메뉴 건너뛰기




Volumn 34, Issue 18, 2015, Pages 2371-2384

Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine

Author keywords

[No Author keywords available]

Indexed keywords

ACK PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; ONCOPROTEIN; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; SRC42A PROTEIN, DROSOPHILA; SRC64B PROTEIN, DROSOPHILA; STAT PROTEIN; STAT92E PROTEIN, DROSOPHILA;

EID: 84936120034     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.163     Document Type: Article
Times cited : (37)

References (99)
  • 2
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004; 4: 470-480.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 3
    • 0025192786 scopus 로고
    • Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
    • Cartwright CA, Meisler AI, Eckhart W. Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc Natl Acad Sci USA 1990; 87: 558-562.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 558-562
    • Cartwright, C.A.1    Meisler, A.I.2    Eckhart, W.3
  • 4
    • 0031025529 scopus 로고    scopus 로고
    • A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer
    • Brunton VG, Ozanne BW, Paraskeva C, Frame MC. A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene 1997; 14: 283-293.
    • (1997) Oncogene , vol.14 , pp. 283-293
    • Brunton, V.G.1    Ozanne, B.W.2    Paraskeva, C.3    Frame, M.C.4
  • 5
    • 0142092607 scopus 로고    scopus 로고
    • A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila
    • Stewart RA, Li DM, Huang H, Xu T. A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene 2003; 22: 6436-6444.
    • (2003) Oncogene , vol.22 , pp. 6436-6444
    • Stewart, R.A.1    Li, D.M.2    Huang, H.3    Xu, T.4
  • 6
    • 3242700398 scopus 로고    scopus 로고
    • Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src Jun N-terminal kinase, and STAT pathways
    • Read RD, Bach EA, Cagan RL. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol 2004; 24: 6676-6689.
    • (2004) Mol Cell Biol , vol.24 , pp. 6676-6689
    • Read, R.D.1    Bach, E.A.2    Cagan, R.L.3
  • 7
    • 2942722677 scopus 로고    scopus 로고
    • Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis
    • Pedraza LG, Stewart RA, Li DM, Xu T. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Oncogene 2004; 23: 4754-4762.
    • (2004) Oncogene , vol.23 , pp. 4754-4762
    • Pedraza, L.G.1    Stewart, R.A.2    Li, D.M.3    Xu, T.4
  • 8
    • 29744462234 scopus 로고    scopus 로고
    • Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis
    • Vidal M, Larson DE, Cagan RL. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell 2006; 10: 33-44.
    • (2006) Dev Cell , vol.10 , pp. 33-44
    • Vidal, M.1    De, L.2    Cagan, R.L.3
  • 9
    • 35948935013 scopus 로고    scopus 로고
    • Differing Src signaling levels have distinct outcomes in Drosophila
    • Vidal M, Warner S, Read R, Cagan RL. Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Res 2007; 67: 10278-10285.
    • (2007) Cancer Res , vol.67 , pp. 10278-10285
    • Vidal, M.1    Warner, S.2    Read, R.3    Cagan, R.L.4
  • 10
    • 84871924181 scopus 로고    scopus 로고
    • Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila
    • Enomoto M, Igaki T. Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. EMBO Rep 2013; 14: 65-72.
    • (2013) EMBO Rep , vol.14 , pp. 65-72
    • Enomoto, M.1    Igaki, T.2
  • 11
    • 84899417132 scopus 로고    scopus 로고
    • Drosophila actin-capping protein limits JNK activation by the Src proto-oncogene
    • Fernandez BG, Jezowska B, Janody F. Drosophila actin-capping protein limits JNK activation by the Src proto-oncogene. Oncogene 2013; 33: 2027-39.
    • (2013) Oncogene , vol.33 , pp. 2027-2039
    • Fernandez, B.G.1    Jezowska, B.2    Janody, F.3
  • 12
    • 0033522510 scopus 로고    scopus 로고
    • Src family kinases are required for integrin but not PDGFR signal transduction
    • Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 1999; 18: 2459-2471.
