Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension

Experimental Biology and Medicine

Volumn 235, Issue 7, 2010, Pages 805-813

  Murakami, Koko ^a   Mathew, Rajamma ^a   Huang, Jing ^a   Farahani, Reza ^a   Peng, Hong ^a   Olson, Susan C ^a   Etlinger, Joseph D ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Animal model; BMPR II; Pulmonary arterial hypertension; SMAD7; Smurf1 ubiquitin ligase; Vascular remodeling

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; MONOCROTALINE; PROTEASOME INHIBITOR; PROTEIN SMURF1; SMAD7 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISEASE MODEL; HUMAN; HUMAN CELL; HYPOXIA; LYSOSOME; MALE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; STEADY STATE; UBIQUITINATION;

ANIMALS; ANOXIA; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN RECEPTORS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME INDUCTION; HYPERTENSION, PULMONARY; LUNG; MALE; MICE; MONOCROTALINE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SMAD7 PROTEIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

ANIMALIA; MUS; RATTUS;

EID: 77953797876     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2010.009383     Document Type: Article

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