Ras activation modulates methylglyoxal-induced mesangial cell apoptosis through superoxide production

Renal Failure

Volumn 29, Issue 7, 2007, Pages 911-921

  Huang, Wei Jan ^a   Tung, Chun Wu ^b   Ho, Cheng ^b   Yang, Jen Tsung ^b   Chen, Min Li ^a   Chang, Pey Jium ^c   Lee, Pei Hsien ^b   Lin, Chun Liang ^a,b,d   Wang, Jeng Yi ^b  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Apoptosis; Diabetes; Ras; Renal mesangial cells; Superoxide

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; LIPOCORTIN 5; MANUMYCIN; METHYLGLYOXAL; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; RAS PROTEIN; SUPEROXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MESANGIUM CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CATECHOLAMINES; CELL LINE; CELL SURVIVAL; ENZYME ACTIVATION; IMIDAZOLES; IMIDAZOLINES; IN SITU NICK-END LABELING; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYENES; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-JUN; PYRIDINES; PYRUVALDEHYDE; RAS PROTEINS; RATS; SUPEROXIDES;

EID: 36249008638     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.1080/08860220701573509     Document Type: Article

References (18)

1. Saito Y, Kida H, Takeda S, Yoshimura M, Yokoyama H, Koshino Y, Hattori N. Mesangiolysis in diabetic glomeruli: Its role in the formation of nodular lesions. Kidney Int. 1988;34:389-396.
2. Lemley KV, Abdullah I, Myers BD, Meyer TW, Blouch K, Smith WE, Bennett PH, Nelson RG. Evolution of incipient nephropathy in type 2 diabetes mellitus. Kidney Int. 2000;58:1228-1237.
3. Mishra R, Emancipator SN, Kern T, Simonson MS. High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int. 2005;67:82-93.
4. Dalla Vestra M, Saller A, Mauer M, Fioretto P. Role of mesangial expansion in the pathogenesis of diabetic nephropathy. J Nephrol. 2001;14:S51-S57.
5. Frye EB, Degenhardt TP, Thorpe SR, Baynes JW. Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins. J Biol Chem. 1998;273:18714-19719.
6. Kusunoki H, Miyata S, Ohara T, Liu BF, Uriuhara A, Kojima H, Suzuki K, Miyazaki H, Yamashita Y, Inaba K, Kasuga M. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care. 2003;26:1889-1894.
7. Fukunaga M, Miyata S, Liu BF, Miyazaki H, Hirota Y, Higo S, Hamada Y, Ueyama S, Kasuga M. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochem Biophys Res Commun. 2004;320:689-695.
8. Liu BF, Miyata S, Hirota Y, Higo S, Miyazaki H, Fukunaga M, Hamada Y, Ueyama S, Muramoto O, Uriuhara A, Kasuga M. Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells. Kidney Int. 2003;63:947-957.
9. Lin CL, Wang FS, Kuo YR, Huang YT, Huang HC, Sun YC, Kuo YH. Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney Int. 2006;69:1593-1600.
10. Qanungo S, Wang M, Nieminen AL. N-acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. J Biol Chem. 2004;279:50455-50464.
11. Bokoch GM, Der CJ. Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J. 1993;7:750-759.
12. Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem. 1997;272:17810-17814.
13. Thannickal VJ, Day RM, Klinz SG, Bastien MC, Larios JM, Fanburg BL. Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-beta1. FASEB J. 2000;14:1741-1748.
14. Seru R, Mondola P, Damiano S, Svegliati S, Agnese S, Avvedimento EV, Santillo M. HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway. J Neurochem. 2004;91:613-622.
15. Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC, Chan JYH. NADPH Oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res. 2005;97:772-780.
16. Wang FS, Wang CJ, Chen YJ, Chang PR, Huang YT, Sun YC, Huang HC, Yang YJ, Yang KD. Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wavestimulated osteoblasts. J Biol Chem. 2004;279:10331-10337.
17. Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, Ham J. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci. 1998;18:751-762.
18. Wang N, Verna L, Hardy S, Zhu Y, Ma KS, Birrer MJ, Stemerman MB. c-Jun triggers apoptosis in human vascular endothelial cells. Circ Res. 1999;85:387-393.