Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid

Free Radical Biology and Medicine

Volumn 60, Issue , 2013, Pages 7-16

  Lee, Bao Hong ^a   Hsu, Wei Hsuan ^a   Hsu, Ya Wen ^a   Pan, Tzu Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Diabetes; Dimerumic acid; Free radicals; Methylglyoxal; Nuclear factor erythroid 2 related factor 2; Receptor for advanced glycation endproducts

Indexed keywords

ACETYLCYSTEINE; ADVANCED GLYCATION END PRODUCT; ANTIINFLAMMATORY AGENT; BOVINE SERUM ALBUMIN; DIMERUMIC ACID; GLUTATHIONE; GLYOXALASE; INTERLEUKIN 1BETA; LACTIC ACID; MESSENGER RNA; METHYLGLYOXAL; PROTEIN P47; PROTEIN S100B; SILYMARIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; DIABETES MELLITUS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS; DIKETOPIPERAZINES; GLUCOSE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; HYDROXAMIC ACIDS; INFLAMMATION; INSULIN; LACTIC ACID; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PYRUVALDEHYDE; RECEPTORS, IMMUNOLOGIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BOVINAE; MUS;

EID: 84874936335     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.01.030     Document Type: Article

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