    • (1999) EMBO J , vol.18 , pp. 2459-2471
    • Klinghoffer, R.A.1    Sachsenmaier, C.2    Cooper, J.A.3    Soriano, P.4
  • 13
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein B, Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006; 439: 470-474.
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 14
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006; 439: 475-479.
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 15
    • 58049218983 scopus 로고    scopus 로고
    • Tissue damage-induced intestinal stem cell division in Drosophila
    • Amcheslavsky A, Jiang J, Ip YT. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 2009; 4: 49-61.
    • (2009) Cell Stem Cell , vol.4 , pp. 49-61
    • Amcheslavsky, A.1    Jiang, J.2    Ip, Y.T.3
  • 16
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 2009; 23: 2333-2344.
    • (2009) Genes Dev , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 17
    • 67650831470 scopus 로고    scopus 로고
    • Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection
    • Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 2009; 325: 340-343.
    • (2009) Science , vol.325 , pp. 340-343
    • Cronin, S.J.1    Nehme, N.T.2    Limmer, S.3    Liegeois, S.4    Pospisilik, J.A.5    Schramek, D.6
  • 18
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • Biteau B, Hochmuth CE, Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 2008; 3: 442-455.
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 19
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 2009; 137: 1343-1355.
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5    Edgar, B.A.6
  • 20
    • 69549113488 scopus 로고    scopus 로고
    • Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
    • Lee WC, Beebe K, Sudmeier L, Micchelli CA. Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 2009; 136: 2255-2264.
    • (2009) Development , vol.136 , pp. 2255-2264
    • Lee, W.C.1    Beebe, K.2    Sudmeier, L.3    Micchelli, C.A.4
  • 21
    • 73949145172 scopus 로고    scopus 로고
    • Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
    • Apidianakis Y, Pitsouli C, Perrimon N, Rahme L. Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci USA 2009; 106: 20883-20888.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20883-20888
    • Apidianakis, Y.1    Pitsouli, C.2    Perrimon, N.3    Rahme, L.4
  • 22
    • 33847168133 scopus 로고    scopus 로고
    • Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    • Ohlstein B, Spradling A. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 2007; 315: 988-992.
    • (2007) Science , vol.315 , pp. 988-992
    • Ohlstein, B.1    Spradling, A.2
  • 23
    • 0028879873 scopus 로고
    • Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
    • Barone MV, Courtneidge SA. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature 1995; 378: 509-512.
    • (1995) Nature , vol.378 , pp. 509-512
    • Barone, M.V.1    Courtneidge, S.A.2
  • 24
    • 0029093295 scopus 로고
    • Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division
    • Roche S, Fumagalli S, Courtneidge SA. Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division. Science 1995; 269: 1567-1569.
    • (1995) Science , vol.269 , pp. 1567-1569
    • Roche, S.1    Fumagalli, S.2    Courtneidge, S.A.3
  • 25
    • 0034627767 scopus 로고    scopus 로고
    • Src family tyrosine kinases and growth factor signaling
    • Abram CL, Courtneidge SA. Src family tyrosine kinases and growth factor signaling. Exp Cell Res 2000; 254: 1-13.
    • (2000) Exp Cell Res , vol.254 , pp. 1-13
    • Abram, C.L.1    Courtneidge, S.A.2
  • 26
    • 33644545050 scopus 로고    scopus 로고
    • Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition
    • Prathapam T, Tegen S, Oskarsson T, Trumpp A, Martin GS. Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition. Proc Natl Acad Sci USA 2006; 103: 2695-2700.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2695-2700
    • Prathapam, T.1    Tegen, S.2    Oskarsson, T.3    Trumpp, A.4    Martin, G.S.5
  • 27
    • 33846268807 scopus 로고    scopus 로고
    • P27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    • Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S et al. P27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007; 128: 281-294.
