Optimized quantification of translocator protein radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers

Journal of Nuclear Medicine

Volumn 56, Issue 7, 2015, Pages 1048-1054

  Lavisse, Sonia ^a,b   García Lorenzo, Daniel ^b,c   Peyronneau, Marie Anne ^d   Bodini, Benedetta ^b,c,d,e   Thiriez, Claire ^a,b,f   Kuhnast, Bertrand ^d   Comtat, Claude ^d   Remy, Philippe ^a,b,f,g   Stankoff, Bruno ^b,c   Bottlaender, Michel ^d,h  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b CNRS   (France)

^c INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^d SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f HENRI MONDOR HOSPITAL   (France)

^g UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^h SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

18F DPA 714; Genotyped human; PET; Quantification; TSPO

Indexed keywords

CARRIER PROTEIN; N,N DIETHYL 2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE 3 ACETAMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; FLUORINE; LIGAND; N,N-DIETHYL-2-(2-(4-(2-FLUOROETHOXY)PHENYL)-5,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-3-YL)ACETAMIDE; PROTEIN BINDING; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; ARTERIAL BLOOD; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TARGETING; FEMALE; FRONTAL CORTEX; GENE; GENE EXPRESSION; GENE LOCATION; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; IMAGING SOFTWARE; IMAGING SYSTEM; INTERMETHOD COMPARISON; MALE; NEUROIMAGING; NORMAL HUMAN; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PUTAMEN; RADIOACTIVITY; TEMPORAL CORTEX; THALAMUS; TSPO GENE; VENOUS BLOOD; VOLUME OF DISTRIBUTION; WHITE MATTER; BRAIN; CHEMISTRY; DEGENERATIVE DISEASE; GENETIC POLYMORPHISM; IMAGE PROCESSING; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY; SCINTISCANNING;

ADULT; BRAIN; CEREBELLUM; FEMALE; FLUORINE RADIOISOTOPES; GENOTYPE; HEALTHY VOLUNTEERS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; LIGANDS; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; POLYMORPHISM, GENETIC; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRAZOLES; PYRIMIDINES; RECEPTORS, GABA; THALAMUS;

EID: 84936802476     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.115.156083     Document Type: Article

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