Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells

Toxicology in Vitro

Volumn 29, Issue 7, 2015, Pages 1358-1368

  Chang, Yo Chen ^a,b   Hsieh, Ming Chu ^a   Wu, Horng Jiun ^a,b   Wu, Wen Chuan ^a   Kao, Ying Hsien ^c,d  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c E DA HOSPITAL   (Taiwan)

^d FOOYIN UNIVERSITY   (Taiwan)

Author keywords

Age related macular degeneration; Autophagosomes; Autophagy flux; Methylglyoxal; Reactive oxygen species; Signal transduction

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE INHIBITOR; AMINOGUANIDINE; BAFILOMYCIN A; CHLOROQUINE; HYDROGEN PEROXIDE; METHYLGLYOXAL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

AGE RELATED MACULAR DEGENERATION; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GROWTH INHIBITION; GROWTH RATE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; MACULAR DEGENERATION; METABOLISM; RETINAL PIGMENT EPITHELIUM;

AUTOPHAGY; CELL LINE; CELL PROLIFERATION; EPITHELIAL CELLS; GLUCOSE; HUMANS; HYDROGEN PEROXIDE; MACULAR DEGENERATION; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVALDEHYDE; RETINAL PIGMENT EPITHELIUM;

EID: 84936752198     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.05.014     Document Type: Article

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