Carbon nanotubes exposure risk assessment: From toxicology to epidemiologic studies (Overview of the current problem)

Nanotechnologies in Russia

Volumn 10, Issue 5-6, 2015, Pages 501-509

  Fatkhutdinova, L M ^a   Khaliullin, T O ^a   Shvedova, A A ^b  

^a KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; HEALTH RISKS; INDUSTRIAL RESEARCH; RISK ASSESSMENT; YARN;

CURRENT PROBLEMS; EPIDEMIOLOGIC-STUDY; EPIDEMIOLOGICAL STUDIES; EXPOSURE ASSESSMENT; HIGH REACTIVITY; MATERIAL SAFETY; NANOSCALE SIZE; TOXICOLOGICAL EVALUATION;

CARBON NANOTUBES;

EID: 84935873135     PISSN: 19950780     EISSN: 19950799     Source Type: Journal    
DOI: 10.1134/S1995078015030064     Document Type: Article

References (97)

1. Commission Recommendation of 18 October 2011 on the definition of nanomaterial (Text with EEA relevance). http://eur-lex.europa.eu/LexUriServ/Lex-UriServ.do?uri=CELEX:32011H0696:EN:NOT (Assessed 19.11.14).
2. GN (Hygienic Norms) no. 1.2.2633-10. Hygienic Norms for Priority Nanomaterials Content in the Environmental Objects (2010.05.25).
3. A. A. Gusev, I. A. Polyakova, E. B. Gorsheneva, et al., “Gender difference of physiological effect of carbon nanostructured material which is a promising medicine carrier in laboratory mice experiment,” Nauch. Vedomosti Belgorod. Gos. Univ. Ser.: Estestv. Nauki, No. 13, 107–112 (2010).
4. Global Markets and Technologies for Carbon Nanotubes. http://www.bccresearch.com/report/carbon-nantubes-markets-technologies-nan024e.html (Assessed 19.11.14).
5. Future Needs and Opportunities in Nanotechnology for Aerospace Applications—A NASA Perspective. http://inc10.org/talks/meador_slides.pdf (Assessed 19.11.14).
6. MR (Methodological Recommendations) no. 1.2.0037-11: Check-up Procedure for Nanomaterials in the Air (17.10.2011).
7. MR (Methodological Recommendations) no. 1.2.2639-10: The Way to Use Quantitative Methods for Determining Nanomaterials in Nanoindustry (24.05.2010).
8. Maximal Permissible Concentrations (MPC) for Dangerous Matters in the Air of Working Zone: Hygienic Norms (Russian Register of Potentially Dangerous Chemical and Biological Substances, Moscow, 2003) [in Russian].
9. Prediction of Russian Federation Scientific-Technical Development till 2030 (Approved by Russian Government, 3.01.2014) [in Russian].
10. T. O. Khaliullin, E. R. Kisin, R. R. Zalyalov, et al., “Biological effects of multiwalled carbon nanotubes under in vivo pulmonary exposure,” Toksikol. Vestn., No. 4, 17–21 (2013).
11. T. O. Khaliullin, E. R. Kisin, R. E. Murray, et al., “Toxic effects of carbon nanotubes in macrophage and bronchial epithelium cell cultures,” Vestn. Tomsk. Gos. Univ. Biol., No. 1, 199–210 (2014).
12. T. O. Khaliullin, A. A. Shvedova, E. R. Kisin, et al., “Evaluation of fibrogenic potential of industrial multiwalled carbon nanotubes in acute aspiration experiment,” Bull. Exp. Biol. Med. 158(5), 684–687 (2015).
13. K. Aschberger, H. Johnston, V. Stone, et al., “Review of carbon nanotubes toxicity and exposure—appraisal of human health risk assessment based on open literature,” Crit. Rev. Toxicol. 40(9), 759–790 (2010).
14. P. A. Baron, A. D. Maynard, and M. Foley, “Evaluation of aerosol release during the handling of unrefined single walled carbon nanotubes material,” NIOSH Report No. NIOSH DART-02-191 (2002).
15. N. Behabtu, C. C. Young, D. E. Tsentalovich, et al., “Strong, light, multifunctional fibers of carbon nanotubes with ultrahigh conductivity,” Science 339(6116), 182–186 (2013).