    • (2007) Cell , vol.128 , pp. 281-294
    • Chu, I.1    Sun, J.2    Arnaout, A.3    Kahn, H.4    Hanna, W.5    Narod, S.6
  • 28
    • 4544235743 scopus 로고    scopus 로고
    • C-Src and cooperating partners in human cancer
    • Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell 2004; 6: 209-214.
    • (2004) Cancer Cell , vol.6 , pp. 209-214
    • Ishizawar, R.1    Parsons, S.J.2
  • 29
    • 84875063573 scopus 로고    scopus 로고
    • Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells
    • Sotillos S, Krahn M, Espinosa-Vazquez JM, Hombria JC. Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development 2013; 140: 1507-1516.
    • (2013) Development , vol.140 , pp. 1507-1516
    • Sotillos, S.1    Krahn, M.2    Espinosa-Vazquez, J.M.3    Hombria, J.C.4
  • 30
    • 73549097743 scopus 로고    scopus 로고
    • JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    • Beebe K, Lee WC, Micchelli CA. JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol 2010; 338: 28-37.
    • (2010) Dev Biol , vol.338 , pp. 28-37
    • Beebe, K.1    Lee, W.C.2    Micchelli, C.A.3
  • 31
    • 78650977190 scopus 로고    scopus 로고
    • EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
    • Jiang H, Grenley MO, Bravo MJ, Blumhagen RZ, Edgar BA. EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 2011; 8: 84-95.
    • (2011) Cell Stem Cell , vol.8 , pp. 84-95
    • Jiang, H.1    Grenley, M.O.2    Bravo, M.J.3    Blumhagen, R.Z.4    Edgar, B.A.5
  • 32
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13: 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 33
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
    • Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5: 200-211.
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 34
    • 84867363816 scopus 로고    scopus 로고
    • The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells
    • Goulas S, Conder R, Knoblich JA. The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell 2012; 11: 529-540.
    • (2012) Cell Stem Cell , vol.11 , pp. 529-540
    • Goulas, S.1    Conder, R.2    Knoblich, J.A.3
  • 35
    • 80052700259 scopus 로고    scopus 로고
    • Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
    • Perdigoto CN, Schweisguth F, Bardin AJ. Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 2011; 138: 4585-4595.
    • (2011) Development , vol.138 , pp. 4585-4595
    • Perdigoto, C.N.1    Schweisguth, F.2    Bardin, A.J.3
  • 36
    • 78649439321 scopus 로고    scopus 로고
    • Asymmetric cell division: Recent developments and their implications for tumour biology
    • Knoblich JA. Asymmetric cell division: Recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 2010; 11: 849-860.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 849-860
    • Knoblich, J.A.1
  • 37
    • 0035861891 scopus 로고    scopus 로고
    • A prize for proliferation
    • Nasmyth K. A prize for proliferation. Cell 2001; 107: 689-701.
    • (2001) Cell , vol.107 , pp. 689-701
    • Nasmyth, K.1
  • 38
    • 0141706827 scopus 로고    scopus 로고
    • Cell cycle-dependent and cell cycleindependent control of transcription by the Drosophila E2F/RB pathway
    • Dimova DK, Stevaux O, Frolov MV, Dyson NJ. Cell cycle-dependent and cell cycleindependent control of transcription by the Drosophila E2F/RB pathway. Genes Dev 2003; 17: 2308-2320.
    • (2003) Genes Dev , vol.17 , pp. 2308-2320
    • Dimova, D.K.1    Stevaux, O.2    Frolov, M.V.3    Dyson, N.J.4
  • 39
    • 49849098630 scopus 로고    scopus 로고
    • Regulation of APC/C activators in mitosis and meiosis
    • Pesin JA, Orr-Weaver TL. Regulation of APC/C activators in mitosis and meiosis. Annu Rev Cell Dev Biol 2008; 24: 475-499.
