Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca2+ entry through interactions with STIM1

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Woodward, Owen M ^a   Li, Yun ^a   Yu, Shengqiang ^a,c   Greenwell, Patrick ^a   Wodarczyk, Claas ^b   Boletta, Alessandra ^b   Guggino, William B ^a   Qian, Feng ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DULBECCO TELETHON INSTITUTE   (Italy)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; POLYCYSTIN 1; PROTEIN P100; STROMAL INTERACTION MOLECULE 1; THAPSIGARGIN; CALCIUM; CALCIUM CHANNEL; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; STIM1 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CELLULAR DISTRIBUTION; CHO CELL; CONTROLLED STUDY; EMBRYO; EPITOPE MAPPING; EXTRACELLULAR CALCIUM; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE TRANSLOCATION; IMMUNOPRECIPITATION; KIDNEY POLYCYSTIC DISEASE; MOUSE; NONHUMAN; OOCYTE; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; TISSUE DISTRIBUTION; XENOPUS LAEVIS; ANIMAL; CELL MEMBRANE; CHEMISTRY; CRICETULUS; DOG; ELECTRIC CONDUCTIVITY; ENDOPLASMIC RETICULUM; HAMSTER; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TRANSPORT;

MUS; XENOPUS LAEVIS;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; ELECTRIC CONDUCTIVITY; ENDOPLASMIC RETICULUM; HUMANS; MEMBRANE PROTEINS; MICE; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN TRANSPORT; TRPP CATION CHANNELS;

EID: 77957882874     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012305     Document Type: Article

References (40)

1. Wilson PD (2004) Polycystic kidney disease. N Engl J Med 350: 151-164.
2. Sutters M, Germino GG (2003) Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med 141: 91-101.
3. Kottgen M (2007) TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta 1772: 836-850.
4. Somlo S, Ehrlich B (2001) Human disease: calcium signaling in polycystic kidney disease. Curr Biol 11: R356-R360.
5. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33: 129-137.
6. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, et al. (2000) Coassembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408: 990-994.
7. 2+ concentration in the endoplasmic reticulum. EMBO J 28: 490-499.
8. 2+ signaling. J Biol Chem 280: 41298-41306.
9. Simons M, Walz G (2006) Polycystic kidney disease: cell division without a c(l)ue? Kidney Int 70: 854-864.
10. Orrenius S, Zhivotovsky B, Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4: 552-565.
11. Hooper KM, Boletta A, Germino GG, Hu Q, Ziegelstein RC, et al. (2005) Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells. Am J Physiol Renal Physiol 289: F521-F530.
12. Hogan PG, Rao A (2007) Dissecting ICRAC, a store-operated calcium current. Trends Biochem Sci 32: 235-245.
13. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, et al. (2006) Orai1 is an essential pore subunit of the CRAC channel. Nature 443: 230-233.
14. Wei W, Hackmann K, Xu H, Germino G, Qian F (2007) Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene. J Biol Chem 282: 21729-21737.
15. Qian F, Boletta A, Bhunia AK, Xu H, Liu L, et al. (2002) Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A 99: 16981-16986.
16. Yu S, Hackmann K, Gao J, He X, Piontek K, et al. (2007) Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A 104: 18688-18693.
17. Chauvet V, Tian X, Husson H, Grimm DH, Wang T, et al. (2004) Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest 114: 1433-1443.
18. Lal M, Song X, Pluznick JL, Di G, V, Merrick DM, et al. (2008) Polycystin-1 Cterminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet 17: 3105-3117.
19. Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, et al. (2003) Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. J Biol Chem 278: 36786-36793.
20. 2+ signaling with implications for polycystic kidney disease. J Biol Chem 284: 36431-36441.
21. Wodarczyk C, Rowe I, Chiaravalli M, Pema M, Qian F, et al. (2009) A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4: e7137.
22. Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B, et al. (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272: 1339-1342.
23. Barish ME (1983) A transient calcium-dependent chloride current in the immature Xenopus oocyte. J Physiol 342: 309-325.
24. Hartzell HC (1996) Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx. J Gen Physiol 108: 157-175.
25. Yao Y, Tsien RY (1997) Calcium current activated by depletion of calcium stores in Xenopus oocytes. J Gen Physiol 109: 703-715.
26. Bertuccio CA, Chapin HC, Cai Y, Mistry K, Chauvet V, et al. (2009) Polycystin- 1 C-terminal cleavage is modulated by polycystin-2 expression. J Biol Chem 284: 21011-21026.
27. Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS (2008) Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 454: 538-542.
28. 2+ channels that lead to normal epithelial cell apoptosis. Mol Biol Cell 19: 2220-2230.
29. Li N, Zheng L, Lin P, Danielpour D, Pan Z, et al. (2008) Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. J Cell Physiol 216: 172-179.
30. Vanden AF, Skryma R, Shuba Y, Van CF, Slomianny C, et al. (2002) Bcl-2- dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells. Cancer Cell 1: 169-179.
31. 2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cells. Cell Death Differ 11: 321-330.
32. 2+ entry. Am J Physiol Renal Physiol 285: F1168-F1178.
33. Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, et al. (2005) The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s). Exp Cell Res 304: 391-406.
34. Basavanna U, Weber KM, Hu Q, Ziegelstein RC, Germino GG, et al. (2007) The isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling. Biochem Biophys Res Commun 359: 367-372.
35. 2+ store depletion. Proc Natl Acad Sci U S A 104: 9301-9306.
36. Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M (2008) Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell 135: 110-122.
37. Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, et al. (2009) STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell 136: 876-890.
38. 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A 103: 16704-16709.
39. 2+ channel activation. J Biol Chem 282: 29448-29456.
40. Smyth JT, Petranka JG, Boyles RR, DeHaven WI, Fukushima M, et al. (2009) Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol 11: 1465-1472.