Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

Cardiovascular Research

Volumn 107, Issue 1, 2015, Pages 108-118

  Wang, Jian ^a,b   Fu, Xin ^a   Yang, Kai ^a,b   Jiang, Qian ^a   Chen, Yuqin ^a   Jia, Jing ^a   Duan, Xin ^c   Wang, Elizabeth W ^d   He, Jianxing ^a   Ran, Pixin ^a   Zhong, Nanshan ^a   Semenza, Gregg L ^e   Lu, Wenju ^a,b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d GEISINGER MEDICAL CENTER   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Basal Ca2+ i; BMP4; HIF 1; PASMCs; TRPC

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CALCIUM ION; HYPOXIA INDUCIBLE FACTOR 1; NOGGIN; OXYGEN; PROTEIN; SMAD1 PROTEIN; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CANONICAL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; BMP4 PROTEIN, HUMAN; CALCIUM; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY C, MEMBER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; BMP4 GENE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GENE SILENCING; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HETEROZYGOTE; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; MUTANT MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PULMONARY ARTERY SMOOTH MUSCLE CELL; RAT; UPREGULATION; WILD TYPE; ANIMAL; CYTOLOGY; GENETICS; HYPERTENSION, PULMONARY; METABOLISM; PHYSIOLOGY; PULMONARY ARTERY; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CALCIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PULMONARY ARTERY; RATS; SMAD1 PROTEIN; TRPC CATION CHANNELS; UP-REGULATION;

EID: 84936767676     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv122     Document Type: Article

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