16. S. Breitner, M. Stölzel, J. Cyrys, et al., “Short-term mortality rates during a decade of improved air quality in Erfurt, Germany,” Environ. Health Perspect. 117(3), 448–454 (2009).
17. H. G. Chae, Y. H. Choi, M. L. Minus, et al., “Carbon nanotube reinforced small diameterpolyacrylonitrile based carbon fiber,” Compos. Sci. Technol. 69, 406 (2009).
18. M. M. Dahm, D. E. Evans, M. K. Schubauer-Berigan, et al., “Occupational exposure assessment in carbon nanotube and nanofiber primary and secondary manufacturers: mobile direct-reading sampling,” Ann. Occup. Hyg. 57(3), 328–344 (2013).
19. L. Dai, D. W. Chang, J.-B. Baek, and W. Lu, “Carbon nanomaterials for advanced energy conversion and storage,” Small 8, 1130–1166 (2012).
20. M. Davoren, E. Herzog, and A. Casey, “In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells,” Toxicol. in vitro, No. 21(3), 438–448 (2007).
21. R. de Winter-Sorkina and F. R. Cassee, “Multiple path particle dosimetry model (MPPD v1.0): a model for human and rat airway particle dosimetry,” National Institute for Public Health and the Environment (RIVM) Report (Bilthoven, 2002).
22. D. W. Dockery, C. A. Pope, X. Xu, et al., “An association between air pollution and mortality in six U.S. cities,” N. Engl. J. Med. 329(24), 1753–1759 (1993).
23. K. Donaldson, R. Aitken, L. Tran, et al., “Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety,” Toxicol. Sci. 92(1), 5–22 (2006).
24. K. Donaldson, V. Stone, A. Seaton, et al., “Re: induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube,” J. Toxicol. Sci. 33(3), 385 (2008).
25. A. Erdely, T. Hulderman, R. Salmen, et al., “Crosstalk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers,” Nano Lett. 9(1), 36–43 (2009).
26. A. Erdely, M. Dahm, B. T. Chen, et al., “Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology,” Part. Fibre Toxicol. 10, 53 (2013).
27. Exposure Assessment and Epidemiological Study of U.S. Workers Exposed to Carbon Nanotubes and Carbon Nanofibers. http://www.gpo.gov/fdsys/pkg/FR-2012-09-20/pdf/2012-23194.pdf
28. T. Fujitani, K. Ohyama, A. Hirose, et al., “Teratogenicity of Multi-Wall Carbon Nanotube (MWCNT) in ICR mice,” J. Toxicol. Sci. 37(1), 81–89 (2012).
29. M. Ghosh, A. Chakraborty, M. Bandyopadhyay, and A. Mukherjee, “Multi-Walled Carbon Nanotubes (MWCNT): induction of DNA damage in plant and mammalian cells,” J. Hazard. Mater. 197, 327–336 (2011).
30. H. Greim, P. Borm, R. Schins, et al., “Toxicity of fibers and particles. Report of the Workshop held in Munich, Germany, 26–27 October (2000),” Inhal. Toxicol. 13(9), 737–754 (2001).
31. Y. Grosse, D. Loomis, K. Z. Guyton, et al., “Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes,” Lancet Oncol. 15(13), 1427 (2014).
32. H. Grubek-Jaworska, P. Nejman, K. Czuminska, et al., “Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons,” Carbon 44, 1057–1063 (2006).
33. S. G. Han, Y. Kim, M. L. Kashon, et al., “Correlates of oxidative stress and free-radical activity in serum from asymptomatic shipyard welders,” Am. J. Respir. Crit. Care Med. 172, 1541–1548 (2005).
34. X. He, S. H. Young, D. Schwegler-Berry, et al., “Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, Activating NF-êB signaling, and promoting fibroblastto-myofibroblast transformation,” Chem. Res. Toxicol. 24(12), 2237–2248 (2011).
35. R. Herbert, J. Moline, G. Skloot, et al., “The world trade center disaster and the health of workers: five-year assessment of a unique medical screening program,” Environ. Health Perspect. 114(12), 1853–1858 (2006).