    • (2008) Annu Rev Cell Dev Biol , vol.24 , pp. 475-499
    • Pesin, J.A.1    Orr-Weaver, T.L.2
  • 40
    • 34047097318 scopus 로고    scopus 로고
    • A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila
    • Buttitta LA, Katzaroff AJ, Perez CL, de la Cruz A, Edgar BA. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell 2007; 12: 631-643.
    • (2007) Dev Cell , vol.12 , pp. 631-643
    • Buttitta, L.A.1    Katzaroff, A.J.2    Perez, C.L.3    De La Cruz, A.4    Edgar, B.A.5
  • 41
    • 57049097607 scopus 로고    scopus 로고
    • Intrinsic negative cell cycle regulation provided by PIP box-and Cul4Cdt2-mediated destruction of E2f1 during S phase
    • Shibutani ST, de la Cruz AF, Tran V, Turbyfill WJ 3rd, Reis T, Edgar BA et al. Intrinsic negative cell cycle regulation provided by PIP box-and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell 2008; 15: 890-900.
    • (2008) Dev Cell , vol.15 , pp. 890-900
    • Shibutani, S.T.1    De La Cruz, A.F.2    Tran, V.3    Turbyfill, W.J.4    Reis, T.5    Edgar, B.A.6
  • 42
    • 77953577596 scopus 로고    scopus 로고
    • A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo
    • Buttitta LA, Katzaroff AJ, Edgar BA. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol 2010; 189: 981-996.
    • (2010) J Cell Biol , vol.189 , pp. 981-996
    • Buttitta, L.A.1    Katzaroff, A.J.2    Edgar, B.A.3
  • 43
    • 84864121296 scopus 로고    scopus 로고
    • Regulation of Ack-family nonreceptor tyrosine kinases
    • Prieto-Echague V, Miller WT. Regulation of Ack-family nonreceptor tyrosine kinases. J Signal Transd 2011; 2011: 742372.
    • (2011) J Signal Transd , vol.2011 , pp. 742372
    • Prieto-Echague, V.1    Miller, W.T.2
  • 44
    • 0036091383 scopus 로고    scopus 로고
    • ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster
    • Sem KP, Zahedi B, Tan I, Deak M, Lim L, Harden N. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Mol Cell Biol 2002; 22: 3685-3697.
    • (2002) Mol Cell Biol , vol.22 , pp. 3685-3697
    • Sem, K.P.1    Zahedi, B.2    Tan, I.3    Deak, M.4    Lim, L.5    Harden, N.6
  • 46
    • 84877922745 scopus 로고    scopus 로고
    • Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis
    • Abdallah AM, Zhou X, Kim C, Shah KK, Hogden C, Schoenherr JA et al. Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis. Dev Biol 2013; 378: 141-153.
    • (2013) Dev Biol , vol.378 , pp. 141-153
    • Abdallah, A.M.1    Zhou, X.2    Kim, C.3    Shah, K.K.4    Hogden, C.5    Schoenherr, J.A.6
  • 47
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    • Jiang H, Edgar BA. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 2009; 136: 483-493.
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 48
    • 78650397479 scopus 로고    scopus 로고
    • Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
    • Buchon N, Broderick NA, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 2010; 8: 152.
    • (2010) BMC Biol , vol.8 , pp. 152
    • Buchon, N.1    Broderick, N.A.2    Kuraishi, T.3    Lemaitre, B.4
  • 49
    • 43449097534 scopus 로고    scopus 로고
    • Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
    • Choi NH, Kim JG, Yang DJ, Kim YS, Yoo MA. Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 2008; 7: 318-334.
    • (2008) Aging Cell , vol.7 , pp. 318-334
    • Choi, N.H.1    Kim, J.G.2    Yang, D.J.3    Kim, Y.S.4    Yoo, M.A.5
  • 50
    • 43049151801 scopus 로고    scopus 로고
    • Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis
    • Shindo M, Wada H, Kaido M, Tateno M, Aigaki T, Tsuda L et al. Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis. Development 2008; 135: 1355-1364.
