Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch

Journal of Biological Chemistry

Volumn 289, Issue 41, 2014, Pages 28271-28283

  Tang, Wei ^a   Strachan, Ryan T ^a   Lefkowitz, Robert J ^a   Rockman, Howard A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL ACTIVATION; LIGANDS; OSMOSIS; SCAFFOLDS (BIOLOGY);

ALLOSTERIC MODULATION; BINDING AFFINITIES; MECHANICAL STRETCH; MULTIFUNCTIONAL SCAFFOLD; PATHOPHYSIOLOGICAL; RECEPTOR SIGNALING; RECEPTOR-MEDIATED SIGNALING; SIGNALING PATHWAYS;

SIGNALING;

ANGIOTENSIN 1 RECEPTOR; BETA ARRESTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ANGIOTENSIN II; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOPEPTIDE; RETINA S ANTIGEN; SARCOSINE-ARGINYL-VALYL-TYROSYL-LYSYL-HISTIDYL-PROLYL-ALANINE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BIOPHYSICS; BIOSENSOR; CONTROLLED STUDY; ENZYME ACTIVATION; HEK293 CELL LINE; HUMAN; MEMBRANE BIOLOGY; MEMBRANE STRETCH; MOLECULAR MECHANICS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE; AGONISTS; BIOMECHANICS; CELL MEMBRANE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC PROCEDURES; GENETICS; MECHANOTRANSDUCTION; METABOLISM; OSMOTIC PRESSURE;

ALLOSTERIC REGULATION; ANGIOTENSIN II; ARRESTINS; BIOMECHANICAL PHENOMENA; BIOSENSING TECHNIQUES; CELL MEMBRANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; OLIGOPEPTIDES; OSMOTIC PRESSURE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECOMBINANT FUSION PROTEINS;

EID: 84907821993     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.585067     Document Type: Article

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