36. S. Hirano, Y. Fujitani, A. Furuyama, and S. Kanno, “Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells,” Toxicol. Appl. Pharmacol. 249(1), 8–15 (2010).
37. S. Hirano, S. Kanno, and A. Furuyama, “Multi-walled carbon nanotubes injure the plasma membrane of macrophages,” Toxicol. Appl. Pharmacol. 232(2), 244–251 (2008).
38. M. Ilves, E. Rydman, K. Savolainen, and H. Alenius, “Rigid rod-like carbon nanotubes induce signs of allergic asthma, in Proc. 2nd Int. School Conf. ANNT-2013, Ed. by A. Vedyagin (Listvyanka, Irkutsk Region, Aug. 15–19, 2013).
39. S. Ivani, I. Karimi, and S. R. Tabatabaei, “Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach,” Sci. Toxicol. 37(6), 1191–1205 (2012).
40. G. Joseph, “Industrial hygiene air monitoring report,” DuPont Co. Internal Report (Oct. 2002).
41. T. Kato, Y. Totsuka, K. Ishino, et al., “Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems,” Nanotoxicology 7(4), 452–461 (2013).
42. J. S. Kim, K. S. Song, J. K. Lee, et al., “Toxicogenomic comparison of Multi-Wall Carbon Nanotubes (MWCNTs) and asbestos,” Arch. Toxicol. 86, 553–562 (2012).
43. T. Kondo, N. Hattori, N. Ishikawa, et al., “KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome,” Respir. Res. 22, 12–32 (2011).
44. C. W. Lam, J. T. James, R. McCluskey, and R. L. Hunter, “Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation,” Toxicol. Sci. 77(1), 126–134 (2004).
45. S. H. Liou, M. H. Lin, C. H. Hsu, et al., “Pilot study of health hazards among engineered nanoparticles manufacturing workers,” J. Occupat. Environ. Med. 60,Suppl. 1, Art. A100 (2010).
46. L. Ma-Hock, S. Treumann, V. Strauss, et al., “Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months,” Toxicol. Sci. 112(2), 468–481 (2009).
47. J. B. Mangum, E. A. Turpin, A. Antao-Menezes, et al., “Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF MRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ,” Part. Fibre Toxicol. 3, 15 (2006).
48. A. D. Maynard, P. A. Baron, M. Foley, et al., “Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material,” J. Toxicol. Environ. Health A 67, 87–107 (2004).
49. R. R. Mercer, A. F. Hubbs, J. F. Scabilloni, et al., “Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes,” Part. Fiber Toxicol. 8, 21 (2011).
50. R. R. Mercer, J. Scabilloni, L. Wang, et al., “Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model,” Am. J. Physiol. Lung Cell Mol. Physiol. 294(1), 87–97 (2008).
51. R. R. Mercer, J. F. Scabilloni, A. F. Hubbs, et al., “Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes,” Part Fibre Toxicol. 10, 33 (2013).
52. M. Methner, L. Hodson, and C. Geraci, “Nanoparticle Emission Assessment Technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials. Part A,” J. Occup. Environ. Hyg. 7(3), 127–132 (2010).
53. L. Migliore, D. Saracino, A. Bonelli, et al., “Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells,” Environ. Mol. Mutagen., No. 51(4), 294–303 (2010).
54. L. A. Mitchell, F. T. Lauer, S. W. Burchiel, and J. D. McDonald, “Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice,” Nat. Nanotechnol. 4(7), 451–456 (2009).
55. N. A. Monteiro-Riviere, R. J. Nemanich, A. O. Inman, et al., “Multi-walled carbon nanotube interactions with human epidermal keratinocytes,” Toxicol. Lett. 155(3), 377–384 (2005).
56. Y. Morimoto, M. Horie, N. Kobayashi, et al., “Inhalation toxicity assessment of carbon-based nanoparticles,” Acc. Chem. Res. 46(3), 770–781 (2013).