    • (2008) Development , vol.135 , pp. 1355-1364
    • Shindo, M.1    Wada, H.2    Kaido, M.3    Tateno, M.4    Aigaki, T.5    Tsuda, L.6
  • 51
    • 0029121267 scopus 로고
    • Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers
    • Maa MC, Leu TH, McCarley DJ, Schatzman RC, Parsons SJ. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers. Proc Natl Acad Sci USA 1995; 92: 6981-6985.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6981-6985
    • Maa, M.C.1    Leu, T.H.2    McCarley, D.J.3    Schatzman, R.C.4    Parsons, S.J.5
  • 52
    • 0022472990 scopus 로고
    • Requirement for c-ras proteins during viral oncogene transformation
    • Smith MR, DeGudicibus SJ, Stacey DW. Requirement for c-ras proteins during viral oncogene transformation. Nature 1986; 320: 540-543.
    • (1986) Nature , vol.320 , pp. 540-543
    • Smith, M.R.1    Degudicibus, S.J.2    Stacey, D.W.3
  • 53
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Srctransformed cell lines
    • Cao X, Tay A, Guy GR, Tan YH. Activation and association of Stat3 with Src in v-Srctransformed cell lines. Mol Cell Biol 1996; 16: 1595-1603.
    • (1996) Mol Cell Biol , vol.16 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 54
    • 0033546315 scopus 로고    scopus 로고
    • ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
    • Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem 1999; 274: 17209-17218.
    • (1999) J Biol Chem , vol.274 , pp. 17209-17218
    • Olayioye, M.A.1    Beuvink, I.2    Horsch, K.3    Daly, J.M.4    Hynes, N.E.5
  • 55
    • 84870044742 scopus 로고    scopus 로고
    • Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut
    • Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development 2012; 139: 4524-4535.
    • (2012) Development , vol.139 , pp. 4524-4535
    • Cordero, J.B.1    Stefanatos, R.K.2    Myant, K.3    Vidal, M.4    Sansom, O.J.5
  • 56
    • 0347986681 scopus 로고    scopus 로고
    • MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development
    • Kim M, Cha GH, Kim S, Lee JH, Park J, Koh H et al. MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Mol Cell Biol 2004; 24: 573-583.
    • (2004) Mol Cell Biol , vol.24 , pp. 573-583
    • Kim, M.1    Cha, G.H.2    Kim, S.3    Lee, J.H.4    Park, J.5    Koh, H.6
  • 57
    • 0035975940 scopus 로고    scopus 로고
    • Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless
    • Brown S, Hu N, Hombria JC. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr Biol 2001; 11: 1700-1705.
    • (2001) Curr Biol , vol.11 , pp. 1700-1705
    • Brown, S.1    Hu, N.2    Hombria, J.C.3
  • 59
    • 0028109854 scopus 로고
    • Transcriptional regulation of string (cdc25): A link between developmental programming and the cell cycle
    • Edgar BA, Lehman DA, O'Farrell PH. Transcriptional regulation of string (cdc25): A link between developmental programming and the cell cycle. Development 1994; 120: 3131-3143.
    • (1994) Development , vol.120 , pp. 3131-3143
    • Edgar, B.A.1    Lehman, D.A.2    O'Farrell, P.H.3
  • 60
    • 0032568795 scopus 로고    scopus 로고
    • Coordination of growth and cell division in the Drosophila wing
    • Neufeld TP, de la Cruz AF, Johnston LA, Edgar BA. Coordination of growth and cell division in the Drosophila wing. Cell 1998; 93: 1183-1193.
    • (1998) Cell , vol.93 , pp. 1183-1193
    • Neufeld, T.P.1    De La Cruz, A.F.2    Johnston, L.A.3    Edgar, B.A.4
  • 61
    • 1942485888 scopus 로고    scopus 로고
    • Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
    • Reis T, Edgar BA. Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Cell 2004; 117: 253-264.
