Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster

Nature Genetics

Volumn 39, Issue 4, 2007, Pages 476-485

  Tong, James Jiayuan ^a   Schriner, Samuel E ^a   McCleary, David ^a   Day, Brian J ^b   Wallace, Douglas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; ANTIOXIDANT; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; GENE PRODUCT; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; METALLOPORPHYRIN; NEUROFIBROMATOSIS 1 PROTEIN; NEUROFIBROMIN; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG MECHANISM; FEMALE; FERTILITY; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; HEAT STRESS; LIFESPAN; LONGEVITY; MALE; MITOCHONDRIAL RESPIRATION; MUTANT; NEUROFIBROMATOSIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRODUCTION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIOXIDANTS; CYCLIC AMP; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION REGULATION; LONGEVITY; MALE; METALLOPORPHYRINS; MITOCHONDRIA; MODELS, BIOLOGICAL; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; PHENOTYPE; REACTIVE OXYGEN SPECIES;

DROSOPHILA MELANOGASTER;

EID: 34047151226     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng2004     Document Type: Article

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