57. J. Muller, F. Huaux, N. Moreau, et al., “Respiratory toxicity of multi-wall carbon nanotubes,” Toxicol. Appl. Pharmacol. 207(3), 221–231 (2005).
58. J. Nakanishi, “Risk assessment of manufactured nanomaterials: Carbon Nanotubes (CNTs),” NEDO project (P06041) Research and Development of Nanoparticle Characterization Methods (2011).
59. J. Nakanishi, “Risk assessment of manufactured nanomaterials: “approaches”—overview of approaches and results,” NEDO project. (P06041) Research and Development of Nanoparticle Characterization Methods (2011).
60. F. Luizi, “Nanocyl. Responsible care and nanomaterials case study Nanocyl,” in Proc. European Responsible Care Conf. (Prague, Oct. 21–23, 2009). http://www.cefic.org/Documents/ResponsibleCare/04_Nanocyl.pdf
61. A. Nel, T. Xia, L. Madler, and N. Li, “Toxic potential of materials at the nanolevel,” Science 311(5761), 622–627 (2006).
62. NIOSH Current intelligence bulletin. Occupational Exposure to Carbon Nanotubes and Nanofibers. http://www.cdc.gov/niosh/docket/review/docket161a/pdfs/carbonNanotubeCIB_PublicReviewOfDraft.pdf
63. NIOSH Current Intelligence Bulletin No. 65. Occupational Exposure to Carbon Nanotubes and Nanofibers. http://www.cdc.gov/niosh/docs/2013-145/pdfs/2013-145.pdf
64. U. C. Nygaard, J. S. Hansen, M. Samuelsen, et al., “Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice,” Toxicol. Sci. 109(1), 113–123 (2009).
65. B. Ouyang, C. S. Baxter, H. M. Lam, et al., “Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene,” J. Occup. Environ. Med. 54(7), 774–780 (2012).
66. J. Palomäki, E. Välimäi, J. Sund, et al., “Long, Nneedle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism,” ACS Nano 5(9), 6861–6870 (2011).
67. J. Pauluhn, “Multi-walled carbon nanotubes (baytubes): approach for derivation of occupational exposure limit,” Regul. Toxicol. Pharmacol. 57(1), 78–89 (2010).
68. C. A. Poland, R. Duffin, and I. Kinloch, “Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study,” Nat. Nanotechnol. 3(7), 423–428 (2008).
69. C. A. Pope III, M. Ezzati, and D. W. Dockery, “Fineparticulate air pollution and life expectancy in the United States,” N. Engl. J. Med. 360(4), 376–386 (2009).
70. D. W. Porter, A. F. Hubbs, R. R. Mercer, et al., “Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes,” Toxicology 269(2–3), 136–147 (2010).
71. A. E. Porter, M. Gass, K. Muller, et al., “Direct imaging of single-walled carbon nanotubes in cells,” Nat. Nanotechnol. 2, 713–717 (2007).
72. C. Powers, J. Gift, and G. Lehmann, “Sparking connections: toward better linkages between research and human health policy — an example with multiwalled carbon nanotubes,” Toxicol. Sci. 141(1), 6–17 (2014).
73. Reference Methods for Measuring Airborne Man-Made Mineral Fibers (World Health Organization, Copenhagen, 1985).
74. J. P. Ryman-Rasmussen, M. F. Cesta, A. R. Brody, et al., “Inhaled carbon nanotubes reach the subpleural tissue in mice,” Nat. Nanotechnol. 4(11), 747–751 (2009).
75. N. Saito, H. Haniu, Yu. Usui, et al., “Safe clinical use of carbon nanotubes as innovative biomaterials,” Chem. Rev. 114(11), 6040–6079 (2014).
76. L. M. Sargent, S. H. Reynolds, and V. Castranova, “Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects,” Nanotoxicology, 396–408 (2010).
77. L. M. Sargent, D. W. Porter, L. M. Staska, et al., “Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotube,” Part. Fibre Toxicol. 11, 3 (2014).
78. S. C. Sharma, S. Sarkar, A. Periyakaruppan, et al., “Single-walled carbon nanotube induces oxidative stress in rat lung epoithelial cells,” J. Nanosci. Nanotechnol. 7(7), 2466–2472 (2007).