    • (2004) Cell , vol.117 , pp. 253-264
    • Reis, T.1    Edgar, B.A.2
  • 62
    • 17044426255 scopus 로고    scopus 로고
    • When timing is everything: Role of cell cycle regulation in asymmetric division
    • Prokopenko SN, Chia W. When timing is everything: Role of cell cycle regulation in asymmetric division. Semin Cell Dev Biol 2005; 16: 423-437.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 423-437
    • Prokopenko, S.N.1    Chia, W.2
  • 63
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation
    • Orford KW, Scadden DT. Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation. Nat Rev Genet 2008; 9: 115-128.
    • (2008) Nat Rev Genet , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 64
    • 57049094374 scopus 로고    scopus 로고
    • Proliferative control in Drosophila stem cells
    • Kohlmaier A, Edgar BA. Proliferative control in Drosophila stem cells. Curr Opin Cell Biol 2008; 20: 699-706.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 699-706
    • Kohlmaier, A.1    Edgar, B.A.2
  • 65
    • 84878614163 scopus 로고    scopus 로고
    • Morphological and molecular characterization of adult midgut compartmentalization in Drosophila
    • Buchon N, Osman D, David FP, Fang HY, Boquete JP, Deplancke B et al. Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell Rep 2013; 3: 1725-1738.
    • (2013) Cell Rep , vol.3 , pp. 1725-1738
    • Buchon, N.1    Osman, D.2    David, F.P.3    Fang, H.Y.4    Boquete, J.P.5    Deplancke, B.6
  • 66
    • 84870700189 scopus 로고    scopus 로고
    • Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage
    • Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H. Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet 2012; 8: E1003045.
    • (2012) PLoS Genet , vol.8 , pp. e1003045
    • Kapuria, S.1    Karpac, J.2    Biteau, B.3    Hwangbo, D.4    Jasper, H.5
  • 67
    • 34548486689 scopus 로고    scopus 로고
    • Polo inhibits progenitor selfrenewal and regulates Numb asymmetry by phosphorylating Pon
    • Wang H, Ouyang Y, Somers WG, Chia W, Lu B. Polo inhibits progenitor selfrenewal and regulates Numb asymmetry by phosphorylating Pon. Nature 2007; 449: 96-100.
    • (2007) Nature , vol.449 , pp. 96-100
    • Wang, H.1    Ouyang, Y.2    Somers, W.G.3    Chia, W.4    Lu, B.5
  • 68
    • 0037418839 scopus 로고    scopus 로고
    • Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 2003; 113: 25-36.
    • (2003) Cell , vol.113 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 69
    • 78651499087 scopus 로고    scopus 로고
    • Characterization of midgut stem cell-and enteroblast-specific Gal4 lines in Drosophila
    • Zeng X, Chauhan C, Hou SX. Characterization of midgut stem cell-and enteroblast-specific Gal4 lines in Drosophila. Genesis 2010; 48: 607-611.
    • (2010) Genesis , vol.48 , pp. 607-611
    • Zeng, X.1    Chauhan, C.2    Hou, S.X.3
  • 71
    • 67849094224 scopus 로고    scopus 로고
    • Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary
    • Chau J, Kulnane LS, Salz HK. Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary. Genetics 2009; 182: 121-132.
    • (2009) Genetics , vol.182 , pp. 121-132
    • Chau, J.1    Kulnane, L.S.2    Salz, H.K.3
  • 72
    • 45349103036 scopus 로고    scopus 로고
    • The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles
    • Zielke N, Querings S, Rottig C, Lehner C, Sprenger F. The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles. Genes Dev 2008; 22: 1690-1703.
    • (2008) Genes Dev , vol.22 , pp. 1690-1703
    • Zielke, N.1    Querings, S.2    Rottig, C.3    Lehner, C.4    Sprenger, F.5
  • 73
    • 84861902129 scopus 로고    scopus 로고
    • Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells
    • de Navascues J, Perdigoto CN, Bian Y, Schneider MH, Bardin AJ, Martinez-Arias A et al. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. EMBO J 2012; 31: 2473-2485.
