Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signaling axis

Cellular and Molecular Life Sciences

Volumn 70, Issue 1, 2013, Pages 167-180

  Dalagiorgou, Georgia ^a   Piperi, Christina ^a   Georgopoulou, Urania ^b   Adamopoulos, Christos ^a   Basdra, Efthimia K ^a   Papavassiliou, Athanasios G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HELLENIC PASTEUR INSTITUTE   (Greece)

Author keywords

Calcineurin NFAT pathway; Human osteoblastic cells; Mechanotransduction; Polycystin 1 (PC1); Runx2

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; POLYCYSTIN 1; POLYCYSTIN 2; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR RUNX2;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOMECHANICS; CELL FUNCTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RUNX2 GENE; STRETCHING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CALCINEURIN; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; NFATC TRANSCRIPTION FACTORS; OSTEOBLASTS; OSTEOGENESIS; PHYSICAL STIMULATION; RNA, MESSENGER; TRPP CATION CHANNELS;

EID: 84872324638     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1164-5     Document Type: Article

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