79. K. N. Shields, J. M. Cavallari, M. J. Hun, et al., “Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: a panel study,” Environ. Health 12, 7 (2013).
80. K. Shimizu, A. Uchiyama, M. Yamashita, et al., “Biomembrane damage caused by exposure to multiwalled carbon nanotubes,” J. Toxicol. Sci. 38(1), 7–12 (2013).
81. A. A. Shvedova, E. Kisin, A. R. Murray, et al., “Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis,” Am. J. Physiol. Lung Cell Mol. Physiol. 295(4), 552–565 (2008).
82. A. A. Shvedova, A. V. Tkach, E. R. Kisin, et al., “Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells,” Small, Nos. 9–10, 1691–1695 (2013).
83. A. A. Shvedova, V. Castranova, E. R. Kisin, et al., “Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells,” J. Toxicol. Environ. Health A 66(20), 1909–1926 (2003).
84. A. A. Shvedova, E. R. Kisin, R. Mercer, et al., “Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice,” Am. J. Physiol. Lung Cell. Mol. Physiol., No. 289, 698–708 (2005).
85. A. A. Shvedova, N. Yanamala, E. R. Kisin, et al., “Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons,” Am. J. Physiol. Lung Cell Mol. Physiol. 306(2), 170–182 (2014).
86. R. K. Srivastava, A. B. Pant, M. P. Kashyap, et al., “Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549,” Nanotoxicology 5(2), 195–207 (2011).
87. M. Stölzel, S. Breitner, J. Cyrys, et al., “Daily mortality and particulate matter in different size classes in Erfurt, Germany,” J. Expo Sci. Environ. Epidemiol. 17(5), 458–467 (2007).
88. A. Takagi, A. Hirose, T. Nishimura, et al., “Induction of mesothelioma in P53+/- mouse by intraperitoneal application of multi-wall carbon nanotube,” J. Toxicol. Sci. 33(1), 105–116 (2008).
89. T. Takahashi, M. Munakata, I. Suzuki, and Y. Kawakami, “Serum and bronchoalveolar fluid KL-6 levels in patients with pulmonary alveolar proteinosis,” Am. J. Respir. Crit. Care Med. 158(4), 1294–1298 (1998).
90. D. Theegarten, S. Boukercha, S. Philippou, and O. Anhenn, “Submesothelial deposition of carbon nanoparticles after toner exposition: case report,” Diagn. Pathol. 5, 77 (2010).
91. H. Tong, J. K. McGee, R. K. Saxena, et al., “Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice,” Toxicol. Appl. Pharmacol. 239(3), 224–232 (2009).
92. R. Vermeulen, A. Pronk, J. Vlaanderen, et al., “0282 a cross-sectional study of markers of early immunological and cardiovascular health effects among a population exposed to carbon nanotubes: the CANTES study,” Occup. Environ. Med. 71, Suppl. A, A35 (2014).
93. W. Wang, Y. Zhu, S. Liao, and J. Li, “Carbon nanotubes reinforced composites for biomedical applications,” BioMed Res. Int. 2014, 1–14 (2014).
94. D. B. Warheit, B. R. Laurence, K. L. Reed, et al., “Comparative pulmonary toxicity assessment of singlewall carbon nanotubes in rats,” Toxicol. Sci. 77, 117–125 (2004).
95. H. E. Wichmann, C. Spix, T. Tuch, et al., “Daily mortality and fine and ultrafine particles in Erfurt, Germany. Part I: role of particle number and particle mass,” Res. Rep. Health Eff. Inst. 98, 5–86 (2000).
96. M. Wu, R. E. Gordon, R. Herbert, et al., “Case report: lung disease in world trade center responders exposed to dust and smoke: carbon nanotubes found in the lungs of world trade center patients and dust samples,” Environ. Health Perspect. 118(4), 499–504 (2010).
97. G. Yakovlev, G. Pervushin, I. Maeva, et al., “Modification of construction materials with multi-walled carbon nanotubes,” Proc. Eng. 57, 407–413 (2013).