    • (2012) EMBO J , vol.31 , pp. 2473-2485
    • De Navascues, J.1    Perdigoto, C.N.2    Bian, Y.3    Schneider, M.H.4    Bardin, A.J.5    Martinez-Arias, A.6
  • 74
    • 80155123827 scopus 로고    scopus 로고
    • Altered modes of stem cell division drive adaptive intestinal growth
    • O'Brien LE, Soliman SS, Li X, Bilder D. Altered modes of stem cell division drive adaptive intestinal growth. Cell 2011; 147: 603-614.
    • (2011) Cell , vol.147 , pp. 603-614
    • O'Brien, L.E.1    Soliman, S.S.2    Li, X.3    Bilder, D.4
  • 75
    • 0037064121 scopus 로고    scopus 로고
    • ErbB-2 activates Stat3 alpha in a Src-and JAK2-dependent manner
    • Ren Z, Schaefer TS. ErbB-2 activates Stat3 alpha in a Src-and JAK2-dependent manner. J Biol Chem 2002; 277: 38486-38493.
    • (2002) J Biol Chem , vol.277 , pp. 38486-38493
    • Ren, Z.1    Schaefer, T.S.2
  • 77
    • 84864020483 scopus 로고    scopus 로고
    • Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model
    • Herranz H, Hong X, Hung NT, Voorhoeve PM, Cohen SM. Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev 2012; 26: 1602-1611.
    • (2012) Genes Dev , vol.26 , pp. 1602-1611
    • Herranz, H.1    Hong, X.2    Hung, N.T.3    Voorhoeve, P.M.4    Cohen, S.M.5
  • 78
    • 7944233465 scopus 로고    scopus 로고
    • Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis
    • Silva CM. Role of STATs as downstream signal transducers in Src family kinasemediated tumorigenesis. Oncogene 2004; 23: 8017-8023.
    • (2004) Oncogene , vol.23 , pp. 8017-8023
    • Silva, C.M.1
  • 79
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998; 18: 2545-2552.
    • (1998) Mol Cell Biol , vol.18 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 80
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell Jr JE. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994; 264: 95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 81
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 2005; 122: 421-434.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 82
    • 0036904830 scopus 로고    scopus 로고
    • Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
    • Baonza A, Murawsky CM, Travers AA, Freeman M. Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis. Nat Cell Biol 2002; 4: 976-980.
    • (2002) Nat Cell Biol , vol.4 , pp. 976-980
    • Baonza, A.1    Murawsky, C.M.2    Travers, A.A.3    Freeman, M.4
  • 83
    • 84891627773 scopus 로고    scopus 로고
    • Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling
    • Huang H, Li J, Hu L, Ge L, Ji H, Zhao Y et al. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Dev Biol 2014; 385: 211-219.
    • (2014) Dev Biol , vol.385 , pp. 211-219
    • Huang, H.1    Li, J.2    Hu, L.3    Ge, L.4    Ji, H.5    Zhao, Y.6
  • 84
    • 84883455449 scopus 로고    scopus 로고
    • Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration
    • Ren F, Shi Q, Chen Y, Jiang A, Ip YT, Jiang H et al. Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. Cell Res 2013; 23: 1133-1146.
    • (2013) Cell Res , vol.23 , pp. 1133-1146
    • Ren, F.1    Shi, Q.2    Chen, Y.3    Jiang, A.4    Ip, Y.T.5    Jiang, H.6
  • 85
    • 84860299917 scopus 로고    scopus 로고
    • Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control
    • Herranz H, Hong X, Cohen SM. Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol 2012; 22: 651-657.
    • (2012) Curr Biol , vol.22 , pp. 651-657
    • Herranz, H.1    Hong, X.2    Cohen, S.M.3
  • 86
    • 44649171784 scopus 로고    scopus 로고
    • A wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing
    • Herranz H, Perez L, Martin FA, Milan M. A wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing. EMBO J 2008; 27: 1633-1645.
