Lee, C. K., Klopp, R. Gj., Weindruch, R. & Prolla, T. A. Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390-1393, doi: 7785 (1999).
2. Pearson, K. J. et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8, 157-168, doi: 10.1016/j.cmet.2008.06.011 (2008).
3. Park, S. J. et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433, doi: S0092-8674 (12) 00030-X10.1016/j.cell.2012.01.017 (2012).
4. Tong, J. J., Schriner, S. E., McCleary, D., Day, B. J. & Wallace, D. C. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet 39, 476-485, doi:10.1038/ng2004 (2007).
5. Baur, J. A. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342, doi: 10.1038/nature05354 (2006).
6. Fusco, S. et al. A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci USA 109, 621-626, doi: 10.1073/pnas.1109237109 (2012).
7. Gerhart-Hines, Z. et al. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+ ). Mol Cell 44, 851-863, doi: 10.1016/j.molcel.2011.12.005 (2011).
8. Xiaolei, X. et al. Calorie restriction reduce oxidative stress by SIRT3 mediated SOD2 activation. Cell Metab 12, 662-667, doi: 10.1016/j.cmet.2010.11.015 (2010).
9. Brown, K. et al. SIRT3 Reverses aging-associated degeneration. Cell Rep 3, 319-327, doi: 10.1016/j.celrep.2013.01.005 (2013).
10. Acin-Perez, R. et al. Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab 9, 265-276, doi: 10.1016/j.cmet.2009.01.012 (2009).
11. Rakugi, H. et al. Anti-oxidative effect of Klotho on endothelial cells through cAMP activation. Endocrine 31, 82-87, doi: ENDO:31:1:82 (2007).
12. Chin, J. H., Hiremath, A. N. & Hoffman, B. B. cAMP signaling mechanisms with aging in rats. Mech Ageing Dev 86, 11-26 (1996).
13. Wolman, M. A. et al. Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1. Cell Rep 8, 1265-1270, doi: 10.1016/j.celrep.2014.07.054 (2014).
14. Balaban, R. S., Nemoto, S. & Finkel, T. Mitochondria, oxidants, and aging. Cell 120, 483-495, doi: 10.1016/j.cell.2005.02.001 (2005).
15. Selawry, H., Gutman, R., Fink, G. & Recant, L. The effect of starvation on tissue adenosine 3'-5' monophosphate levels. Biochem Biophys Res Commun 51, 198-204, doi: 0006-291X(73)90528-7 (1973).
16. Finkel, T., Deng, C. X. & Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591, doi: 10.1038/Nature08197 (2009).
17. Eriko, M. et al. Sirt6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496, doi: 10.1038/nature06736 (2008).
18. Pablo, J. F. et al. Muscle or liver specific Sirt3 deficiency induce hyperacetylase of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep 2, 425, doi: 10.1038/srep. 00425 (2012).
19. Hakimi, P. et al. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. Journal of Biological Chemistry 282, 32844-32855, doi: 10.1074/jbc.M706127200 (2007).
20. Okada-Iwabu, M. et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493-+ , doi: 10.1038/Nature12656 (2013).
21. Oestreich, E. A. et al. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. J Biol Chem 284, 1514-1522, doi: 10.1074/jbc.M806994200 (2009).
22. Fulco, M. et al. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 14, 661-673, doi: 10.1016/j.devcel.2008.02.004 (2008).
23. Rondinone, C. M. et al. Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor. Journal of Biological Chemistry 275, 10093-10098, doi: 10.1074/jbc.275.14.10093 (2000).