KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome

Respiratory Research

Volumn 12, Issue 1, 2011, Pages

  Kondo, Tomohiro ^a   Hattori, Noboru ^a   Ishikawa, Nobuhisa ^a   Murai, Hiroshi ^a   Haruta, Yoshinori ^a   Hirohashi, Nobuyuki ^b   Tanigawa, Koichi ^b   Kohno, Nobuoki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; KL 6 PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; MUC1 PROTEIN, HUMAN; MUCIN 1;

ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; ARTIFICIAL VENTILATION; BRONCHOSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL LINING FLUID; FEMALE; HUMAN; INTUBATION; MALE; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; ANALYSIS OF VARIANCE; BLOOD; IMMUNOLOGY; JAPAN; KAPLAN MEIER METHOD; LUNG LAVAGE; METABOLISM; MIDDLE AGED; MORTALITY; PREDICTIVE VALUE; RESPIRATORY TRACT MUCOSA; SURVIVAL RATE; TIME; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; FEMALE; HUMANS; JAPAN; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MUCIN-1; PREDICTIVE VALUE OF TESTS; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MUCOSA; ROC CURVE; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 79953068067     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-32     Document Type: Article

References (29)

1. Pugin J, Verghese G, Widmer MC, Matthay MA: The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 1999, 27:304-312.
2. Ware LB, Matthay MA: Medical progress: the acute respiratory distress syndrome. N Engl J Med 2000, 342:1334-1349.
3. Brigham KL: Lung edema due to increased vascular permeability. In Lung Water and Solute Exchange. Edited by: Staub NC. New York: Dekker; 1978:235-276.
4. Matthay MA, Wiener-Kronish JP: Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990, 142:1250-1257.
5. Pittet JF, Mackersie RC, Martin TR, Matthay MA: Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med 1997, 155:1187-1205.
6. Wiener-Kronish JP, Albertine KH, Matthay MA: Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 1991, 88:864-875.
7. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA: Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med 1999, 160:1450-1456.
8. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB, Hull W, Whitsett JA, Akino T, Kuroki Y, Nagae H, Hudso LD, Martin TR: Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med 1999, 160:1843-1850.
9. Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP: Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest 1999, 104:743-750.
10. Bitterman PB: Pathogenesis of fibrosis in acute lung injury. Am J Med 1992, 92:39S-43S.
11. Stahel RA, Gilks WR, Lehmann HP, Schenker T: Third international workshop on lung tumor and differentiation antigens: overview of the results of the central data analysis. Int J CancerSuppl 1994, 8:6-26.
12. Kohno N, Kyoizumi S, Awaya Y, Fukuhara H, Yamakido M, Akiyama M: New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest 1989, 96:68-73.
13. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S: Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2004, 286:L1088-L1094.
14. Kohno N, Awaya Y, Oyama T, Yamakido M, Akiyama M, Inoue Y, Yokoyama A, Hamada H, Fujioka S, Hiwada K: KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Am Rev Respir Dis 1993, 148:637-642.
15. Oyama T, Kohno N, Yokoyama A, Hirasawa Y, Hiwada K, Oyama H, Okuda Y, Takasugi K: Detection of interstitial pneumonitis in patients with rheumatoid arthritis by measuring circulating levels of KL-6, a human MUC1 mucin. Lung 1997,175(6):379-385.
16. Kohno N, Yokoyama A, Hirasawa Y, Kondo K, Fujino S, Abe M, Hiwada K: Comparative studies of circulating KL-6, type III procollagen N-terminal peptide and type IV collagen 7 S in patients with interstitial pneumonitis and alveolar pneumonia. Respir Med 1997,91(9):558-561.
17. Hamada H, Kohno N, Yokoyama A, Hirasawa Y, Hiwada K, Sakatani M, Ueda E: KL-6 as a serologic indicator of Pneumocystis carinii pneumonia in immunocompromised hosts. Intern Med 1998,37(3):307-310.
18. Yokoyama A, Kohno N, Kondo K, Ueda S, Hirasawa Y, Watanabe K, Takada Y, Hiwada K: Comparative evaluation of sialylated carbohydrate antigens, KL-6, CA19-9 and SLX as serum markers for interstitial pneumonia. Respirology 1998,3(3):199-202.
19. Kohno N: Serum marker KL-6/MUC1 for the diagnosis and management of interstitial pneumonitis. J Med Invest 1999,46(3-4):151-158.
20. Ohnishi H, Yokoyama A, Kondo K, Hamada H, Abe M, Nishimura K, Hiwada K, Kohno N: Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung disease. Am J Respir Crit Care Med 2002,165(3):378-381.
21. Inoue Y, Barker E, Daniloff E, Kohno N, Hiwada K, Newman LS: Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. Am J Respir Crit Care Med 1997, 156:109-115.
22. Sato H, Callister ME, Mumby S, Quinlan GJ, Welsh KI, duBios RM, Evans TW: KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome. Eur Respir J 2004, 23:142-145.
23. Nathani N, Perkins GD, Tunnicliffe W, Murphy N, Manji M, Thickett DR: Krebs von Lungen 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome. Crit Care 2008,12(1):R12.
24. Ishizaka A, Watanabe M, Yamashita T, Ogawa Y, Koh H, Hasegawa N, Nakamura H, Asano K, Yamaguchi K, Kotani M, Kotani T, Morisaki H, Takeda J, Kobayashi K, Ogawa S: New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. Crit Care Med 2001,29(4):896-898.
25. Ohshimo S, Yokoyama A, Hattori N, Ishikawa N, Hirasawa Y, Kohno N: KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts. Biochem Biophys Res Commun 2005,338(4):1845-1852.
26. Ware LB, Matthay MA: Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001,163(6):1376-1383.
27. Kawanami O, Ferrans VJ, Crystal RG: Structure of alveolar epithelial cells in patients with fibrotic lung disorders. Lab Invest 1982,46(1):39-53.
28. Fukuda Y, Ferrans VJ, Schoenberger CI, Rennard SI, Crystal RG: Patterns of pulmonary structural remodeling after experimental paraquat toxicity. The morphogenesis of intraalveolar fibrosis. Am J Pathol 1985,118(3):452-475.
29. Briassoulis G, Mavrikiou M, Margeli A, Lazaropoulou C, Natsi L, Papassotiriou I, Hatzis T: Circulating levels of KL-6 in acute respiratory distress syndrome sepsis or traumatic brain injury in critically ill children. Pediatr Pulmonol 2006,41(8):790-795.