    • (2008) EMBO J , vol.27 , pp. 1633-1645
    • Herranz, H.1    Perez, L.2    Martin, F.A.3    Milan, M.4
  • 87
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000; 19: 5636-5642.
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 88
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009; 139: 693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 89
    • 77955992756 scopus 로고    scopus 로고
    • STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
    • Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol cell 2010; 39: 493-506.
    • (2010) Mol Cell , vol.39 , pp. 493-506
    • Iliopoulos, D.1    Jaeger, S.A.2    Hirsch, H.A.3    Bulyk, M.L.4    Struhl, K.5
  • 90
    • 36749004944 scopus 로고    scopus 로고
    • Mechanisms controlling cell cycle exit upon terminal differentiation
    • Buttitta LA, Edgar BA. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol 2007; 19: 697-704.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 697-704
    • Buttitta, L.A.1    Edgar, B.A.2
  • 91
    • 77950455135 scopus 로고    scopus 로고
    • JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells
    • Liu W, Singh SR, Hou SX. JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. J Cell Biochem 2010; 109: 992-999.
    • (2010) J Cell Biochem , vol.109 , pp. 992-999
    • Liu, W.1    Singh, S.R.2    Hou, S.X.3
  • 92
    • 1642330518 scopus 로고    scopus 로고
    • Notchdependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-toendocycle transition in Drosophila follicle cells
    • Schaeffer V, Althauser C, Shcherbata HR, Deng WM, Ruohola-Baker H. Notchdependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-toendocycle transition in Drosophila follicle cells. Curr Biol 2004; 14: 630-636.
    • (2004) Curr Biol , vol.14 , pp. 630-636
    • Schaeffer, V.1    Althauser, C.2    Shcherbata, H.R.3    Deng, W.M.4    Ruohola-Baker, H.5
  • 93
    • 3042847983 scopus 로고    scopus 로고
    • The mitotic-toendocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions
    • Shcherbata HR, Althauser C, Findley SD, Ruohola-Baker H. The mitotic-toendocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development 2004; 131: 3169-3181.
    • (2004) Development , vol.131 , pp. 3169-3181
    • Shcherbata, H.R.1    Althauser, C.2    Findley, S.D.3    Ruohola-Baker, H.4
  • 94
    • 0032510035 scopus 로고    scopus 로고
    • Continuous cyclin e expression inhibits progression through endoreduplication cycles in Drosophila
    • Weiss A, Herzig A, Jacobs H, Lehner CF. Continuous cyclin E expression inhibits progression through endoreduplication cycles in Drosophila. Curr Biol 1998; 8: 239-242.
    • (1998) Curr Biol , vol.8 , pp. 239-242
    • Weiss, A.1    Herzig, A.2    Jacobs, H.3    Lehner, C.F.4
  • 95
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    • Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Goktuna SI, Ziegler PK et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 2013; 152: 25-38.
    • (2013) Cell , vol.152 , pp. 25-38
    • Schwitalla, S.1    Fingerle, A.A.2    Cammareri, P.3    Nebelsiek, T.4    Goktuna, S.I.5    Ziegler, P.K.6
  • 96
    • 41649093071 scopus 로고    scopus 로고
    • The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    • Bowman SK, Rolland V, Betschinger J, Kinsey KA, Emery G, Knoblich JA. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell 2008; 14: 535-546.
    • (2008) Dev Cell , vol.14 , pp. 535-546
    • Bowman, S.K.1    Rolland, V.2    Betschinger, J.3    Kinsey, K.A.4    Emery, G.5    Knoblich, J.A.6
  • 99
    • 78650187792 scopus 로고    scopus 로고
    • The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    • Shaw RL, Kohlmaier A, Polesello C, Veelken C, Edgar BA, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 2010; 137: 4147-4158.
    • (2010) Development , vol.137 , pp. 4147-4158
    • Shaw, R.L.1    Kohlmaier, A.2    Polesello, C.3    Veelken, C.4    Edgar, B.A.5    Tapon, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.