cAMP signaling mechanisms with aging in rats

Mechanisms of Ageing and Development

Volumn 86, Issue 1, 1996, Pages 11-26

  Chin, Jane H ^a   Hiremath, Anand N ^a   Hoffman, Brian B ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; B adrenergic receptors; G proteins; Vascular relaxation

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; PERTUSSIS TOXIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; HEART; HYPOTHESIS; IMMUNOBLOTTING; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION; SODIUM RESTRICTION; SPECIES DIFFERENCE;

EID: 0030019677     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(95)01676-7     Document Type: Article

References (33)

1. E.G. Lakatta, Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev., 73 (1993) 413-467.
2. R. Marcus and D. Gonzales, Age-related change in parathyroid hormone-dependent cyclic AMP formation in rat kidney. Mech. Ageing Devel., 20 (1982) 353-360.
3. H. Hanai, C.T. Liang, L. Cheng and B. Sacktor. Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity. J. Clin. Invest., 83 (1989) 268-277.
4. H.Y.-M. Pan, B.B. Hoffman, R.A. Persche and T.F. Blaschke, Decline in β-adrenergic receptor-mediated vascular relaxation with aging in man. J. Pharmacol. Exp. Ther., 239 (1986) 802-807.
5. G. Tsujimoto, C.-H. Lee and B.B. Hoffman, Age-related decrease in B-adrenergic receptor-mediated vascular smooth muscle relaxation. J. Pharmacol. Exp. Ther., 239 (1986) 411-415.
6. T.A. Deisher, S. Mankani, and B.B. Hoffman, Role of cyclic AMP-dependent protein kinase in the diminished β-adrenergic responsiveness of vascular smooth muscle with increasing age. J. Pharmacol. Exp. Ther., 249 (1989) 812-819.
7. J.R. Docherty, Cardiovascular responses in ageing: A review. Pharm. Rev., 42 (1990) 103-125.
8. J.H. Chin and B.B. Hoffman, Age-related deficit in β-receptor stimulation of cAMP binding in blood vessels. Mech. Ageing Dev., 53 (1990) 111-125.
9. S.R. O'Donnell and J.C. Wanstall, Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by β-adrenoceptor subtypes can be differentially regulated. Br. J. Pharmacol., 88 (1986) 41-49.
10. M.G. Kazanietz and M.A. Enero, Desensitization of the β-2 adrenoceptor-mediated vasodilation in rat aorta after prolonged treatment with the β-2 adrenoceptor agonist clenbuterol. J. Pharm. Exp. Ther., 252 (1990) 758-764.
11. M.I. Simon, M.P. Strathmann, and N. Gautam, Diversity of G proteins in signal transduction. Science, 252 (1991) 802-808.
12. R. Taussig and A.G. Gilman, Mammalian membrane-bound adenylyl cyclases. J. Biol. Chem., 270 (1995) 1-4.
13. R.D. Feldman, A low-sodium diet corrects the defect in β-adrenergic response in older subjects. Circulation, 85 (1992) 612-618.
14. G.L. Peterson, A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem., 83 (1977) 346-356.
15. J.J. Witt and R. Roskoski, Rapid protein kinase assay using phosphocellulose-paper absorption. Anal. Biochem., 66 (1975) 253-258.
16. J. Van de Voorde and I. Leusen, Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine. Eur. J. Pharmacol., 87 (1983) 113-120.
17. R.D. Tanz, K.S.K. Chang and T.S. Weller, Histamine relaxation of aortic rings from diabetic rats. Agents and Actions, 28 (1989) 1-8.
18. B.B. Hoffman, H. Chang, Z. Farahbakhsh and G. Reaven, Inhibition of lipolysis by adenosine is potentiated with age. J. Clin. Invest., 74 (1984) 1750-1755.
19. B.B. Hoffman, H. Chang, Z. Farahbakhsh and G.M. Reaven, Age-related decrement in hormone-stimulated lipolysis. Am. J. Physiol., 247 (1984) E772-E777.
20. K. Urasawa, T. Murakami and H. Yasuda, Age-related alterations in adenylyl cyclase system of rat hearts. Jap. Circ. J., 55 (1991) 676-684.
21. Y. Shu and P.J. Scarpace, Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging. J. Cardiovasc. Pharmacol., 23 (1994) 188-193.
22. ix-proteins in rat heart. Biochem. Pharmacol., 48 (1994) 479-486.
23. K. Tobise, Y. Ishikawa, S.R. Holmer, M.-J. Im, J.B. Newell, H. Yoshie, M. Fujita, E.E. Susannie and C.J. Homey, Changes in Type VI adenylyl cyclase isoform expression correlate with a decreased capacity for cAMP generation in the aging ventricle. Circ. Res., 74 (1994) 596-603.
24. R.F. Furchgott and P.M. Vanhoutte, Endothelium-derived relaxing and contracting factors. Fed. Am. Soc. Exp. Biol. J., 3 (1989) 2007-2018.
25. L.J. Ignarro, Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev. Pharmacol. Toxicol., 30 (1990) 535-560.
26. R.M. Rapoport and F. Murad, Role of cGMP in endothelium-dependent relaxation of vascular smooth muscle. In P.M. Vanhoutte (ed.), Relaxing and Contracting Factors, Humana Press, Clifton, NJ, 1988, pp. 219-239.
27. s-regulated adenylyl cyclases. In B.L. Brown and P.R.M. Dobson (eds.), Advances in Second Messenger and Phophoprotein Research, Vol. 28, Ravens Press, New York, 1993, pp. 27-36.
28. M.D. Johnson, Y. Zhou, E. Friedman, and J. Roberts, Expression of G protein x subunits in the aging cardiovascular system. J. Gerontology, 50A (1995) 814-819.
29. M.G. Kazanietz and M.A. Enero, Decreased β-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein. Eur. J. Pharmacol., 198 (1991) 177-181.
30. A.G. Gilman, G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem., 56 (1987) 615-649.
31. M. White, R. Roden, W. Minobe, F. Khan, P. Larrabee, M. Wollmering, J.D. Port, F. Anderson, D. Campbell, A.M. Feldman and M.R. Bristow, Age-related changes in β-adrenergic neuroeffector systems in the human heart. Circulation, 90 (1994) 1225-1238.
32. sx protein mRNA in rat ventricular myocardium with aging. Eur. J. Pharmacol., 266 (1994) 147-154.
33. s protein expression may impair adenylate cyclase activation in old kidneys. Am. J. Physiol., 264 (1993) F770-F773.